Person:
ŞEN, ALİ

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

ŞEN

First Name

ALİ

Name

Filters

2019 - 20203
Reset filters

Settings

Author: DOĞAN, AHMET × Has files: false ×

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    PublicationMetadata only
    Chemical composition of endemic Stachys subnuda Montbret & Aucher ex Benth. essential oil and its anti-inflammatory and antioxidant activities
    (TAYLOR & FRANCIS INC, 2019) DOĞAN, AHMET; Sen, Ali; Kurkcuoglu, Mine; Bitis, Leyla; Dogan, Ahmet; Baser, Kemal Husnu Can
    The essential oil of aerial parts of Stachys subnuda Montbret & Aucher ex Benth (S. subnuda) was analyzed by gas chromatography (GC) and GC/mass spectrometry (MS). Anti-inflammatory activity was evaluated by lipoxygenase inhibition assay. The antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid (ABTS) assays. Sixty-two constituents, comprising 97.1% of the total essential oil composition, were identified. Phytol (25.2%), beta-caryophyllene (11.2%), germacrene D (6.9%), and hexadecanoic acid (6.9%) were the major compounds of aerial part essential oils of S. subnuda. The essential oil showed significant radical scavenging activity with 50% inhibition (IC50) values of 0.124 and 0.204 mg/mL for ABTS and DPPH radicals, respectively. The essential oil exhibited moderate anti-inflammatory activity with an IC50 value of 0.419 mg/mL. The results indicated that S. subnuda essential oil had good anti-inflammatory and antioxidant activity. Also, this is first study on chemical composition, anti-inflammatory and antioxidant activity of S. subnuda essential oil.
  • No Thumbnail Available
    PublicationMetadata only
    Essential oil composition of different parts of Tanacetum cilicicum (Boiss.) Grierson
    (Badebio Biotechnololgy Ltd, 2020) DOĞAN, AHMET; Şen A., Kürkçüoğlu M., Bitiş L., Doğan A., Başer K.H.C.
    The aim of this study was to investigate and compare the chemical composition of essential oils obtained by Clevenger-type apparatus from capitula (TCC) and aerial parts including leaves and stems (TCA) of Tanacetum cilicicum (Boiss.) Grierson from Turkey. TCC and TCA essential oils were separately analysed by GC-FID and GC/MS. Forty and thirty-two compounds were identified, representing 99% and 94.4% of the oils of TCC and TCA essential oils, respectively. The main constituents of the oil of the TCC were camphor (28.8%), (E)-nerolidol (16.9%), trans-chrysanthenyl acetate (12.8%) and 1,8-cineole (8.9%), whereas the oil from TCA comprised mainly trans-chrysanthenyl acetate (22.2%), borneol (19.4%), camphor (11.2%), 1,8-cineole (10.2%) and (E)-nerolidol (9.2%). The results showed that TCC and TCA essential oils were rich in oxygenated monoterpenes and oxygenated sesquiterpenes. This study is the first to study the essential oil composition of different parts of Tanacetum cilicicum separately. Also, to the our best of our knowledge, (E)-nerolidol was found in the Tanacetum species as the major compound for the first time. © 2020, Badebio Biotechnololgy Ltd. All rights reserved.
  • No Thumbnail Available
    PublicationMetadata only
    Chemical composition and biological activities of endemicTripleurospermum conoclinium(Boiss. & Balansa) Hayek essential oils
    (WILEY, 2020) DOĞAN, AHMET; Servi, Huseyin; Sen, Ali; Dogan, Ahmet
    The volatile oils of flowers (TFE), leaves (TLE) and stems (TSE) ofTripleurospermum conoclinium(Boiss. & Balansa) Hayek were obtained by hydrodistillation method for 3 hours with Clevenger-type apparatus. Chemical composition of oils was determined by GC-MS analyses. Antidiabetic, anti-inflammatory and antioxidant activities of oils were tested by alpha-glucosidase inhibitory, 5-lipoxygenase inhibitory and DPPH/ABTS radical scavenging methods, respectively. Eighty-five constituents were identified in flower oil (78.3%). The major compounds of flower oil were artemisia ketone (10.5%), beta-oplopenone (6.0%), tricosane (4.5%), terpinen-4-ol (3.7%) and artemisia alcohol (3.5%). Sixty-two constituents were identified in leaf oil (67.0%). 1-octadecanol (11.5%), caryophyllene oxide (5.7%), elemol (3.9%), phytol (3.5%), ledene oxide (3.3%) and artemisia ketone (3.1%) were found as main constituents in the leaf oil. Forty-six constituents were determined in the stem oil (75.1%). The main compounds of the stem oil were 1-octadecanol (11.1%), beta-oplopenone (5.5%), ledene oxide (5.5%), caryophyllene oxide (4.4%) and phytol (3.0%). TLE and TSE displayed strong antidiabetic activity with IC(50)values of 21.30 and 29.57 mu g/mL against alpha-glucosidase enzyme, respectively. TLE showed the best anti-inflammatory activity with an IC(50)value of 91.02 mu g/mL while TFE and TSE exhibited moderate activity with IC(50)values of 186.50 and 257.10 mu g/mL, respectively. TFE and TLE were found to possess moderate antioxidant activity with IC(50)values of 572.80 and 385.80 mu g/mL against ABTS radical while all essential oils showed weak activity against DPPH radical. To the best of our knowledge, this is first report on chemical composition and biological activities ofTconocliniumessential oils.