Person: ALTAN, ERAY
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ALTAN
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ERAY
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Publication Open Access Investigation of 3D-printed chitosan-xanthan gum patches(2022-07-01) ALTAN, ERAY; GÜNDÜZ, OĞUZHAN; BİNGÖL ÖZAKPINAR, ÖZLEM; ALTAN E., Turker N., Hindy O. A., Dirican Z., Ozakpinar Ö., Demir A. U., Kalaskar D., Thakur S., GÜNDÜZ O.In this study, using a new polymer combination of Chitosan(CH)/Xanthan Gum(XG) has been exhibited for wound dressing implementation by the 3D-Printing method, which was fabricated due to its biocompatible, biodegradable, improved mechanical strength, low degradation rate, and hydrophilic nature to develop cell-mimicking, cell adhesion, proliferation, and differentiation. Different concentrations of XG were added to the CH solution as 0.25, 0.50, 0.75, 1, and 2 wt% respectively in the formic acid/distilled water (1.5:8.5) solution and rheologically characterized to evaluate their printability. The results demonstrated that high mechanical strength, hydrophilic properties, and slow degradation rate were observed with the presence and increment of XG concentration within the 3D-Printed patches. Moreover, in vitro cell culture research was conducted by seeding NIH 3T3 fibroblast cells on the patches, proving the cell proliferation rate, viability, and adhesion. Finally, 1% XG and 4% CH containing 3D-Printed patches were great potential for wound dressing applications.Publication Open Access Marine-derived bioceramics for orthopedic, reconstructive and dental surgery applications(2022-11-01) OKTAR, FAİK NÜZHET; ÜNAL YILDIRIM, SEMRA; GÜNDÜZ, OĞUZHAN; EKREN, NAZMİ; ALTAN, ERAY; OKTAR F. N. , Unal S., GÜNDÜZ O., Ben Nissan B., Macha I. J. , Akyol S., Duta L., EKREN N., ALTAN E., YETMEZ M.Bioceramics are a fast-growing materials group, which are widely used in orthopedics, maxillofacial, dental, and reconstructive surgeries. They are produced using raw materials either from synthetic or natural sources. As naturally originated resources, the bones of sheep and cows are used after converting to calcium phosphates. Human-originated sources in the past were obtained from human cadaver bones, however now-a-days this has been discontinued. On the other hand, the \"golden standard\" in the reconstruction surgery has been using patients own bones, -i.e., autogenous bones, which heal better than other alternatives. Besides natural products, synthetic materials are produced from a range of inorganic raw and natural materials based on marine sources, such as corals, and other marine-derived materials (i.e., seashells, nacre). These are used to produce bioceramics and hence implants, devices, and bone grafts. Although during the last four decades a number of excellent books and book chapters have been published, no comprehensive review has been yet reported to cover the available marine materials and to indicate the related work and corresponding references to allow for both medical and ceramic scientists to access directly and open new avenues for further research on marine structures and their applications in orthopedic, maxillofacial, and reconstructive surgery areas. Hence, this review covers the general marine structures, their locations and availability in different countries and, current research on production methods of these unique structures that are difficult to fabricate synthetically. The authors are confident that this comprehensive review will be an excellent source not only for the ceramists, but also for the medical scientists.Publication Open Access Fabrication of electrospun juglans regia (juglone) loaded poly(lactic acid) scaffolds as a potential wound dressing material(2022-05-01) ALTAN, ERAY; ŞAHİN, ALİ; GÜNDÜZ, OĞUZHAN; ULAĞ, SONGÜL; ALTAN E., Karacelebi Y., Saatcioglu E., ULAĞ S., ŞAHİN A., AKSU M. B., Croitoru A., Codrea C. I., Ficai D., GÜNDÜZ O., et al.Juglone (5-hydroxy-1,4-naphthoquinone) (J) is a naphthoquinone structured allelochemical that is mostly found in the roots, leaves, nut-hulls, bark, and wood of walnut (Juglans regia). In this study, the biocompatibility, mechanical, thermal, chemical, morphological, and antimicrobial properties of the poly(lactic acid) (PLA) (w/v)/J (10, 20, 30 mg) electrospun scaffolds were investigated. Based on the results of the study, it was shown that juglone addition increased the antimicrobial properties of the scaffolds against the Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), compared to the neat PLA film after 24 h of contact time. According to the tensile test results, the addition of J made the scaffolds more flexible but decreased the mechanical strength. The cytotoxicity properties of the J-added scaffolds demonstrated a toxic behavior on the first day of incubation. However, with an increase in the J ratio, the fibroblast cell metabolic activity increased for all incubation periods.Publication Open Access Effects of temperature and pH on the synthesis of nanohydroxyapatite powders by chemical precipitation(2023-01-01) ALTAN, ERAY; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Mahmutoglu G., Topsakal A., ALTAN E., KUŞKONMAZ N., DAĞLILAR S., OKTAR F. N., Erdemir G., Kuruca S. E., AKYOL S., GÜNDÜZ O., et al.Bone tissue engineering is based on a comprehensive understanding of bone structure, bone mechanics, and biology. In order to create nanostructured hydroxyapatite powders with customized properties, many synthesis strategies such as wet chemical precipitation, sol-gel, hydrothermal, and biomimetic approaches have been intensively researched through the years. Calcium phosphate (CaP)-based ceramic nanoparticles, including hydroxyapatite (HAp), were synthesized by the chemical precipitation technique at pH ranges of 7 to 11 and different calcination temperatures of 600 to 1100 °C. The synthesized powders were characterized by several techniques, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), energy dispersive X-ray analysis (EDX), and in vitro cell culture assays. The particle size analysis and zeta potential of these powders were also carried out using the dynamic light scattering (DLS) and laser Doppler electrophoresis methods. The results showed that the pH levels of 9 to 11 range and calcination temperatures of 600 to 800 °C were adequate for appropriate nanohydroxyapatite powder production using this method. The particle size of the nanohydroxyapatite was approximately 55 nm, although they were agglomerated after calcination. The biocompatibility tests demonstrated that these nanohydroxyapatite (nHAp) powders produced have appropriate cytocompatibility and can be used for bone graft production and other biomedical applications.