Person: GÜNDÜZ, OSMAN HAKAN
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GÜNDÜZ
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OSMAN HAKAN
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Publication Metadata only Early-onset hemochromatic arthropathy in a patient with idiopathic hypermobility syndrome(SPRINGER-VERLAG, 2003) GÜNDÜZ, OSMAN HAKAN; Ofluoglu, D; Gunduz, OH; Ozaras, N; Kayhan, OHemochromatosis is a genetic disease related to human leukocyte antigen (HLA) A3, B7, and B14 histocompatability antigens resulting in increased iron absorption from the gastrointestinal tract and deposition of iron in tissues. Arthropathy is not uncommon in the late stage of disease. Characteristic radiologic findings are commonly observed in the wrists and metacarpophalangeal joints as well as the hips, knees, and ankle joints. Presented here is a 34-year-old male with hemochromatosis and bilateral shoulder, knee, and ankle pain. Radiologic examination revealed osteoarthritic findings in both ankle joints and chondrocalcinosis in the knee joints. All the major criteria of hypermobility syndrome were observed on physical examination. The early-onset arthropathy seen with this hemochromatosis is thought to result from hypermobility syndrome.Publication Metadata only The relationships of motor-evoked potentials to hand dexterity, motor function, and spasticity in chronic stroke patients: a transcranial magnetic stimulation study(SPRINGER HEIDELBERG, 2016) AKYÜZ, GÜLSEREN DERYA; Cakar, Engin; Akyuz, Gulseren; Durmus, Oguz; Bayman, Levent; Yagci, Ilker; Karadag-Saygi, Evrim; Gunduz, Osman HakanThe standardization of patient evaluation and monitoring methods has a special importance in evaluating the effectiveness of therapeutic methods using drugs or rehabilitative techniques in stroke rehabilitation. The aim of this study was to investigate the relationships between clinical instruments and transcranial magnetic stimulation (TMS)-evoked neurophysiological parameters in stroke patients. This study included 22 chronic post-stroke patients who were clinically assessed using the Motricity Index (MI), finger-tapping test (FTT), Motor Activity Log (MAL) 28, Brunnstrom motor staging and Ashworth Scale (ASH). Motor-evoked potential (MEP) latency and amplitude, resting motor threshold (rMT) and central motor conduction time (CMCT) were measured with TMS. Shorter MEP-latency, shorter CMCT, higher motor-evoked potential amplitude, and diminished rMT exhibited significant correlations with clinical measures evaluating motor stage, dexterity, and daily life functionality. rMT exhibited a negative correlation with hand and lower extremity Brunnstrom stages (r = -0.64, r = -0.51, respectively), MI score (r = -0.48), FTT score (r = -0.69), and also with amount of use scale and quality of movement scale of MAL 28 scores (r = -0.61, r = -0.62, respectively). Higher MEP amplitude and diminished rMT showed positive correlations with reduced ASH score (r = -0.65, r = 0.44, respectively). The TMS-evoked neurophysiologic parameters including MEP latency, amplitude, rMT and CMCT generally have positive correlation with clinical measures which evaluate motor stage, dexterity and daily life functionality. Additionally, spasticity has also remarkable relationships with MEP amplitude and rMT. These results suggest that TMS-evoked neurophysiological parameters were useful measures for monitoring post-stroke patients.Publication Metadata only Predictive factors for treatment success of transforaminal epidural steroid injection in lumbar disc herniation-induced sciatica(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2020) GÜNDÜZ, OSMAN HAKAN; Sencan, Savas; Celenlioglu, Alp Eren; Asadov, Ruslan; Gunduz, Osman HakanBackground/aim: The aim of this study was to identify predictive factors for treatment success in transforaminal epidural steroid injection in patients with lumbar disc herniation-induced sciatica. Materials and methods: A total of 219 patients who were diagnosed with unilateral sciatica and underwent transforaminal epidural steroid injections at the level of L4-5, L5-S1, or S1 neural foramina between March 2016 and May 2018 were retrospectively analyzed. The presence of transitional vertebrae and the grade of nerve root compression were evaluated by a radiologist. Data including age, sex, body mass index, duration of symptoms, injection levels, and pain scores were recorded. Pain scores were evaluated using the numerical rating scale. Treatment success was defined as a >= 50% decrease in pain scores at 3 months. Results: The study included 118 female and 101 male patients with a mean age of 43.65 +/- 12.18 years. The mean duration of symptoms was 25.64 +/- 2.17 weeks. Although the duration of symptoms was longer in patients for whom treatment failed, it did not reach statistical significance. Decreased pain scores at 1 h had a significant effect on treatment success (p = 0.012, odds ratio (OR): 1.015, 95% confidence interval (CI), 1.003-1.026). Conclusions: Our study results suggest that a decreased pain score at 1 h is a predictor for a favorable three-month response to transforaminal epidural steroid injection in patients with lumbar disc herniation-induced sciatica.Publication Metadata only A method for determining the grade of osteoporosis based on risk factors in postmenopausal women(SPRINGER LONDON LTD, 2005) AKYÜZ, GÜLSEREN DERYA; Ofluoglu, D; Gunduz, OH; Bekirolu, N; Kul-Panza, E; Akyuz, GThe aim of this study was to determine whether the probability of osteoporosis and osteopenia was affected by the risk factors, physical examination findings, or radiological investigations such as spinal X-rays in postmenopausal women. We assessed risk factors such as use of hormone replacement therapy, physical activity level, calcium intake, smoking, caffeine consumption, long-term immobilization, previous history of fracture, family history of fracture, presence of certain systemic diseases (hyperthyroidism or hyperparathyroidism), or use of medications (corticosteroids or others), physical examinations, and presence of vertebral fractures on spinal X-rays. Patients' bone mineral density (BMD) was evaluated using dual energy X-ray absorptiometry (DXA) in the lumbar spine, and we compared the risk factors between osteopenic and osteoporotic women according to DXA. We evaluated 235 postmenopausal women who attended our osteoporosis outpatient clinic. Those patients were divided into two groups as either osteopenic (n=67, mean age: 63.1 years) or osteoporotic (n=168, mean age: 66.2 years) according to WHO criteria. The lumbar spinal (L1-L2) T-score values were -1.5 +/- 0.6 and -3.1 +/- 0.6 in osteopenic and osteoporotic groups, respectively. There were significant differences between the two groups in terms of mean age and lumbar BMD (p=0.009 and p < 0.001, respectively). We also observed that vertebral tenderness on palpation, back pain, and existing vertebral fracture (fx) were significantly different between the osteopenic and osteoporotic groups (p < 0.05). As a result of the statistical analysis, we found an equation to determine osteopenic and osteoporotic women by using those four factors (age, vertebral tenderness on palpation, back pain, and existing vertebral fx) in multivariate stepwise logistic regression. The equation is as follows: Y (DXA) = -2.9024 + 0.044 (age in year) + 0.819 (vertebral fx) + 0.877 (pain) + 1.136 (vertebral tenderness). We can estimate whether a postmenopausal woman is osteopenic or osteoporotic based on these risk factors by using the stepwise logistic regression equation.Publication Metadata only In reply: Variability in coccygeal dynamic mobility in different populations(SAGE PUBLICATIONS INC, 2020-04) GÜNDÜZ, OSMAN HAKAN; Sencan, Savas; Cuce, Isa; Karabiyik, Ozgur; Demir, Fatma Gul Ulku; Ercalik, Tulay; Gunduz, Osman HakanPublication Metadata only Does facet tropism negatively affect the response to transforaminal epidural steroid injections? A prospective clinical study(SPRINGER, 2019) GÜNDÜZ, OSMAN HAKAN; Celenlioglu, Alp Eren; Sencan, Savas; Gunduz, Osman HakanObjectiveTo examine the impact of the presence of facet tropism on the results of transforaminal epidural steroid injection for unilateral radicular pain induced by lumbar disc herniation.Materials and MethodsWe included 112 patients diagnosed with unilateral, single-level lumbar disc herniation-induced radicular pain. Injection was planned at relevant levels. The patients were assessed using the Numerical Rating Scale, the Modified Oswestry Disability Index, and the Beck Depression Inventory before the injection and at hour 1, week 3, and month 3 after the injection. Presence of facet tropism was assessed by measuring the facet angles in the L3-4, L4-5, and L5-S1 segments of lumbar MRI T2 sequence axial section.ResultsA significant decrease in the Numerical Rating Scale and an increase in the Modified Oswestry Disability Index scores were detected at all follow-ups in groups comprising 39 patients with and 61 without facet tropism (p<0.05). On comparison, improvement in clinical parameters at week 3 and month 3 in the group without facet tropism was greater (p<0.05). As treatment success is considered to be a 50% reduction in the Numerical Rating Scale scores, 55.2% of the patients attained treatment success at month 3. Further, although the treatment success rate in the group with facet tropism was 34.2%, it was 69% in that without facet tropism (p<0.05).ConclusionFacet tropism correlates with less success of transforaminal epidural steroid injection; therefore, facet tropism may be a worthwhile measurement in a discussion with patients of the benefits of the procedure.Publication Metadata only Ganglion Impar block improves neuropathic pain in coccygodynia: A preliminary report(ELSEVIER URBAN & PARTNER SP Z O O, 2018) GÜNDÜZ, OSMAN HAKAN; Sencan, Savas; Kenis-Coskun, Ozge; Demir, Fatma Gul Ulku; Cuce, Isa; Ercalik, Tulay; Gunduz, Osman HakanAim of the study: To define the effectiveness of ganglion Impar block in improving neuropathic pain. Materials and methods: Patients who had pain around the coccyx for more than three months and did not respond to conservative treatment were included in this study. All the patients underwent fluoroscopy guided transsacrococcygeal ganglion Impar block with injecting 3 mL of 0.5% bupivacaine, 2 mL saline, and 1 mL (40 mg) of methylprednisolone. Patients were evaluated with visual analog scale (VAS) for pain, Leeds assessment of neuropathic symptoms and signs scale (LANSS) for neuropathic pain, Beck depression Inventory (BDI) for mood and Short-form 12 (SF-12) for quality of life before, 1 month 3 months and 6 months after the injection. Patients' painless sitting duration was also recorded. Results: A total of 28 patients were included in the final analyses. VAS and LANSS scores improved significantly throughout the follow-up periods. BDI scores also improved while SF-12 scores did not show significant changes. Painless sitting period of the patients' improved significantly. Conclusions: Ganglion Impar block is effective in decreasing the neuropathic component of chronic coccygodynia. This improves painless sitting in patients but its reflections on quality of life is not clear. (C) 2018 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.Publication Metadata only Complex Regional Pain Syndrome(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2011) GÜNDÜZ, OSMAN HAKAN; Kishner, Stephen; Rothaermel, Brett J.; Munshi, Satvik B.; Malalis, Jacinthe V.; Gunduz, Osman HakanComplex regional pain syndrome (CPRS) is a neuropathic pain disorder that can develop as a result of trauma, surgery or nerve injury, but many times no precipitating event is known. The pain is described as severe, constant, burning and/or deep aching. The hallmark of CRPS is pain and mobility problems disproportionate to the initial injury. Clinical features can include spontaneous limb pain, changes in skin color and temperature, swelling, vasomotor instability and autonomic dysfunction. The pathophysiology is not well understood, although progress is being made in better understanding the underlying mechanisms. The diagnosis of CRPS is generally clinical, but there are tests and procedures that may help support the diagnosis. The general awareness of CRPS is poor, and well-accepted treatment guidelines are lacking. Treatment should involve an interdisciplinary approach involving functional rehabilitation, pain management, and psychological treatment. Quality evidence supports the use of some medications. Other adjuvant therapies and more invasive treatments exist for refractory cases. Turk J Phys Med Rehab 2011;57:156-64.Publication Metadata only The relation between tooth loss and bone mass in postmenopausal osteoporotic women in Turkey: a multicenter study(SPRINGER JAPAN KK, 2003) AKYÜZ, GÜLSEREN DERYA; Gur, A; Nas, K; Kayhan, O; Atay, MB; Akyuz, G; Sindal, D; Aksit, R; Oncel, S; Dilsen, G; Cevik, R; Gunduz, OH; Ersoy, Y; Altay, Z; Ozturk, C; Akkus, S; Senocak, O; Kavuncu, V; Kirnap, M; Tekeoglu, I; Erdogan, F; Sarac, AJ; Demiralp, L; Demirkesen, A; Adam, MThe purpose of this study was to investigate the associations of tooth loss with skeletal bone mass, years since menopause, educational level, current smoking status, dietary calcium intake, and number of pregnancies in postmenopausal osteoporotic women in Turkey. The study population consisted of 1171 postmenopausal women aged 40-86 years (mean age, 61.19 +/- 7.28 years). A detailed history was obtained from all women, including relevant lifestyle parameters, risk factors, and measurements of weight and height. Women were separated into three groups according to the number of teeth remaining as group 1 (edentulous, 457 women), group 2 (10 or fewer teeth, 232 women), and group 3 (more than 10 teeth remaining, 482 women). There was no significant difference among the three groups in mean age and menopausal age (P < 0.05). Body mass index of group 1 was significantly higher than that of group 2 (P < 0.01). Educational level was significantly different between three groups: groups 1 and 2 (P < 0.001), groups 1 and 3 (P < 0.0001), and groups 2 and 3 (P < 0.001). Educational level was lowest in group 1 and highest in group 3. Despite a low ratio of cigarette smoking in general, a smoking habit was most prevalent in group 3 and least in group 2. The ratio of women receiving adequate calcium was significantly lower in group 1 than in other groups (P < 0.001); mean calcium intake was similar in all groups. The number of pregnancies was significantly higher in group 1 than in other groups (P < 0.001). Lumbar bone mineral density (BMD) of group 1 was significantly lower than that of groups 2 and 3 (P < 0.001). Although no significant difference was found between groups 1 and 3, femoral neck BMD of group 2 was less than in others, and differences between groups 1 and 2 and between groups 2 and 3 (P < 0.001) were significant. Lumbar bone mineral content (BMC) of group 1 was significantly lower than that of groups 2 and 3 (P < 0.001), and lumbar BMC in group 2 was significantly higher than in group 3 (P < 0.05). Femoral neck BMC in group 1 was significantly higher than in groups 2 and 3 (P < 0.001). In conclusion, lumbar BMD and BMC in the edentulous group were significantly lower, whereas femoral neck BMD and BMC were significantly higher in edentulous group compared with the others. Our findings indicated that improvement in lifestyle factors and nutritional strategies for the treatment and prevention of osteoporosis may have additional benefit in reducing tooth loss.Publication Metadata only A case of drop foot due to piriformis syndrome(2015) GÜNDÜZ, OSMAN HAKAN; Yıldırım, Pelin; Guler, Tuba; Misirlioglu, Tugce Ozekli; Ozer, Tulay; Gunduz, Osman Hakan