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BİTİŞ, LEYLA

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Author: DOĞAN, AHMET × Has files: false ×

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    Chemical composition of endemic Stachys subnuda Montbret & Aucher ex Benth. essential oil and its anti-inflammatory and antioxidant activities
    (TAYLOR & FRANCIS INC, 2019) DOĞAN, AHMET; Sen, Ali; Kurkcuoglu, Mine; Bitis, Leyla; Dogan, Ahmet; Baser, Kemal Husnu Can
    The essential oil of aerial parts of Stachys subnuda Montbret & Aucher ex Benth (S. subnuda) was analyzed by gas chromatography (GC) and GC/mass spectrometry (MS). Anti-inflammatory activity was evaluated by lipoxygenase inhibition assay. The antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid (ABTS) assays. Sixty-two constituents, comprising 97.1% of the total essential oil composition, were identified. Phytol (25.2%), beta-caryophyllene (11.2%), germacrene D (6.9%), and hexadecanoic acid (6.9%) were the major compounds of aerial part essential oils of S. subnuda. The essential oil showed significant radical scavenging activity with 50% inhibition (IC50) values of 0.124 and 0.204 mg/mL for ABTS and DPPH radicals, respectively. The essential oil exhibited moderate anti-inflammatory activity with an IC50 value of 0.419 mg/mL. The results indicated that S. subnuda essential oil had good anti-inflammatory and antioxidant activity. Also, this is first study on chemical composition, anti-inflammatory and antioxidant activity of S. subnuda essential oil.
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    Essential oil composition of different parts of Tanacetum cilicicum (Boiss.) Grierson
    (Badebio Biotechnololgy Ltd, 2020) DOĞAN, AHMET; Şen A., Kürkçüoğlu M., Bitiş L., Doğan A., Başer K.H.C.
    The aim of this study was to investigate and compare the chemical composition of essential oils obtained by Clevenger-type apparatus from capitula (TCC) and aerial parts including leaves and stems (TCA) of Tanacetum cilicicum (Boiss.) Grierson from Turkey. TCC and TCA essential oils were separately analysed by GC-FID and GC/MS. Forty and thirty-two compounds were identified, representing 99% and 94.4% of the oils of TCC and TCA essential oils, respectively. The main constituents of the oil of the TCC were camphor (28.8%), (E)-nerolidol (16.9%), trans-chrysanthenyl acetate (12.8%) and 1,8-cineole (8.9%), whereas the oil from TCA comprised mainly trans-chrysanthenyl acetate (22.2%), borneol (19.4%), camphor (11.2%), 1,8-cineole (10.2%) and (E)-nerolidol (9.2%). The results showed that TCC and TCA essential oils were rich in oxygenated monoterpenes and oxygenated sesquiterpenes. This study is the first to study the essential oil composition of different parts of Tanacetum cilicicum separately. Also, to the our best of our knowledge, (E)-nerolidol was found in the Tanacetum species as the major compound for the first time. © 2020, Badebio Biotechnololgy Ltd. All rights reserved.