Person: ÇAM, MUHAMMET EMİN
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
ÇAM
First Name
MUHAMMET EMİN
Name
3 results
Search Results
Now showing 1 - 3 of 3
Publication Metadata only Investigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra(2022-01-01) ÇAM, MUHAMMET EMİN; TAŞKIN, TURGUT; Kirmizi Sonmez N. I. , Guler E., ÇAM M. E. , Ermanoglu M., Gurdal B., TAŞKIN T., Omurtag G. Z.© 2022 Marmara University Press.Epilepsy is a state characterized by sudden, recurrent epileptic seizures that are not initiated by an identifiable event. There are various studies has been shown that Hypericum species may be used for their anticonvulsant potentials. Besides, the relationship between anticonvulsant activity and antioxidant effect has already been shown in the literature. In the current study, H. triquetrifolium was investigated for the first time for its potential antioxidant and anticonvulsant potential using in vitro and in vivo test models. H. triquetrifolium extracts were tested with DPPH assay, FRAP assay, copper (II) ion reducing antioxidant capacity assay, and acetylcholinesterase inhibitory activity assay to understand their antioxidant potential. Especially, methanolic extract of H. triquetrifolium was shown the highest antioxidant activity. Moreover, a pentylenetetrazole (PTZ, 80 mg/kg, i.p.)-induced seizure model was conducted to analyze the anticonvulsant activities of H. triquetrifolium extracts in mice. In addition, this study revealed that H. triquetrifolium decreased the ratio of severe seizures and increased the mean onsite of mortality and survival rate in a dose-dependent manner. It is thought that the anticonvulsant effect may be either related to the antioxidant potential of H. triquetrifolium or its interference in the GABAergic system.Publication Metadata only Controlled release of donopezil-loaded polyvinyl alcohol (pva) microbubbles/nanoparticles using microfluidic t-junction device(2020-09-18) CESUR, SÜMEYYE; ÇAM, MUHAMMET EMİN; GÜNDÜZ, OĞUZHAN; Cesur S., Çam M. E., Gündüz O.Production of donepezil- loaded microbubble/nanoparticles for treatment of Alzheimer diseasePublication Metadata only Fabrication and characterization of achillea Iycaonica- loaded poly(Lactic Acid) nanofibers(2018-09-14) ÇAM, MUHAMMET EMİN; CESUR, SÜMEYYE; TAŞKIN, TURGUT; GÜNDÜZ, OĞUZHAN; Çam M. E., Cesur S., Taşkın T., Kabasakal L., Gündüz O.