Person: AKOĞLU, HALDUN
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AKOĞLU
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HALDUN
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Publication Metadata only Neoadjuvan kemoterapi uygulanan meme kanserli olgularda güvenli tümör-meme ucu mesafesini meme MR öngörebilir mi?(2022-02-24) UĞURLU, MUSTAFA ÜMİT; AKMERCAN, AHMET; BUĞDAYCI, ONUR; KAYA, HANDAN; AKOĞLU, HALDUN; GÜLLÜOĞLU, MAHMUT BAHADIR; UĞURLU M. Ü., AKMERCAN A., BUĞDAYCI O., KAYA H., AKIN TELLİ T., AKOĞLU H., GÜLLÜOĞLU M. B.Publication Metadata only Earliest electrocardiogram is golden for the diagnosis of Brugada Syndrome(W B SAUNDERS CO-ELSEVIER INC, 2013) DENİZBAŞI ALTINOK, ARZU; Celik, Omer Faruk; Akoglu, Haldun; Eroglu, Serkan; Onur, Ozge; Denizbasi, ArzuCardiac syncope can be classified as being either structural or dysrhythmogenic in origin, and it may be the only warning symptom of sudden cardiac death. One of the causes of dysrhythmic sudden cardiac death in young adults with structurally normal hearts is Brugada syndrome. Electrocardiogram (ECG) of Brugada syndrome is characterized by an ST-segment elevation in the right precordial leads. A 23-year-old man was presented to our emergency department (ED) with a history of syncope which has occurred 30 minutes before arrival and lasted for 10 minutes. Both physical and neurological examinations were unremarkable. Family history revealed coronary artery disease of his father and sudden death at 45. Initial ECG performed 3 minutes after his arrival showed a type 2 repolarization variant of Brugada syndrome. This pattern was reverted back to normal 5 minutes later and never showed up again on his future ECGs. In our case, it was only the earliest ECG that made the diagnosis possible since all future ECGs showed a perfectly normal pattern throughout the follow-up period. In all syncope patients, initial ECGs should be kept and filed to be reviewed again in case the primary physician is not competent enough for the evaluation of ECG.Publication Metadata only Adrenomedullin reduces the severity of cerulein-induced acute pancreatitis(ELSEVIER SCIENCE INC, 2007) DENİZBAŞI ALTINOK, ARZU; Onur, Ozge Ecmel; Guneysel, Ozlem; Akoglu, Haldun; Denizbasi, Arzu; Onur, EnderWe investigated the effect of Adrenomedullin (AM) on cerulein-induced acute pancreatitis in rats. AM treatment (100 ng/kg per rat, subcutaneous) after one hour of cerulein injection reduced the plasma amylase levels, pancreatic weight, pancreatic malondialdehyde (MDA) levels, and the severity of the lesions microscopically. These data suggest that AM has a protective effect on cerulein-induced acute pancreatitis. These could be due to anti-inflammatory properties of AM, inhibition of proinflammatory cytokine secretion, reducing the endothelial permeability increased by reactive oxygen species, endotoxins or cytokines. (C) 2007 Elsevier Inc. All rights reserved.Publication Metadata only Ultrasound-guided supracondylar radial nerve block for Colles Fractures in the ED(2016) AKOĞLU, HALDUN; Ünlüer, Erden Erol; Karagöz, Arif; Ünlüer, Seran; Koşargelir, Mehmet; Kizilkaya, Mehmet; Alimoğlu, Orhan; Akoğlu, Haldun; Aslan, CihanPublication Metadata only What is the optimal postoperative oral feeding timing protocol for thoracotomy patients? Prospective randomized clinical trial on postoperative complications(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2017) YILDIZELİ, BEDRETTİN; Evman, Serdar; Akoglu, Haldun; Yildizeli, Bedrettin; Batirel, Hasan Fevzi; Yuksel, MustafaBackground: This study aims to determine the optimal postoperative oral feeding initiating time with the lowest postoperative pulmonary complication rate in thoracotomy patients and compare cardiac and psychiatric complication rates caused by different feeding schemes. Methods: The study included 107 consecutive patients (84 males, 23 females; mean age 53.9 years; range 17 to 81 years) planned to undergo lung resection via elective thoracotomy for both benign and malignant pathologies in a single institution during a time period of two years. Patients were prospectively randomized into three groups according to postoperative oral intake initiation time: oral intake was initiated on the postoperative sixth hour in group 1, 24th hour in group 2, and when bowel functions resumed in group 3. Groups were then compared in terms of postoperative complication rates. Results: Groups were homogenous according to demographic properties. Twenty patients (18.7%) developed postoperative pulmonary complications: four (11.1%) in group 1, eight (22.2%) in each of groups 2 and 3. Median oral intake initiation time for group 3 was 47 hours (range 27 to 82 hours). There was no significant difference between the groups in terms of postoperative pulmonary and cardiac complications (p=0.358 and p=0.175, respectively). While postoperative incidence of delirium was significantly increased in group 3 (n=5, 14.3%, p=0.032), it was not observed in group 1 and it was observed in two patients (5.6%) in group 2. This complication was directly correlated with development of postoperative pulmonary complications (odds ratio=14.2; p=0.002). Conclusion: Early (sixth hour) initiation of postoperative oral feeding is not related with increased pulmonary complications. On the contrary, early initiation may enable rapid recovery of postoperative mental and physical conditions, prevent psychiatric disorders, and reduce pulmonary complication rates. Thus this scheme can be administrated safely in all thoracotomy patients without potential risk for preoperative aspiration.Publication Metadata only INITIAL AND SUSTAINED RESPONSE EFFECTS OF 3 VAGAL MANEUVERS IN SUPRAVENTRICULAR TACHYCARDIA: A RANDOMIZED, CLINICAL TRIAL(ELSEVIER SCIENCE INC, 2019) DENİZBAŞI ALTINOK, ARZU; Ceylan, Ezgi; Ozpolat, Cigdem; Onur, Ozge; Akoglu, Haldun; Denizbasi, ArzuBackground: For acute termination of supraventricular tachycardia (SVT), vagal maneuvers, including the standard Valsalva maneuver (sVM), modified Valsalva (mVM) maneuver, and carotid sinus massage (CSM), are first-line interventions. There is no criterion standard technique. Objective: This prospective, randomized study was aimed at analyzing the success rates of these 3 vagal maneuvers as measured by sustaining sinus rhythm at the fifth minute and SVT termination. Methods: We conducted this prospective, randomized controlled study in an emergency department (ED). We enrolled all the patients who were admitted to the ED and diagnosed with SVT. We randomly assigned them to 3 groups receiving sVM, mVM, and CSM and recorded the patients' responses to the vagal maneuvers and SVT recurrence after vagal maneuvers. Results: The study was completed with 98 patients. A total of 25 (25.5%) instances of SVT were initially treated successfully with vagal maneuvers. The success rate was 43.7% (14/32 cases) from mVM, 24.2% (8/33) for sVM, and 9.1 % (3/33) for CSM (p < 0.05). At the end of the fifth minute, only 12.2% (12/98) of all patients had sinus rhythm. Sinus rhythm persisted in 28.1% (9/32) of patients in the mVM group, 6.1% (2/33) of patients in the sVM group, and 3% (1/33) in the CSM group at the fifth minute (p < 0.05). Conclusion: mVM is superior to the CSM maneuver in terminating SVT and maintaining rhythm. We conclude that it is beneficial to use mVM, which is more effective and lacks side effects. (C) 2019 Elsevier Inc. All rights reserved.Publication Metadata only Covid-19 ilişkili izole korpus kallosum splenium enfarktı(2021-11-28) SANRI, ERKMAN; DENİZBAŞI ALTINOK, ARZU; AKOĞLU, HALDUN; ONUR, ÖZGE ECMEL; KARACABEY, SİNAN; Ünlü B., Altun M., ALTUNBAS E., ADANÇ M., SANRI E., KARACABEY S., AKOĞLU H., ONUR Ö. E., DENİZBAŞI ALTINOK A.Publication Metadata only The effects of adrenomedullin in traumatic brain injury(ELSEVIER SCIENCE INC, 2013) DENİZBAŞI ALTINOK, ARZU; Demir, Hasan; Onur, Ozge E.; Denizbasi, Arzu; Akoglu, Haldun; Eroglu, Serkan E.; Ozpolat, Cigdem; Akoglu, EbruTraumatic brain injury (TBI) is a common cause of death and disability throughout the world. A multifunctional peptide adrenomedullin (AM) has protective effects in the central nervous system. We evaluated AM in an animal model as a therapeutic agent that reduces brain damage after traumatic brain injury. A total of 36 rats was divided into 3 groups as sham, head trauma plus intraperitoneal (ip) saline, and head trauma plus adrenomedullin ip. The diffuse brain injury model of Marmarou et al. was used. Blood samples were taken from all groups at the 1st, 6th and 24th hours for analysis of TNF-alpha (tumor necrosis factor-alpha), IL-1 beta (interleukin-1 beta) and IL-6 (interleukin-6) levels. At the end of the study (at the 24th hour) a neurological examination was performed and half of the rats were decapitated to obtain blood and tissue samples, the other half were perfused transcardiacally for studying the histopathology of the brain tissue. There were no statistically significant changes in plasma levels of IL-1 beta, IL-6 and TNF-alpha relative to the sham group. Also, changes in tissue levels of malonedialdehyde, myeloperoxidase and glutathione were not statistically significant. However, neurological scores and histopathological examinations revealed healing. AM individually exerts neuroprotective effects in animal models of acute brain injury. But the mechanisms of action remain to be assessed. (C) 2013 Elsevier Inc. All rights reserved.Publication Metadata only The utility of adding 1 l intravenous normal saline to standard 75 mg intramuscular diclofenac potassium injection in patients presented to the emergency department with an acute migraine attack: a randomizedcontrolled trial(2021-11-28) KARACABEY, SİNAN; AKOĞLU, HALDUN; SANRI, ERKMAN; ÖZPOLAT, ÇİĞDEM; DENİZBAŞI ALTINOK, ARZU; ONUR, ÖZGE ECMEL; Turan Y., AKOĞLU H., SANRI E., KARACABEY S., ÖZPOLAT Ç., ONUR Ö. E., DENİZBAŞI ALTINOK A.Publication Metadata only The middle cerebral artery density and ratio for the diagnosis of acute ischaemic stroke in the Emergency Department(WILEY, 2021) AKOĞLU, HALDUN; Baykal, Taygun; Akoglu, Ebru Unal; Akoglu, Tayfun; Ozturk, Tuba Cimilli; Akoglu, HaldunPurpose Non-contrast computed tomography (ncCT) is the first-line imaging modality for acute ischaemic stroke diagnosis. Recognition of the early diagnostic signs of a stroke on computed tomography (CT) is crucial. The hyperdense middle cerebral artery (MCA) sign is one of these findings. We investigated the diagnostic utility of absolute MCA density (MCAD) in patients with acute MCA stroke confirmed with diffusion-weighted magnetic resonance imaging (dwMRI). Methods We retrospectively included all patients who presented to the Emergency Department with symptoms related to an acute stroke and confirmed with a dwMRI and ncCT to this diagnostic case-control study. An expert radiologist with more than four years of experience in neuroradiology re-evaluated all ncCT images. The evaluation of MCAD and ratio were measured on axial images in Hounsfield units (HU). Results We included 407 patients in our study (MCA infarction: 55%, n = 225; Control: 45%, n = 182). We calculated the threshold for the highest sensitivity (20%) and specificity (94%) as 49 HU with the Youden J index test for MCAD and as 1.1 for MCAD ratio (sensitivity 20% and specificity 95%). MCAD >49 HU or MCAD ratio >1.1 alone or joint use of MCAD >47 HU and MCAD ratio >1.1 are useful markers to confirm the diagnosis of MCA AIS with a specificity of at least 94%. Higher MCAD values are associated with larger infarction volumes. Conclusion MCAD and MCAD ratio can be used to identify patients who need early treatment, especially in situations where computed tomography angiogram or dwMRI are not readily available.
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