Person: CİNEL, ZELİHA LEYLA
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CİNEL
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ZELİHA LEYLA
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Publication Open Access Adenoid ‘ameloblastoma: Clinicopathological description of 4 additional BRAF-negative cases(2023-12-01) CİNEL, ZELİHA LEYLA; Khalaj F., CİNEL Z. L., Aminishakib P., Mosavat F., SOLUK TEKKEŞİN M.Objective: Adenoid ameloblastoma (AA) is an epithelial odontogenic tumor that was recognized as a separate entity in the last odontogenic classification of WHO in 2022. The etiology is unknown, and the pathogenesis remains controversial. The objective of this study is to contribute the clinicopathological features of 4 additional BRAF-negative cases to the existing literature, aiming to enhance the molecular understanding of this unique tumor in the forthcoming classification. Materials and methods: This study consists of a case series of four patients diagnosed with AA. The patients’ demographic and clinical information were collected from the universities’ medical achieves. Histopathologically, all cases were reexamined according to the latest update of the WHO odontogenic tumor classification. In addition to H&E and immunohistochemical stains, cytogenetics was also evaluated. Results: Well-defined unilocular radiolucent lesions were observed in all cases. Ameloblastoma-like components exhibited reserved nuclear polarity, suprabasal stellate reticulum-like epithelium, duct-like structure, whorls/morules, and cribriform architecture were common features. Variable immunoreactivity to CK7, CK19, CK14, p63, and p40 were determined, and proliferative activity was greater than 15%. The BRAF molecular study revealed no mutations. Conclusions: When diagnosing AA, the essential histopathological characteristics must be rigorously applied, and a significant portion of the lesion should contain these features. Additionally, despite limited molecular data, since the BRAF mutation commonly observed in ameloblastomas is not present in the majority of AA cases, we propose changing the term \"ameloblastoma\" to \"ameloblastic\" and referring to it as \"adenoid ameloblastic tumor\" in the forthcoming classification.Publication Metadata only Schneiderian type papilloma of the middle ear(2020-12-01) CİNEL, ZELİHA LEYLA; Keskin B., CİNEL Z. L.Publication Open Access The promising role of Gelsolin expression to predict survival in patients with squamous cell carcinoma of the larynx(2021-06) BATMAN, ABDULLAH ÇAĞLAR; Şahin, Akın; Enver, Necati; Erçetin, Selim Yiğit; Cinel, Zeliha Leyla; Batman, Abdullah ÇağlarPublication Metadata only Baş-boyun spesimenleri patolojik değerlendirme ve raporlama rehberi(buluş, 2021-03-01) CİNEL, ZELİHA LEYLA; Cinel Z. L., Gökcan M. K., Veral A., Çomunoğlu N., Soluk Tekkeşin M.Publication Metadata only Immunomodulatory and Tissue-preserving Effects of Human Dental Follicle Stem Cells in a Rat Cecal Ligation and Perforation Sepsis Model(ELSEVIER SCIENCE INC, 2020) GÜL, FETHİ; Sarica, Leyla Topcu; Zibandeh, Noushin; Genc, Deniz; Gul, Fethi; Akkoc, Tolga; Kombak, Erdem Faruk; Cinel, Leyla; Akkoc, Tunc; Cinel, IsmailBackground. Mesenchymal stem cells may be used for the treatment of sepsis. Dental follicle stem cells (DFSCs) are easily accessible but have not been studied in vivo or in clinical trials in sepsis models. Aim of the study. We aim to elucidate DFSC effects on host immunological functions in a rat cecal ligation and perforation (CLP) sepsis model. Methods. Adult male rats were categorized into group 1 (sham procedure SP), group 2 (SP + 1 x 10(6) DFSCs administered 0 h after SP), group 3 (CLP + saline), group 4 (CLP 1 x 10(6) DFSCs administered 0 h after CLP), and group 5 (CLP + 1 x 10(6) DFSCs administered 4 h after CLP). Green fluorescent protein-labeled cells were used for imaging. Histopathological examination of ileal tissues was performed. Results. A significant increase in the percentage of CD4+/CD25+/Foxp3+ Treg cells in groups 4 and 5 occurred compared with that in group 3. No significant changes in CD3+/CD4+ helper T-cells and CD3+/CD8+ cytotoxic T-cells were observed. Treatment with DFSCs at 4 h significantly decreased the level of TNF-alpha compared with that in group 3. No significant changes in IL-10 levels and lymphocyte proliferation suppression were observed. During histopathological examination, no high scoring (Chiu scores: 3 or 4) rats were observed in the curative treatment group (group 5). Conclusions. Treatment with DFSC after 4 h of sepsis induction downregulates tissue inflammatory responses by decreasing TNF-alpha levels and increasing Treg cell ratio. This also has a protective effect on intestinal tissues during sepsis. (C) 2020 IMSS. Published by Elsevier Inc.Publication Open Access Primary Cutaneous Adenoid Cystic Carcinoma(2020) KESKİN ÖZTÜRK, BEYZA; Caner KAYA;F. Nihal DURMUŞ KOCAASLAN;Zeliha Leyla CİNEL;Beyza KESKİN;Özhan ÇELEBİLERAdenoid cystic carcinoma is a malignant tumor usually localized in the salivary glands. It can also develop in serous glands such as the breast, main bronchi, uterine cervix, Bartholin's gland of the vulva, prostate gland, and external auditory canal. It is more common in the white race. Most of the primary cutaneous adenoid cystic carcinoma cases occur on the scalp. Despite the high rate of metastasis, long-term survival can be observed because the progression of the disease is slow. Distant organ metastases such as lungs, bone, liver and brain have also been reported in the literature at 40%. Its treatment is wide excision of the lesion and demonstration of tumor negative margin in pathological sampling. In this case report, we wanted to present surgical and oncological treatment to a 65-year-old female patient with lung metastasis diagnosed with adenoid cystic carcinoma on the scalp.Publication Open Access Clinicopathological features of trichoblastomas and malignant variant: trichoblastic carcinoma(MARMARA UNIV, FAC MEDICINE, 2021-05-26) CİNEL, ZELİHA LEYLA; Ozkan, Melekber Cavus; Cinel, Zeliha LeylaObjective: Trichoblastomas are rare benign tumors of the skin appendages with epithelial and mesenchyntal components that exhibit differentiation to the follicular germinative epithelium and particularly to the follicular stroma of the skin. Our aim was to contribute to already limited literature data in order to gain more insights into the treatment and follow-up of patients with this condition. Methods and Materials: A total of 9 patients with trichoblastoma and 1 patient with malignant trichoblastoma were surgically treated between 2016 and 2020 at the Department of Plastic, Reconstructive and Aesthetic Surgery, School of Medicine, Marmara University. Results: Of the 10 patients with trichoblastoma, 5 were female and 5 were male, with a median age of 49 years. The smallest and largest lesion lenghts were 0.4 and 2 cm, respectively. Seven lesions had developed in the head and neck region, while 2 were in the trunk One of our cases was a 45-year old female patient with a malignant trichoblastoma presented with a lesion in the right side of the lower lip. Conclusion: Trichoblastomas are rare tumors that affect both sexes equally and are seen most commonly in the head and neck region. Recurrence rates were found to be low when they were treated with negative surgical margins.Publication Metadata only A rare variant: adenomatoid ameloblastoma with dentinoid(2020-12-01) SAÇAK, BÜLENT; CİNEL, ZELİHA LEYLA; Keskin B., Tekkesin M. S., SAÇAK B., CİNEL Z. L.Publication Metadata only Low Density Granulocytes and Dysregulated Neutrophils Driving Autoinflammatory Manifestations in NEMO Deficiency(SPRINGER/PLENUM PUBLISHERS, 2022) ÖZEN, AHMET OĞUZHAN; Yilmaz, Naz Surucu; Eltan, Sevgi Bilgic; Kayaoglu, Basak; Geckin, Busranur; Heredia, Raul Jimenez; Sefer, Asena Pinar; Kiykim, Ayca; Nain, Ercan; Kasap, Nurhan; Dogru, Omer; Yucelten, Ayse Deniz; Cinel, Leyla; Karasu, Gulsun; Yesilipek, Akif; Sozeri, Betul; Kaya, Goksu Gokberk; Yilmaz, Ismail Cem; Baydemir, Ilayda; Aydin, Yagmur; Kahraman, Deniz Cansen; Haimel, Matthias; Boztug, Kaan; Karakoc-Aydiner, Elif; Gursel, Ihsan; Ozen, Ahmet; Baris, Safa; Gursel, MaydaNF-kappa B essential modulator (NEMO, IKK-gamma) deficiency is a rare combined immunodeficiency caused by mutations in the IKBKG gene. Conventionally, patients are afflicted with life threatening recurrent microbial infections. Paradoxically, the spectrum of clinical manifestations includes severe inflammatory disorders. The mechanisms leading to autoinflammation in NEMO deficiency are currently unknown. Herein, we sought to investigate the underlying mechanisms of clinical autoinflammatory manifestations in a 12-years old male NEMO deficiency (EDA-ID, OMIM #300,291) patient by comparing the immune profile of the patient before and after hematopoietic stem cell transplantation (HSCT). Response to NF-kB activators were measured by cytokine ELISA. Neutrophil and low-density granulocyte (LDG) populations were analyzed by flow cytometry. Peripheral blood mononuclear cells (PBMC) transcriptome before and after HSCT and transcriptome of sorted normal-density neutrophils and LDGs were determined using the NanoString nCounter gene expression panels. ISG15 expression and protein ISGylation was based on Immunoblotting. Consistent with the immune deficiency, PBMCs of the patient were unresponsive to toll-like and T cell receptor-activators. Paradoxically, LDGs comprised 35% of patient PBMCs and elevated expression of genes such as MMP9, LTF, and LCN2 in the granulocytic lineage, high levels of IP-10 in the patient's plasma, spontaneous ISG15 expression and protein ISGylation indicative of a spontaneous type I interferon (IFN) signature were observed, all of which normalized after HSCT. Collectively, our results suggest that type I IFN signature observed in the patient, dysregulated LDGs and spontaneously activated neutrophils, potentially contribute to tissue damage in NEMO deficiency.Publication Open Access Severe allergic dysregulation due to a gain of function mutation in the transcription factor STAT6(2023-01-01) BARIŞ, SAFA; YÜCELTEN, AYŞE DENİZ; BOZKURTLAR, EMİNE; CİNEL, ZELİHA LEYLA; AYDINER, ELİF; ÖZEN, AHMET OĞUZHAN; BARIŞ S., Benamar M., Chen Q., Catak M. C., Martínez-Blanco M., Wang M., Fong J., Massaad M. J., Sefer A. P., Kara A., et al.Background: Inborn errors of immunity have been implicated in causing immune dysregulation, including allergic diseases. STAT6 is a key regulator of allergic responses. Objectives: This study sought to characterize a novel gain-of-function STAT6 mutation identified in a child with severe allergic manifestations. Methods: Whole-exome and targeted gene sequencing, lymphocyte characterization, and molecular and functional analyses of mutated STAT6 were performed. Results: This study reports a child with a missense mutation in the DNA binding domain of STAT6 (c.1114G>A, p.E372K) who presented with severe atopic dermatitis, eosinophilia, and elevated IgE. Naive lymphocytes from the affected patient displayed increased TH2- and suppressed TH1- and TH17-cell responses. The mutation augmented both basal and cytokine-induced STAT6 phosphorylation without affecting dephosphorylation kinetics. Treatment with the Janus kinase 1/2 inhibitor ruxolitinib reversed STAT6 hyperresponsiveness to IL-4, normalized TH1 and TH17 cells, suppressed the eosinophilia, and improved the patient\"s atopic dermatitis. Conclusions: This study identified a novel inborn error of immunity due to a STAT6 gain-of-function mutation that gave rise to severe allergic dysregulation. Janus kinase inhibitor therapy could represent an effective targeted treatment for this disorder.