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DOĞAN, BAŞAK

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Author: YILDIRIM, HATİCE SELİN ×

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    Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner-masked, randomized, controlled clinical trial
    (AMER ACAD PERIODONTOLOGY, 2018) DOĞAN, BAŞAK; Yildirim, Selin; Ozener, Hafize Ozturk; Dogan, Basak; Kuru, Bahar
    Background: This study aims to evaluate the effects of two different concentrations of topical hyaluronic acid (HA) on postoperative patient discomfort and wound healing of palatal donor sites after free gingival graft (FGG) surgery. Methods: Thirty-six patients requiring FGG were randomly assigned into three groups in an examiner-masked, randomized, controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% HA gels were used in test groups 1 and 2, respectively. Gels were applied on donor sites and protected with periodontal dressing in the test groups, whereas the wound was covered only with periodontal dressing in the control group. On days 3, 7, 14, and 21, pain and burning sensation were recorded using a visual analog scale (VAS) as well as other parameters such as complete epithelization (CE) and color match on days 3, 7, 14, 21, and 42. Results: Test groups experienced less pain than the control group on days 3 and 7 (P < 0.001 and P < 0.001, respectively). Mean VAS score for burning sensation was higher in the control group on day 3 compared with test groups 1 and 2 (P = 0.03 and P = 0.02, respectively). CE in all patients was achieved on day 21 in both test groups, whereas it was achieved on day 42 in the control group. The test groups showed higher color match scores than the control group on days 21 (P < 0.001 and P < 0.001, respectively) and 42 (P = 0.004 and P = 0.002, respectively). Conclusion: Topical application of HA exhibits positive impact on postoperative pain and burning sensation, and accelerates palatal wound healing in terms of epithelization and color match.
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    Effect of non-surgical periodontal treatmenton salivary IL-13 levels in periodontitis with andwithout type 2 diabetes
    (2022-06-10) YILDIRIM, HATİCE SELİN; İYİGÜN, SEZGİ; DOĞAN, BAŞAK; YILDIRIM H. S., KALKAN Y., İYİGÜN S., DOĞAN B.
    Background & Aim: Interleukin (IL)-13 is an anti-inflammatory and fibrogenic cytokine activated by T helper 2 cells. It has been shown that IL-13 inhibits pro-inflammatory cytokine synthesis and osteoclastogenesis. The aim of the study was to determine the effect of non-surgical periodontal treatment (NSPT) on salivary IL-13 levels in periodontitis patients with and without type 2 diabetes mellitus (T2DM). Methods: A total of 48 subjects, 12 systemically and periodontally healthy (H), 12 periodontitis with well controlled T2DM, 12 periodontitis with poorly controlled T2DM and 12 systemically healthy periodontitis, were recruited for the study. All periodontitis patients belonged to either Stage III or IV periodontitis. At baseline, all clinical parameters including plaque index, gingival index, bleeding on probing, probing depth and clinical attachment loss were recorded, and the saliva samples were collected from all subjects, at 3 months following the NSPT only from periodontitis groups. Salivary IL-13 levels were analysed by enzyme-linked immunosorbent assay. This study was supported by the grant from Marmara University Scientific Research Projects Coordination Unit #SAG-A-080519-0172. Results: All clinical parameters were higher in all periodontitis groups than the healthy subjects at baseline (p < 0.05) and improved 3 months after NSPT in all periodontitis groups (p < 0.05). At baseline, salivary IL-13 levels were lower in all periodontitis groups compared to H group (p < 0.05) but were similar among 3 periodontitis groups (p > 0.05). At 3 months following NSPT IL-13 levels were increased in all 3 periodontitis groups compared to baseline (p < 0.05). Conclusions: This study has revealed that low levels of salivary IL-13 are associated with periodontitis not T2DM. IL-13 may be used as a biomarker for both the diagnosis and treatment of periodontitis.