Person: AKYÜZ, SERAP HATİCE
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AKYÜZ
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SERAP HATİCE
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Publication Metadata only Masticatory parameters of children with and without clinically diagnosed caries in permanent dentition(ARIESDUE SRL, 2017) AKYÜZ, SERAP HATİCE; Kaya, M. S.; Akyuz, S.; Guclu, B.; Diracoglu, D.; Yarat, A.Aim Mastication turns food into a bolus and prepares it for chemical digestion. Any condition affecting tooth structure and position may have an impact on mastication. The aim of this study is to compare masticatory performance (MP) and maximum bite force (MBF) between children with and without clinically visible caries in permanent first molars. Materials and methods The study was conducted with 50 children in good general condition aged 12-14 years (25 girls, 25 boys) with no orthodontic/skeletal anomalies and no missing teeth due to dental trauma or extraction. Maximum bite force was measured bilaterally using strain gauge sensors. Masticatory performance was evaluated by silicone tablet comminution test. Results Masticatory performance was superior in caries-free children when compared to children with caries. Maximum bite force values in children with and without caries were not statistically different. Conclusions Caries reduces masticatory performance. Therefore, treatment is crucial for masticatory efficiency.Publication Open Access INVESTIGATION OF THE N-TERMINAL CODING REGION OF MUC7 ALTERATIONS IN DENTISTRY STUDENTS WITH AND WITHOUT CARIES(MACEDONIAN ACAD SCIENCES ARTS, 2016-06-01) YARAT, AYŞEN; Ozturk, Koc L.; Yarat, A.; Akyuz, S.; Furuncuoglu, H.; Ulucan, K.Human low-molecular weight salivary mucin (MUC7) is a small, secreted glycoprotein coded by MUC7. In the oral cavity, they inhibit the colonization of oral bacteria, including cariogenic ones, by masking their surface adhesions, thus helping saliva to avoid dental caries. The N-terminal domain is important for low-molecular weight (MG2) mucins to contact with oral microorganisms. In this study, we aimed to identify the N-terminal coding region of the MUC7 gene between individuals with and without caries. Forty-four healthy dental students were enrolled in this study; 24 of them were classified to have caries [decayed, missing, filled-teeth (DMFT) = 5.6] according to the World Health Organization (WHO) criteria, and 20 of them were caries-free (DMFT = 0). Simplified oral hygiene index (OHI-S) and gingival index (GI) were used to determine the oral hygiene and gingival conditions. Total protein levels and salivary total protein levels and salivary buffer capacity (SBC) were determined by Lowry and Ericsson methods. DNA was extracted from peripheral blood cells of all the participants and genotyping was carried out by a polymerase chain reaction (PCR)-sequencing method. No statistical differences were found between two groups in the terms of salivary parameters, oral hygiene and gingival conditions. We detected one common single nucleotide polymorphism (SNP) that leads to a change of asparagine to lysine at codon 80. This substitution was found in 29.0 and 40.0%, respectively, of the groups with and without caries. No other sequence variations were detected. The SNP found in this study may be a specific polymorphism affecting the Turkish population. Further studies with extended numbers are necessary in order to clarify this finding.Publication Open Access Assessment of dental caries and salivary nitric oxide levels in children with dyspepsia(BMC, 2019-12) ALTURFAN, EBRU IŞIK; Aksit-Bicak, Damla; Emekli-Alturfan, Ebru; Ustundag, Unsal Veli; Akyuz, SerapBackground: The increase in nitric oxide (NO) levels in the oral cavity and saliva have been associated with various oral diseases; however, the gastro-salivary interaction of NO remains controversial. Thus, the aim of this study was to determine and compare salivary NO levels of dyspeptic and non-dyspeptic healthy children and to conduct an evaluation of its association with dental caries. Methods: Seventy children with dyspepsia (dyspeptic group) and 30 children without any gastrointestinal complaints (control group) were included in the study. Two biopsies from the gastric tissues were collected from dyspeptic children for histopathologic examination. Oral examination involved the assessment of dental caries, gingival index, plaque index, buffering capacity, salivary flow rate and pH. Salivary Streptococcus mutans (S. mutans) and Lactobacilli sp. counts were performed by commercial kits. For the comparison of the normal distribution between dyspeptic and control groups, Student t-test and for the comparison of the non-normal distribution, Kruskal-Wallis and Mann-Whitney-U tests were used. Chi-square test was used for comparison of qualitative data and the Pearson correlation test was used to evaluate the association between certain variables. Significance was assessed at p<0.05 level. Results: Helicobacter pylori (H.pylori) were found in gastric biopsies of 84.2% (59/70) of the dyspeptic children. While the mean salivary NO values did not differ significantly between gastric H.pylori positive, negative and control groups, the salivary NO level of the dyspeptic group (213.7 +/- 51.68 mu mol/dL) was found to be significantly higher than the control group (185.7 +/- 16.66 mu mol/dL). No significant relationship was found between the mean salivary NO values, DMFT/dmft numbers and other oral parameters. Conclusions: The association of dental caries and salivary NO levels could not be considered specific in the current study. Although there were no statistically significant differences between salivary NO levels of gastric H.pylori positive, gastric H.pylori negative and control groups, greater salivary NO levels among dyspeptic children compared with the control group demonstrated that the concentration of NO in the saliva could be used as a biological marker in dyspepsia, which could lead to the improvement of more specified, uncomplicated and susceptible methods for analysis.