Person: ŞEHİRLİ, ÜMİT SÜLEYMAN
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ŞEHİRLİ
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ÜMİT SÜLEYMAN
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Publication Open Access The effects of melatonin on the striatum(MARMARA UNIV, FAC MEDICINE, 2021-10-31) BORACI, HATİCE; Gergin, Sinem; Kirazli, Ozlem; Boraci, Hatice; Yildiz, Sercan Dogukan; Sehirli, Umit SuleymanObjective: Some of the neurological diseases cause morphologic changes in the striatal neurons. Medial forebrain bundle (MFB) lesion is a commonly used method to produce a Parkinsonian model rat. Melatonin is a hormone which exerts a neuroprotective effect on the neurons. The aim of this study is to investigate the effect of melatonin on the dendritic morphology of striatal medium spiny neurons (MSNs) in rats with MFB lesion. Materials and Methods: Twelve male Wistar albino rats were given saline injections into the MFB and divided into sedentary and treatment groups. The treatment group was administered a 10 mg/kg dose of melatonin intraperitoneally for 30 days. The lesion was confirmed histologically by Nissl staining. Golgi staining technique was applied to observe neuronal morphology. Neuronal structures were analysed from three-dimensional images by Neurolucida (MBF Bioscience) software. Results: The MFB lesion caused a reduction in the total dendritic length and in the number of dendritic endings. The melatonin enhanced the number of dendritic endings compared to the sedentary group. The melatonin led to an increase in the total spine density, spine densities of thin and mushroom types. Conclusion: Melatonin improved the dendritic degeneration due to MFB lesion.Publication Open Access The effects of regular swimming exercise and melatonin on the neurons localized in the striatum of hemiparkinsonian rats(2022-10-01) KİRAZLI, ÖZLEM; BORACI, HATİCE; YILDIZ, SERCAN DOĞUKAN; YANANLI, HASAN RACİ; ŞEHİRLİ, ÜMİT SÜLEYMAN; Gergin S., KİRAZLI Ö., BORACI H., YILDIZ S. D. , YANANLI H. R. , ŞEHİRLİ Ü. S.Parkinson's disease is a progressive neurodegenerative movement disorder. We aimed to investigate the effects of regular swimming exercise and melatonin applied in the 6-Hydroxydopamine-induced Parkinson's disease rats by analysing dendritic spine of striatal neurons. Twenty-four male Wistar albino rats were used. 6-Hydroxydopamine unilaterally injected four (control, exercise, melatonin and exercise + melatonin) groups were included in the study. Tyrosine hydroxylase expression was detected by immunohistochemistry. Neurons and structures were identified from three-dimensional images by Neurolucida software. There was not any apparent difference for tyrosine hydroxylase positive neurons in the substantia nigra pars compacta and fibres in the striatum between the lesion sides of hemiparkinsonian groups. The treatment groups blocked the apomorphine-induced increase in rotations compared to the control group. In stepping test, the treatment groups prevented the loss of stepping in the contralateral side of hemiparkinsonian groups. The melatonin mostly had a positive effect on motor activity tests. In morphological analyses, the 6-Hydroxydopamine-induced lesion led to the reduction of the total dendritic length and number of branches. In the treatment groups, the reduction of the dendritic parameters was not observed. 6-Hydroxydopamine lesion led to a decrease in the total spine density, spine densities of thin and mushroom types. The exercise and melatonin treatments prevented the loss of spine density. The exercise treatment prevented the loss of spine density of mushroom type spines. The melatonin treatment blocked the loss of spine density of stubby type. In conclusion, these results provide evidence for effective additional protective therapeutic strategies for Parkinson\"s disease. In conclusion, results from the current study provide evidence for swimming exercise and melatonin as a promising candidate for effective additional protective strategies for PD.Publication Open Access The Effect of Canagliflozin on Hippocampal Dendrite Morphology in a Model of Alzheimer's Disease Induced by Intracerebroventricular Injection of Streptozotocin(2023-10-01) YAZI, SEVDENUR; YANANLI, HASAN RACİ; ŞEHİRLİ, ÜMİT SÜLEYMAN; KİRAZLI, ÖZLEM; Yazı S., Özen B., Buldu B., Yalçın E., Karaköse O., Çakmak O., Somunkıran S., Yananlı H. R., Şehirli Ü. S., Kirazlı Ö.