Person: BEKİROĞLU, GÜLNAZ NURAL
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
BEKİROĞLU
First Name
GÜLNAZ NURAL
Name
24 results
Search Results
Now showing 1 - 10 of 24
Publication Open Access Sleep assessment in preterm infants: Use of actigraphy and aEEG(2022-11-01) BEKİROĞLU, GÜLNAZ NURAL; Ülgen Ö., Barış H. E. , Özbörü Aşkan Ö., Küçük Akdere S., Ilgın C., Özdemir H., Bekiroğlu G. N. , Gücüyener K., Özek E., Boran P.Objective: Objective methods to monitor the sleep of preterm infants at the neonatal intensive care unit (NICU) are required to prevent potentially adverse neurodevelopmental outcomes. This study aimed to determine the concordance of actigraphy and amplitude-integrated electroencephalogram (aEEG) against gold standard direct observation (DO) in assessing sleep/wake states of typically developing preterm infants. Methods: This prospective observational study was conducted in a single center level III NICU. Sleep variables were measured using Philips Respironics Mini-Mitter® Actiwatch-2 for 24 h and compared with 8-h matched data of aEEG and DO. Sensitivity-specificity analysis, Cohen's kappa, prevalenceadjusted and bias-adjusted kappa (PABAK), and Bland Altman plots were generated. Results: Seventeen preterm infants were recruited. A total of 11252 epochs were studied. Sensitivity (86.4%), agreement rate (67.9%), and predictive value for wake (47.9%) for the actigraphy were highest at the automatic activity threshold whereas specificity (54.5%) and predictive value for sleep (75.5%) were highest at low threshold. The sensitivity of aEEG was 79.3% and the specificity was 54.3%. At all thresholds, the agreement was largely equivalent with low kappas (0.14e0.17) and PABAK coefficients (0.22e0.35) for actigraphy and DO. Moderate agreement was observed between aEEG and DO according to the PABAK coefficient (0.44). Mean differences in sleep parameters were not different between DO and aEEG as well as DO/aEEG and actigraphy at medium threshold (p > 0.05). Conclusions: Actigraphy at medium threshold can be used in depicting sleep in typically developing preterm infants at NICU. aEEG may be an alternative adjunctive method to actigraphy for the evaluation of sleep/wake states in the NICU settingPublication Open Access Açık ve laparoskopik kolesistektominin erken postoperatif dönem sıvı faz mide boşalmasına etkileri (ön çalışma)(1996-06-01) BEKİROĞLU, GÜLNAZ NURAL; Günal Ö., Değirmencioğlu L., Çaşkurlu U., Akkaya L., Bekiroğlu G. N.Today, laparoscopic cholecystectomy (LC) as a gold standard operation in the treatment of the gallbladder stones, has not been known enough how it does effect to earty postoperative period (EPP) liquid phase gastric emptying, comparing with the open cholecystectomy (OC). Gastric empyting scintigraphy (Tc 99m-DPTA) has been done to 12 laparoscopically, 6 conventionally treated cholecystectomy patients in prospective, randomized manner. Pre-operative, postoperative 1st and 7th day scintigraphic gastric empyting values (GEVs) were compared with each other. As compared with OC, decreasing GEV in LC at post-op 1st day 60.min was found to be increased at 7th day 0. and 30. min. significantly (p<0.05). However, both LC and OC groups GEVs were found to be statistically the similar levels at 7th day 60. min. We could not find a clinically reasonable difference between the effects of LC and OC on the liquid phase gastric empyting.Publication Open Access Design and Validation of the Marmara Post-prostatectomy Incontinence Symptom Score(GALENOS YAYINCILIK, 2017-03-13) BEKİROĞLU, GÜLNAZ NURAL; Akgul, Murat; Sulukaya, Muhammed; Sahan, Ahmet; Bekiroglu, Nural; Tinay, Ilker; Turkeri, Levent; Tarcan, TufanObjective: This study aims to validate the Marmara post-prostatectomy incontinence symptom score (M-PPISS) designed for the assessment of post-prostatectomy incontinence (PPI). Materials and Methods: The questionnaire consists of 3 sections including 8 questions (4 questions examining the type and degree of PPI, 3 questions examining the effect of PPI on quality of life (QoL) and 1 question examining bladder emptying) and an analogue scale to assess the impact of PPI on the QoL. The questionnaire was completed by 106 patients, who underwent radical prostatectomy (RP) in our clinic between 2007 and 2015, at the end of the first week, first month and at 3-month intervals up to one year after RP. Results: The mean score of 106 patients at the end of the first week after the operation was 6.57 (minimum: 0, maximum: 24). The internal consistency coefficient measured for our questionnaire was found to be higher (Cronbach's alpha: 0.887). When an item was deleted, Cronbach's alpha was not lower than 0.85 for any value. According to the 27% rule, p value was calculated as 0.0001. In the numerical evaluation of total score and the analogue scale considering QoL (satisfaction and dissatisfaction); patients with a total score of 0-4 were accepted as satisfied with QoL, while patients with a total score of >= 5 were included in the dissatisfied group (cut-off value: 5). Conclusion: The M-PPISS was found to be a reliable and valid instrument in the evaluation of urinary incontinence after RP.Publication Open Access Postoperative psychiatric disorders in general thoracic surgery: incidence, risk factors and outcomes(OXFORD UNIV PRESS INC, 2010-05) YILDIZELİ, BEDRETTİN; Ozyurtkan, Mehmet Oguzhan; Yildizeli, Bedrettin; Kuscu, Kemal; Bekiroglu, Nural; Bostanci, Korkut; Batirel, Hasan Fevzi; Yuksel, MustafaObjective: Postoperative psychiatric disorders (PPDs) may complicate the post-surgical outcome. We analysed the types, incidences, risk factors and outcomes of the PPDs in non-cardiac thoracic surgery patients. Methods: All patients (n = 100) undergoing major non-cardiac thoracic surgery from January 2004 to March 2005 were investigated prospectively. The diagnosis of PPD was made based on the Diagnosis and Statistical Manual of Mental Disorders. The patients were grouped into two according to the presence (group I) or absence (group II) of PPD. Data on pre-, per- and postoperative factors, and the adverse outcomes were analysed. Results: Eighteen patients (18%) developed PPD, including delirium in 44%, adjustment disorders in 22%, panic attack in 17%, minor depression in 11% and psychosis in 6%. The patients who developed PPD were older (58 +/- 17 vs 50 +/- 15 years, p = 0.05), had a longer operation time (6 +/- 1 vs 5 +/- 2 h, p = 0.015) and hospital stay (13 +/- 9 vs 8 +/- 5 days, p = 0.019). The morbidity and mortality rates were not significantly different between the groups (67% vs 46%; 11% vs 1%, respectively). The causative factors in the development of PPD were older age, longer operation time, abnormal serum chemistry values of sodium, potassium, calcium and glucose, hypoalbuminaemia, the presence of the postoperative respiratory distress and infection and blood transfusion (p < 0.05). Conclusions: PPDs are associated with adverse outcomes including a longer hospital stay, and increased morbidity and mortality rates. The identification, detection and elimination of these risk factors are recommended. (C) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.Publication Open Access Gestational diabetes screening refusal in pregnant women: a cross-sectional survey study(2022-10-01) BEKİROĞLU, GÜLNAZ NURAL; Usal Tarhan N., Ayvacı Taşan H., Çakar E., Bekiroğlu G. N.Objective: Recently, some pregnant women in Türkiye are hesitant to undergo gestational diabetes mellitus (GDM) screening tests and this trend is more common. The objective of the study is to assess the pregnant women’s knowledges, decisions, reasons for hesitations about having the GDM screening tests and test rejection rates. Material and Methods: This cross-sectional study included 647 pregnant women who applied for an antenatal outpatient clinic and who had not yet been diagnosed with GDM and a survey was conducted using questionnaire designed by the authors. Results: At the beginning, 287 (44.4%) of the participants declared that they would have glucose challenge test, 169 (26.1%) would not and 191 (29.5%) were undecided. The rejection rate was lower in those who had knowledge about the screening tests. After a short information about the content of tests, 30% of the women who decided not to have the test and 78.3% of those who were undecided at the beginning, decided to have the test (p=0.001). Conclusion: The knowledge level of pregnant women about diabetes screening and diagnosis influences their decision-making. Organizing well-planned trainings for patients and healthcare professionals using public institutions and media may be effective in reducing the burden of diabetes on social health and the economic indicators.Publication Open Access Neutrophil/Lymphocyte Ratio Can Predict Postoperative Mortality in Patients with Chronic Thromboembolic Pulmonary Hypertension(MEDICAL TRIBUNE INC, 2015) YILDIZELİ, BEDRETTİN; Yanartas, Mehmed; Kalkan, Mehmet Emin; Arslan, Akin; Tas, Serpil Gezer; Koksal, Cengiz; Bekiroglu, Nural; Yildizeli, BedrettinObjective: The aim of our study was to investigate clinical importance of neutrophil/lymphocyte ratio in patients with Chronic thromboembolic pulmonary hypertension. Methods: 125 consecutive patients with a diagnosis of Chronic thromboembolic pulmonary hypertension were operated pulmonary thromboendarterectomy in our center between February 2011 and August 2013. 106 patients included into the study due to limitations. The patients were classified into two groups as patients discharged alive (Group 1) and those dying in the hospital (Group 2). Baseline neutrophil/lymphocyte ratio level was measured by dividing neutrophil count to lymphocyte count. Results: 84 patients (79%) were in Group 1, 22 patients (21%) were in Group 2. Patients with higher neutrophil/lymphocyte ratio in admission have a significantly higher mortality rate and postoperative pulmonary vascular resistance was found statistically significant variable to predict the mortality. Receiver operator characteristic (ROC) analysis revealed that using a cut-off point of 2.54, admission neutrophil/lymphocyte ratio predicts mortality. Also, correlation analysis showed a significant correlation between preoperative pulmonary vascular resistance and neutrophil/lymphocyte ratio. Conclusion: The neutrophil/lymphocyte ratio level may be a useful and noninvasive biomarker for operative risk stratification for mortality after pulmonary thromboendarterectomy.Publication Open Access Morphometric analysis of middle and posterior cranial fossae foramina in 3d reconstructions of ct images: A midline asymmetry evaluation(2022-01-01) VERİMLİ, URAL; BUĞDAYCI, ONUR; BEKİROĞLU, GÜLNAZ NURAL; VERİMLİ U., BUĞDAYCI O., Yildiz S. D., Ozkilic E., BEKİROĞLU G. N., ÖZDOĞMUŞ N. Ö.Objective: The cranial base harbours numerous foramina, and the anatomical properties of the foramina are crucial in clinical interventions. The purpose of the current study is to evaluate possible asymmetries regarding the middle and posterior cranial fossae foramina using 3D reconstructions of high-resolution computed tomography (CT) images. Patients and Methods: High-resolution cranial CT images of 253 female and 287 male adult patients were used in the study. The patients were 18 to 40 years of age without any apparent cranial pathology. The distances from the foramen rotundum, foramen ovale, foramen spinosum, internal acoustic meatus, hypoglossal canal to the midline were measured bilaterally to compare both sides. Results: The foramen spinosum and the mid-clival line measurements demonstrated statistically significant results favoring the right side (p=0.03, right mean 3.052 ± 0.253 cm, left mean 2.982 ± 0.193 cm). In males, the right foramen spinosum to mid-clival line measurements were significantly longer than the left side (p=0.027, right mean 3.150 ± 0.250 cm, left mean 3.070 ± 0.180 cm). Conclusion: As predicted, the male measurements were significantly longer than the female measurements regardless of sides in all measurements. The measurements of cranial asymmetries may help describe anomalies and may contribute to the clinical approachesPublication Open Access Investigating the Level of Knowledge of the Community about Oral and Dental Health(2021-02) BEKİROĞLU, GÜLNAZ NURAL; Birant, Sinem; Koruyucu, Mine; Ozcan, Hazal; Ilisulu, Ceren; Kasimoglu, Yelda; Ustun, Nilufer; Kocaaydin, Simin; Bektas, Dilara; Usta, Gulsevim; Akay Tekin, Cansu; Bekiroglu, Nural; Seymen, FigenAbstract Objectives This study aimed to determine the knowledge and approaches of the participants about oral and dental health. Materials and Methods This was a questionnaire-based cross-sectional survey. Participants’ demographic characteristics, tooth brushing habits, selection of toothpaste, and reasons for visiting the dentist were examined in this study. Participants’ knowledge levels of fluoride and their attitudes toward the most common fluoride applications among preventive treatments were also evaluated. Data entry and analyses were performed using SPSS statistical software. Descriptive and inferential statistics and chi-square test were used for analyzes. Results A total of 2,744 voluntary participants including 1,938 (70.6%) females and 806 (29.4%) males responded; 1,391 (50.7%) participants know the contents of their toothpaste; 1,680 (61.2%) participants point out that fluoride is effective in preventing dental caries. Female participants reported a statistically significant difference in their knowledge of what is fluoride when compared with male participants (p = 0.0001). The knowledge level of participants who had higher levels of education were statistically significantly different when compared with the participants who had lower education levels about fluoride and fluoride applications (p = 0.0001). Conclusions The results of this study indicate that participants’ attitudes toward oral health and dental care need to be improved.Publication Open Access Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects(AMER PHYSIOLOGICAL SOC, 2009-03) HAKLAR, GONCAGÜL; Enc, Feruze Yilmaz; Oenes, Tunc; Akin, H. Levent; Dede, Fuat; Turoglu, H. Turgut; Uelfer, Goerzde; Bekiroglu, Nural; Haklar, Goncaguel; Rehfeld, Jens F.; Holst, Jens J.; Ulusoy, Nefise B.; Imeryuez, NeseEnc, FY, Ones,T, Akin HL, Dede F, Turoglu HT, Ulfer G, Bekiroglu N, Haklar G, Rehfeld JF, Holst JJ, Ulusoy NB, Imeryuz N. Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects. Am J Physiol Gastrointest Liver Physiol 296: G482-G489, 2009. First published December 24, 2008; doi:10.1152/ajpgi.90209.2008.-Orlistat, an inhibitor of digestive lipases, is widely used for the treatment of obesity. Previous reports on the effect of orally ingested orlistat together with a meal on gastric emptying and secretion of gut peptides that modulate postprandial responses are controversial. We investigated the effect of ingested orlistat on gastric emptying and plasma responses of gut peptides in response to a solid mixed meal with a moderate energy load. In healthy subjects, gastric emptying was determined using scintigraphy and studies were performed without and with 120 mg of orlistat in pellet form in random order. Orlistat shortened t lag and t half and decreased the area under the gastric emptying curve. Orlistat significantly attenuated the secretion of glucose-dependent insulinotropic polypeptide (GIP) but did not alter the plasma responses of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP), and insulin. There was no peptide YY (PYY) response. Area under the curve of gastric emptying was positively correlated with integrated secretion of GIP (r = 0.786) in orlistat and was negatively correlated with integrated plasma response of GLP-1 (r = -0.75) in control experiments, implying that inhibition of fat absorption modifies determinants of gastric emptying of a meal. Orlistat administered similar to its use in obesity treatment accelerates gastric emptying of a solid mixed meal with a moderate energy load and profoundly attenuates release of GIP without appreciably altering plasma responses of CCK, GLP-1, and PP. Since GIP is being implemented in the development of obesity, its role in weight control attained by orlistat awaits further investigation.Publication Open Access Risk of cataract after exposure to low doses of ionizing radiation: A 20-year prospective cohort study among US radiologic technologists(OXFORD UNIV PRESS INC, 2008-07-15) BEKİROĞLU, GÜLNAZ NURAL; Chodick, Gabriel; Bekiroglu, Nural; Hauptmann, Michael; Alexander, Bruce H.; Freedman, D. Michal; Doody, Michele Morin; Cheung, Li C.; Simon, Steven L.; Weinstock, Robert M.; Bouville, Andre; Sigurdson, Alice J.The study aim was to determine the risk of cataract among radiologic technologists with respect to occupational and nonoccupational exposures to ionizing radiation and to personal characteristics. A prospective cohort of 35,705 cataract-free US radiologic technologists aged 24-44 years was followed for nearly 20 years (1983-2004) by using two follow-up questionnaires. During the study period, 2,382 cataracts and 647 cataract extractions were reported. Cigarette smoking for >= 5 pack-years; body mass index of >= 25 kg/m(2); and history of diabetes, hypertension, hypercholesterolemia, or arthritis at baseline were significantly (p <= 0.05) associated with increased risk of cataract. In multivariate models, self-report of >= 3 x-rays to the face/neck was associated with a hazard ratio of cataract of 1.25 (95% confidence interval: 1.06, 1.47). For workers in the highest category (mean, 60 mGy) versus lowest category (mean, 5 mGy) of occupational dose to the lens of the eye, the adjusted hazard ratio of cataract was 1.18 (95% confidence interval: 0.99, 1.40). Findings challenge the National Council on Radiation Protection and International Commission on Radiological Protection assumptions that the lowest cumulative ionizing radiation dose to the lens of the eye that can produce a progressive cataract is approximately 2 Gy, and they support the hypothesis that the lowest cataractogenic dose in humans is substantially less than previously thought.
- «
- 1 (current)
- 2
- 3
- »