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YILMAZ, BETÜL

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YILMAZ

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BETÜL

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2011 - 201912020 - 20211
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    Cellular Protection and Therapeutic Potential of Tocotrienols
    (BENTHAM SCIENCE PUBL LTD, 2011) YILMAZ, BETÜL; Catalgol, Betul; Batirel, Saime; Ozer, Nesrin Kartal
    Tocotrienols, components belonging to vitamin E members, are used as potent therapeutics in the treatment of several diseases. Recent studies suggested tocotrienol to have better activity in many situations compared to tocopherols. Tocotrienols have been shown to lower the atherogenic apolipoprotein B and lipoprotein plasma levels. Additionally, tocotrienols with their anti-tumor effect together with anti-angiogenic and anti-thrombotic effects may serve as effective agents in cancer therapy. Besides these effects, some properties such as water insolubility and low stability limit the usage of tocotrienols in the clinic. However recent studies tried to increase the bioavailability with esterification and combination use. These efforts for the clinical usage of tocotrienols which may help them to take a wide place in the clinic and additional studies are needed to identify their therapeutical mechanisms.
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    The Repertoire of Glycan Alterations and Glycoproteins in Human Cancers
    (MARY ANN LIEBERT, INC, 2021) TURANLI, BESTE; Kori, Medi; Aydin, Busra; Gulfidan, Gizem; Beklen, Hande; Kelesoglu, Nurdan; Caliskan Iscan, Aysegul; Turanli, Beste; Erzik, Can; Karademir, Betul; Arga, Kazim Yalcin
    Cancer as the leading cause of death worldwide has many issues that still need to be addressed. Since the alterations on the glycan compositions or/and structures (i.e., glycosylation, sialylation, and fucosylation) are common features of tumorigenesis, glycomics becomes an emerging field examining the structure and function of glycans. In the past, cancer studies heavily relied on genomics and transcriptomics with relatively little exploration of the glycan alterations and glycoprotein biomarkers among individuals and populations. Since glycosylation of proteins increases their structural complexity by several orders of magnitude, glycome studies resulted in highly dynamic biomarkers that can be evaluated for cancer diagnosis, prognosis, and therapy. Glycome not only integrates our genetic background with past and present environmental factors but also offers a promise of more efficient patient stratification compared with genetic variations. Therefore, studying glycans holds great potential for better diagnostic markers as well as developing more efficient treatment strategies in human cancers. While recent developments in glycomics and associated technologies now offer new possibilities to achieve a high-throughput profiling of glycan diversity, we aim to give an overview of the current status of glycan research and the potential applications of the glycans in the scope of the personalized medicine strategies for cancer.