Person: ERMERAK, NEZİH ONUR
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ERMERAK
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NEZİH ONUR
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Publication Open Access The angiogenic gene profile of pulmonary endarterectomy specimens: Initial study(2023-01-01) ERMERAK, NEZİH ONUR; YILMAZ, BETÜL; BATIREL, SAİME; OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; MUTLU, BÜLENT; YILDIZELİ, BEDRETTİN; ERMERAK N. O., YILMAZ B., BATIREL S., OLGUN YILDIZELİ Ş., KOCAKAYA D., MUTLU B., Tas S., YILDIZELİ B.© 2023 The Author(s)Objectives: The underlying mechanisms for the development of chronic thromboembolic pulmonary hypertension and prognostic biomarkers are not clear yet. Thus, our aim is to assess and identify new biomarkers for the expression of 84 key genes linked to angiogenesis. Methods: Patients who had levels more than 1000 dynes·sec·cm−5 were included in the test group, and the other patients were included in the control group. Twelve specimens were taken from the patients. RT2 Profiler PCR Array (Qiagen) was used to quantify the expression of the 84 key genes. Results: Eight patients (6 male, 2 female, median age 54.4 ± 13.1 years) who underwent pulmonary endarterectomy were included. Pulmonary vascular resistance improved significantly from 811 ± 390 dyn/s/cm−5 to 413.3 ± 144.9 dyn/s/cm−5 (P .005) after surgery. Median length of hospital stay was 11.62 ± 2.97 days. The test group had a distinct pattern of impaired angiogenic and antiangiogenic genes. The expression levels of TGFA, TGFB1, THBS2, THBS1, TGFBR1, SERPINE1, SERPINF1, TGFB2, TIMP2, VEGFC, IFNA1, TNF, CXCL10, NOS3, IGF1, and MMP14 were downregulated in the specimens from the patients who had higher pulmonary vascular resistance values, whereas some genes, including PDGFA, showed upregulation that was statistically nonsignificant in the same group. Conclusions: These results can lead to the development of new markers that could predict adverse outcomes of patients with CTEPH. Identification of new markers that are related to worse outcomes would enable screening patients for early diagnosis and treatment.Publication Metadata only Trombin jenerasyon zamanı ve endotel disfonsiyon belirteçlerinin pulmoner endarterektomi sonuçlarına etkisi(2023-10-19) ERMERAK, NEZİH ONUR; LAÇİN, TUNÇ; TOPTAŞ, TAYFUR; OLGUN YILDIZELİ, ŞEHNAZ; AK, KORAY; YILDIZELİ, BEDRETTİN; TİRYAKİ G. G., Ertan R., Pasayev J., ERMERAK N. O., LAÇİN T., TOPTAŞ T., OLGUN YILDIZELİ Ş., Taş H., AK K., YILDIZELİ B.Publication Metadata only Does tapse/spap ratio predict early outcome followingpulmonary endarterectomy(2023-06-04) OLGUN YILDIZELİ, ŞEHNAZ; ERMERAK, NEZİH ONUR; MUTLU, BÜLENT; KOCAKAYA, DERYA; AK, KORAY; BEKİROĞLU, GÜLNAZ NURAL; YILDIZELİ, BEDRETTİN; TİRYAKİ G. G., Ertan R., OLGUN YILDIZELİ Ş., ERMERAK N. O., MUTLU B., KOCAKAYA D., TAŞ S., AK K., BEKİROĞLU G. N., YILDIZELİ B.Publication Metadata only Malignite şüphesi ile tanı alan bir pulmoner amiloidosiz vakası(2018-04-11) KOCAKAYA, DERYA; ERMERAK, NEZİH ONUR; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; AHISKALI, ASİYE RENGİN; KOCAKAYA D., ERMERAK N. O., ERÇETİN S. Y., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E., AHISKALI A. R.Publication Metadata only Covid sonrası gelişen diğer bir uzun dönem komplikasyon ve cerrahi tedavisi: Post-Covid KTEPH(2022-11-05) ERMERAK, NEZİH ONUR; OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; MUTLU, BÜLENT; AK, KORAY; YILDIZELİ, BEDRETTİN; ERMERAK N. O., OLGUN YILDIZELİ Ş., KOCAKAYA D., TİRYAKİ G. G., Güçtekin Y., MUTLU B., AK K., TAŞ S., YILDIZELİ B.Publication Metadata only Pulmoner nodül rezeksiyonu yapılan olgularda klinik radyolojik bulguların malign histopatolojik tanılar ile korelasyonu(2023-05-09) OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; ERMERAK, NEZİH ONUR; BOZKURTLAR, EMİNE; ERYÜKSEL, SEMİHA EMEL; ÇİMŞİT, NURİ ÇAGATAY; YILDIZELİ, BEDRETTİN; KARAKURT, SAİT; OLGUN YILDIZELİ Ş., GİVİVİ S., KOCAKAYA D., ERMERAK N. O., BOZKURTLAR E., ERYÜKSEL S. E., ÇİMŞİT N. Ç., YILDIZELİ B., KARAKURT S.Pulmonary nodules are common (nc(dental f(nd(ng on thorac(c computed tomography (CT) and st(ll a problem (n da(ly pulmonary pract(ce. Because of the w(dely usage of CT scans an (ncreased number of pat(ents follow up w(th th(s d(agnose. Nodules may or(g(nated secondary to ben(gn d(seases but pr(mary concern (s mal(gnanc(es wh(ch (s (mportant for early d(agnos(s and curat(ve opt(ons. On the other hand (t (s not cost-effect(ve follow(ng up the ben(gn les(ons w(th an add(t(onal cumulat(ve rad(at(on dose espec(ally (n prolonged durat(on. Many pred(ct(on models were proposed to evaluate the potency of mal(gnancy us(ng cl(n(cal and rad(olog(cal f(nd(ngs Mayo cl(n(c (1), Veterans Assoc(at(on (2), Brock Un(vers(ty (3) and lastly Herder model (4) mostly used models for r(sk strat(f(cat(on. Herder r(sk model evaluates also Flour(ne– flourodeoxyglucose (FDG) uptake (n pos(tron em(ss(on tomography-computed tomography (PET-CT). Comparat(ve study of these models showed non-super(or(ty to each other, added value of PET-CT (s unden(able for larger nodules but not clear for small nodules (< 8mm) (5). Mult(d(sc(pl(nary follow up, careful observat(on and d(agnost(c test(ng are st(ll h(ghly recommended espec(ally for (ndeterm(ne nodulesPublication Metadata only Bronchoscopic lung volume reduction with coils for end-stage chronic obstructive pulmonary disease: a single institutionexperience(2015-05-31) BOSTANCI, KORKUT; OLGUN YILDIZELİ, ŞEHNAZ; ERMERAK, NEZİH ONUR; ERYÜKSEL, SEMİHA EMEL; BOSTANCI K., BİLGİ Z., ÖMERCİKOĞLU H., OLGUN YILDIZELİ Ş., ÇETİNKAYA Ç., ERMERAK N. O., ERYÜKSEL S. E., YÜKSEL M.