Person: ŞEHİRLİ, ÜMİT SÜLEYMAN
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ŞEHİRLİ
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ÜMİT SÜLEYMAN
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Publication Metadata only Wistar ve genetik absans epilepsili (GAERS) sıçanlarda dendrit morfolojisinin incelenmesi(2021-11-21) YAZI, SEVDENUR; ŞEHİRLİ, ÜMİT SÜLEYMAN; GÜLHAN, REZZAN; KİRAZLI, ÖZLEM; Yazı S., Şehirli Ü. S., Gülhan R., Onat F., Kirazlı Ö.Publication Open Access The failure on the effectiveness of formalin on cadaver disinfection and alternative methods(2023-01-01) AKSU, MEHMET BURAK; ÖZKAN, MAZHAR; ŞEHİRLİ, ÜMİT SÜLEYMAN; Yanilmaz O., Guncu M. M., AKSU M. B., ÖZKAN M., ŞEHİRLİ Ü. S.Objective: It was aimed to identify the contaminant and determine the alternative disinfectant detection in the microbial growth observed in various parts of the cadaver stored in the formalin tank in the dissection laboratory of Marmara University Anatomy Department. We also performed a literature review of this unusual pathogen. Materials and Methods: Swab samples were inoculated on agar mediums. After incubation, matrix-assisted laser desorption ionizationtime of flight mass spectrometry (MALDI-TOF MS) analysis was used to identify the isolate from the detected uniform colonies. Sample solution from the cadaver tank, freshly prepared 5% formalin and 0.55% ortho-phthalaldehyde were used to determine the disinfectant sensitivity of the isolate. Results: According to 16s rDNA sequence analysis, it was concluded as Skermanella aerolata with 99% similarity. In the disinfectant susceptibility test, it was observed that S. aerolata and control bacteria could grow in 5% formalin taken from the cadaver tank. No growth was detected in other disinfectants. Conclusion: To prevent cadaver contamination in anatomy laboratories, the quality control of the embalming solutions and indoor air filtration of the dissection rooms should be checked at regular intervals. Members of Skermanella genus have been identified as environmental organisms in several studies, however, recent researches reported this bacterium as a human pathogen.Publication Open Access The effects of regular swimming exercise and melatonin on the neurons localized in the striatum of hemiparkinsonian rats(2022-10-01) KİRAZLI, ÖZLEM; BORACI, HATİCE; YILDIZ, SERCAN DOĞUKAN; YANANLI, HASAN RACİ; ŞEHİRLİ, ÜMİT SÜLEYMAN; Gergin S., KİRAZLI Ö., BORACI H., YILDIZ S. D. , YANANLI H. R. , ŞEHİRLİ Ü. S.Parkinson's disease is a progressive neurodegenerative movement disorder. We aimed to investigate the effects of regular swimming exercise and melatonin applied in the 6-Hydroxydopamine-induced Parkinson's disease rats by analysing dendritic spine of striatal neurons. Twenty-four male Wistar albino rats were used. 6-Hydroxydopamine unilaterally injected four (control, exercise, melatonin and exercise + melatonin) groups were included in the study. Tyrosine hydroxylase expression was detected by immunohistochemistry. Neurons and structures were identified from three-dimensional images by Neurolucida software. There was not any apparent difference for tyrosine hydroxylase positive neurons in the substantia nigra pars compacta and fibres in the striatum between the lesion sides of hemiparkinsonian groups. The treatment groups blocked the apomorphine-induced increase in rotations compared to the control group. In stepping test, the treatment groups prevented the loss of stepping in the contralateral side of hemiparkinsonian groups. The melatonin mostly had a positive effect on motor activity tests. In morphological analyses, the 6-Hydroxydopamine-induced lesion led to the reduction of the total dendritic length and number of branches. In the treatment groups, the reduction of the dendritic parameters was not observed. 6-Hydroxydopamine lesion led to a decrease in the total spine density, spine densities of thin and mushroom types. The exercise and melatonin treatments prevented the loss of spine density. The exercise treatment prevented the loss of spine density of mushroom type spines. The melatonin treatment blocked the loss of spine density of stubby type. In conclusion, these results provide evidence for effective additional protective therapeutic strategies for Parkinson\"s disease. In conclusion, results from the current study provide evidence for swimming exercise and melatonin as a promising candidate for effective additional protective strategies for PD.Publication Open Access The Effect of Canagliflozin on Hippocampal Dendrite Morphology in a Model of Alzheimer's Disease Induced by Intracerebroventricular Injection of Streptozotocin(2023-10-01) YAZI, SEVDENUR; YANANLI, HASAN RACİ; ŞEHİRLİ, ÜMİT SÜLEYMAN; KİRAZLI, ÖZLEM; Yazı S., Özen B., Buldu B., Yalçın E., Karaköse O., Çakmak O., Somunkıran S., Yananlı H. R., Şehirli Ü. S., Kirazlı Ö.Publication Metadata only Intraserebroventriküler streptozosin enjeksiyonu ile oluşturulmuş Alzheimer modelinde kanagliflozin'in Hipokampus dendrit morfolojisi üzerine etkisi(2023-06-08) YAZI, SEVDENUR; YANANLI, HASAN RACİ; ŞEHİRLİ, ÜMİT SÜLEYMAN; KİRAZLI, ÖZLEM; Yazı S., Özen B., Buldu B., Yalçın E., Karaköse O., Çakmak O., Somunkıran S., Yananlı H. R., Şehirli Ü. S., Kirazlı Ö.