Person: AKDENİZ DOĞAN, ZEYNEP DENİZ
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AKDENİZ DOĞAN
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ZEYNEP DENİZ
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Publication Metadata only Elde skuamöz hücreli karsinom ile birlikte aksiller lenf nodlarında foliküler lenfoma(2010-09-19) AKDENİZ DOĞAN, ZEYNEP DENİZ; DURMUŞ KOCAASLAN, FATMA NİHAL; BAYRAMİÇLİ, MEHMET NURİ ÜMİT; AKDENİZ DOĞAN Z. D., DURMUŞ KOCAASLAN F. N., ERSOY B., DEMİRKESEN C., BAYRAMİÇLİ M. N. Ü.Publication Metadata only Geç dönemde başvuran elde yüksek basınçlı çimento enjeksiyonu ile yaralanma olgusu(2010-09-15) AKDENİZ DOĞAN, ZEYNEP DENİZ; BAYRAMİÇLİ, MEHMET NURİ ÜMİT; AKDENİZ DOĞAN Z. D., ERSOY B., ŞİRİNOĞLU H., BAYRAMİÇLİ M. N. Ü.Publication Metadata only The role of botulinum toxin a injection on neuromuscular end plate reinnervation during peripheral nerve regeneration(2013-05-22) AKDENİZ DOĞAN, ZEYNEP DENİZ; ÖZKAN YENAL, NAZİYE; ERCAN, FERİHA; BAYRAMİÇLİ, MEHMET NURİ ÜMİT; AKDENİZ DOĞAN Z. D., ATEŞ F., ÖZKAN YENAL N., ERCAN F., BAYRAMİÇLİ M. N. Ü.Publication Metadata only The role of botulinum toxin type a-induced motor endplates after peripheral nerve repair(WILEY, 2015) ERCAN, FERİHA; Akdeniz, Zeynep D.; Bayramicli, Mehmet; Ates, Filiz; Oezkan, Naziye; Yucesoy, Can A.; Ercan, FerihaIntroduction: The aim of this study was to test the hypothesis that the increased number of new motor endplates induced by botulinum toxin type A (BTX-A) injection before nerve injury would be reinnervated after nerve repair, resulting in greater force generation. Methods: Thirty male Wistar rats were divided randomly into 3 groups: (1) controls; (2) a group with saline solution injection; and (3) a group with BTX-A injection into gastrocnemius muscle (BTX group). Thirty-six days after the injections the left sciatic nerve was divided and coapted in all groups. Eight weeks later, muscle forces were measured, and histological samples were collected. Results: No differences in the number of innervated endplates were found between the groups, but the number of denervated endplates was higher in the BTX group, as was the muscle tissue degeneration score. The BTX group showed distal muscle force measurements of up to 25.8% less compared with the control group. Conclusion: Although BTX-A injection increases the number of motor endplates, they are not functional. Muscle Nerve 52:412-418, 2015Publication Open Access Symmetrization in breast reconstruction: Augmentation procedures(Springer, London/Berlin , 2021-08-01) AKDENİZ DOĞAN, ZEYNEP DENİZ; BAYRAMİÇLİ, MEHMET NURİ ÜMİT; Bayramiçli M. N. Ü., Akdeniz Doğan Z. D.Publication Metadata only Comparing Venous Thrombosis Rates in Hand-Sewn Anastomosis to Anastomotic Coupler Devices(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2021) SAÇAK, BÜLENT; Dogan, Zeynep Akdeniz; Aydin, Cem; Cavus-Ozkan, Melekber; Sacak, Bulent; Bayramicli, MehmetBackground: Anastomotic coupling device (ACD) has reached wide popularity, especially in venous anastomosis of free-tissue transfers. There are scant reviews in the literature about the reliability of these devices in venous anastomosis. We retrospectively analyzed our free flap cases to compare the thrombosis rates between ACDs and handsewn anastomosis and other possible risk factors that may contribute to venous thrombosis. Materials and Methods: Data of all microvascular free-tissue transfers performed between January 2015 and August 2019 were retrospectively reviewed. Patient characteristics were recorded. Reconstruction characteristics such as venous anastomosis type (hand-sewn vs. anastomotic coupler device), reconstruction site, and number of surgical interventions were also recorded. Results: A total of 385 consecutive-free microvascular reconstructions were identified. Total venous thrombosis rate was 4.7%. There was no statistically significant difference between hand-sewn anastomosis and anastomosis with coupler device (5.2% vs. 3.2%, P = 0.58). Only reconstruction site was found to be significantly associated with higher venous thrombosis (P = 0.03). Discussion: Our results involving different reconstruction sites and including multiple flap types demonstrated comparable revision rates between ACDs and hand-sewn anastomosis. This finding is consistent with the current literature.Publication Metadata only Siyalore tedavisinde cerrahi yaklaşım(2009-05-29) AKDENİZ DOĞAN, ZEYNEP DENİZ; BAYRAMİÇLİ, MEHMET NURİ ÜMİT; ŞİRİNOĞLU H., AKDENİZ DOĞAN Z. D., SÖNMEZ A., BAYRAMİÇLİ M. N. Ü.Publication Metadata only Kaşı ve burun dorsumunu içine alan göz kapaklarının bölünmüş dev konjenital nevüsünde cerrahi tedavi(2010-09-19) BAYRAMİÇLİ, MEHMET NURİ ÜMİT; AKDENİZ DOĞAN, ZEYNEP DENİZ; ERSOY B., ŞİRİNOĞLU H., AKDENİZ DOĞAN Z. D., BAYRAMİÇLİ M. N. Ü.Publication Metadata only Coupler cihazı ile yapılan anastomozlarda tromboemboli oranlarının karşılaştırılması(2020-10-22) AKDENİZ DOĞAN, ZEYNEP DENİZ; ÇAVUŞ ÖZKAN, MELEKBER; SAÇAK, BÜLENT; BAYRAMİÇLİ, MEHMET NURİ ÜMİT; AYDIN, CEM; AYDIN C., AKDENİZ DOĞAN Z. D., ÇAVUŞ ÖZKAN M., SAÇAK B., BAYRAMİÇLİ M. N. Ü.Giriş: Serbest doku aktarımlarında özellikle venöz anastomoz sırasında kullanılan coupler cihazları son dönemde büyük bir popülarite kazanmıştır. Literatürde bu cihazların güvenilirliği hakkında az sayıda çalışma bulunmaktadır. Kliniğimizde yapılmış serbest doku aktarımı olgularımızı retrospektif olarak inceleyerek Coupler cihazı ve dikiş ile yapılan anastomozlar arasındaki tromboz oranlarını karşılaştırdık. Bunun yanında venöz tromboza katkıda bulunabilecek diğer olası risk faktörlerini inceledik. Gereç ve Yöntem: Ocak 2015-Ağustos 2019 tarihleri arasında yapılan tüm mikrovasküler serbest doku aktarımlarının verileri retrospektif olarak incelendi. Hastaların demografik özellikleri, venöz anastomoz tipi (dikiş - coupler cihazı), rekonstrüksiyon yeri, radyoterapi, kemoterapi öyküsü ve tekrarlayan operasyon sayısı gibi özellikleri kaydedildi. Sonuçlar: Serbest doku aktarımı yapılan ardışık 385 hasta analiz edildi. Toplam venöz tromboz oranı % 4.7’ydi. Coupler cihazı kullanılarak yapılan anastomozlarla dikiş ile yapılan anastomozlar arasında venöz tromboemboli oranı açısından anlamlı bir fark saptanmadı (% 3.2 ve % 5.2, p = 0.58). Sadece rekonstrüksiyon bölgesinin venöz tromboz ile anlamlı olarak ilişkili olduğu tespit edildi (p = 0.03). Tartışma: Farklı rekonstrüksiyon alanlarını ve çok sayıda flep tipini içeren sonuçlarımız, Coupler cihazı ve dikiş ile yapılmış anastomozlar arasında revizyon oranlarının benzer olduğunu göstermektedir. Bu bulgu mevcut literatürle uyumludurPublication Metadata only The Efficacy of Hydrodilatation for the Prevention of Vasospasm following Microsurgical Anastomosis(THIEME MEDICAL PUBL INC) BAYRAMİÇLİ, MEHMET NURİ ÜMİT; Serin, Merdan; Bayramicli, Mehmet; Cilingir Kaya, Ozlem Tugce; Levent, Hilal Nisva; Akdeniz Dogan, Zeynep Deniz; Ercan, Alp; Kurt Yazar, SevgiIntroduction Vasospasm is a major problem following microsurgical reconstruction which can result in the partial or complete loss of the flap tissue. The aim of this study was to investigate the efficiency of hydrodilatation for the prevention of vasospasm. Material and Methods Thirty male Wistar rats were used for this experimental study. Femoral arteries of were exposed, photographed, and transected. In group 1, group 2, and group 3 papaverine solution, hydrodilatation, and minimal mechanical dilatation (control group) was performed, respectively. The anastomosis was completed and the arteries were photographed again 10minutes after completion of the anastomosis. Following 7-day period samples for transmission electron microscopy (TEM) and light microscopy were obtained. Results The mean vessel diameters prior to transection were 0.43, 0.45, and 0.52mm in the papaverine, hydrodilatation, and control groups, respectively. The mean vessel diameter 10minutes following the completion of anastomosis was 0.76, 0.75, and 0.51mm in the papaverine, hydrodilatation, and control groups, respectively. Median score for papaverine group regarding histological parameters of regular endothelial lining and lumen, neutrophil infiltration, vascular congestion, and edema in tunica adventitia was 2, 3, 2, and 3 positive, respectively. Median score for the papaverine group regarding histological parameters of regular endothelial lining and lumen, neutrophil infiltration, vascular congestion, and edema in tunica adventitia was 3, 3, 3, and 3 positive, respectively. All the histological scores were negative in the control group. The difference between the control group and the experiment groups 1 and 2 was significant regarding all four histological parameters ( p <0.05). Conclusion Hydrodilatation and papaverine application were both effective in preventing vasospasm following microsurgical intervention but papaverine caused slightly less damage to the endothelial lining and less edema in the tunica adventitia when compared with the hydrodilatation. Hydrodilatation group showed a vasodilatory effect that was statistically similar to that of papaverine, which has a proven efficacy.