Person: DOĞAN, BAŞAK
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
DOĞAN
First Name
BAŞAK
Name
8 results
Search Results
Now showing 1 - 8 of 8
Publication Metadata only Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner-masked, randomized, controlled clinical trial(AMER ACAD PERIODONTOLOGY, 2018) DOĞAN, BAŞAK; Yildirim, Selin; Ozener, Hafize Ozturk; Dogan, Basak; Kuru, BaharBackground: This study aims to evaluate the effects of two different concentrations of topical hyaluronic acid (HA) on postoperative patient discomfort and wound healing of palatal donor sites after free gingival graft (FGG) surgery. Methods: Thirty-six patients requiring FGG were randomly assigned into three groups in an examiner-masked, randomized, controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% HA gels were used in test groups 1 and 2, respectively. Gels were applied on donor sites and protected with periodontal dressing in the test groups, whereas the wound was covered only with periodontal dressing in the control group. On days 3, 7, 14, and 21, pain and burning sensation were recorded using a visual analog scale (VAS) as well as other parameters such as complete epithelization (CE) and color match on days 3, 7, 14, 21, and 42. Results: Test groups experienced less pain than the control group on days 3 and 7 (P < 0.001 and P < 0.001, respectively). Mean VAS score for burning sensation was higher in the control group on day 3 compared with test groups 1 and 2 (P = 0.03 and P = 0.02, respectively). CE in all patients was achieved on day 21 in both test groups, whereas it was achieved on day 42 in the control group. The test groups showed higher color match scores than the control group on days 21 (P < 0.001 and P < 0.001, respectively) and 42 (P = 0.004 and P = 0.002, respectively). Conclusion: Topical application of HA exhibits positive impact on postoperative pain and burning sensation, and accelerates palatal wound healing in terms of epithelization and color match.Publication Open Access Microbial composition and non-surgical periodontal treatment of aggressive periodontitis: Two case reports(2019) DOĞAN, BAŞAK; Dilek MAMAKLIOĞLU;Bahar EREN KURU;Maribasappa KARCHED;BAŞAK DOĞANThe objective of this case report was to characterize the subgingival microbiological profiles of two patients with generalized aggressive periodontitis (GAgP) and to evaluatethe clinical outcomes of non-surgical periodontal treatment(NSPT) over a 6-months period. Pooled subgingival samplesof two patients who referred to our clinic and diagnosed withGAgP were collected and analyzed for the presence of 300species/phlotypes using Human Oral Microbe IdentificationMicroarray analysis. NSPT was performed within 3-week period. Clinical parameters were measured at baseline, 3 and6 months after NSPT. Recall visits were performed every 2weeks during the first 3 months and every 4 weeks up to 6months. All samples harboured a total of 61 species and 32species were common in both patients. First patient had 17and the other had 12 distinct species. High levels of Filifactor alocis, Porpyromonas gingivalis, Campylobacter concisusand rectus, Fusobacterium nucleatum and Desulfobulbusspp. were detected in both patients while Aggregatibacter actinomycetemcomitans was found in none of them. Six monthsafter NSPT, all clinical parameters were improved in two A. actinomycetemcomitans-negative GAgP patients. In addition towell-recognized periodontal pathogens the presence of highlevels of Filifactor alocis and Desulfobulbus spp. seem to beassociated with GAgP.Publication Open Access Multidisciplinary Treatment Approach in a Patient with History of Nasopharyngeal Carcinoma(2014) DOĞAN, BAŞAK; Yavuz, Atacan; Ağralı, Omer Birkan; Calışkan, Zeynep Lale; Türkaydın, Dilek; Sertgöz, Atilla; Kuru, Bahar; Doğan, BaşakRadiotherapy in NPC patients has side effects on the dentition, which affects quality of life dramatically. This case report presents multidisciplinary dental treatment approach in a 17-year-old male patient with a history of nasopharyngeal carcinoma (NPC), which was treated with chemotherapy and radiotherapy. The adolescent patient applied to dental hospital 4 years after the radiotherapy with aesthetic and functional problems on dentition affecting psychological, social, and physical aspects of his life. The dentition of the patient demonstrated the severe destruction as a devastating side effect of radiotherapy. With a successful multidisciplinary approach, our patient's aesthetics, function, and self-confidence were obtained. Well-established procedures, which include preventative care and maintenance, can reduce the duration and expenses of the treatment and help in challenging the life-long complications of radiotherapy.Publication Open Access Different treatment approaches for the localized gingival overgrowths: Case series(2018-04) DOĞAN, BAŞAK; Ozener, Hafize Ozturk; Kundak, Kubra; Sipahi, Nimet Gul; Yetis, Ece; Dogan, BasakABSTRACT Localized gingival overgrowths belong to a common group of lesions designated as focal reactive overgrowths. They occur in response to chronic, low‑grade irritation caused by plaque or any other irritant. They have multifactorial etiopathology but exhibit similar clinical features with slight variations in patient complaints. Success of the lesions’ management depends on formation of healthy contours of the surgical area after excision of lesion and absence of a recurrence. The purpose of case series is to present 6 different cases of localized gingival overgrowths and their management with the following techniques: nonsurgical periodontal treatment, gingivectomy, flap surgery, free gingival graft, gingival unit, and connective tissue graft.Publication Open Access Specified Species in Gingival Crevicular Fluid Predict Bacterial Diversity(PUBLIC LIBRARY SCIENCE, 2010-10-25) DOĞAN, BAŞAK; Asikainen, Sirkka; Dogan, Basak; Turgut, Zeynep; Paster, Bruce J.; Bodur, Aysen; Oscarsson, JanBackground: Analysis of gingival crevicular fluid (GCF) samples may give information of unattached (planktonic) subgingival bacteria. Our study represents the first one targeting the identity of bacteria in GCF. Methodology/Principal Findings: We determined bacterial species diversity in GCF samples of a group of periodontitis patients and delineated contributing bacterial and host-associated factors. Subgingival paper point (PP) samples from the same sites were taken for comparison. After DNA extraction, 16S rRNA genes were PCR amplified and DNA-DNA hybridization was performed using a microarray for over 300 bacterial species or groups. Altogether 133 species from 41 genera and 8 phyla were detected with 9 to 62 and 18 to 64 species in GCF and PP samples, respectively, per patient. Projection to latent structures by means of partial least squares (PLS) was applied to the multivariate data analysis. PLS regression analysis showed that species of genera including Campylobacter, Selenomonas, Porphyromonas, Catonella, Tannerella, Dialister, Peptostreptococcus, Streptococcus and Eubacterium had significant positive correlations and the number of teeth with low-grade attachment loss a significant negative correlation to species diversity in GCF samples. OPLS/O2PLS discriminant analysis revealed significant positive correlations to GCF sample group membership for species of genera Campylobacter, Leptotrichia, Prevotella, Dialister, Tannerella, Haemophilus, Fusobacterium, Eubacterium, and Actinomyces. Conclusions/Significance: Among a variety of detected species those traditionally classified as Gram-negative anaerobes growing in mature subgingival biofilms were the main predictors for species diversity in GCF samples as well as responsible for distinguishing GCF samples from PP samples. GCF bacteria may provide new prospects for studying dynamic properties of subgingival biofilms.Publication Open Access Occurrence and serotype distribution of Aggregatibacter actinomycetemcomitans in subjects without periodontitis in Turkey(PERGAMON-ELSEVIER SCIENCE LTD, 2016-01) DOĞAN, BAŞAK; Dogan, Basak; Chen, Jason; Ciftlikli, Sinem Yildiz; Huang, Jonathan; Kadir, Tanju; Alniak, Anil Kinaci; Chen, CaseyObjective: To determine the occurrence and serotype distribution of Aggregatibacter actinomycetemcomitans in subjects without periodontitis. Design: Systemically healthy dental students without periodontitis (n = 94), who had not used antibiotics within the last 3 months or received any form of periodontal therapy within the last 6 months, were included in the study. Pooled subgingival microbiological samples were collected from 4 first molars and 4 central incisors in each subject using sterile paper points. All samples were tested for the presence and the serotype of A. actinomycetemcomitans through PCR analysis of the 16S rRNA genes and the serotype-specific gene clusters in the DNA extracted from the samples. Results: Of the 94 samples that were tested, 43 (46%) were positive for A. actinomycetemcomitans. No statistically significant differences in clinical parameters were found between subgingival sites with or without detectable A. actinomycetemcomitans (t-test, P > 0.01). Among the 43 A. actinomycetemcomitans-positive samples, the serotype was identified in 21 samples. Fifteen were positive for A. actinomycetemcomitans serotype a, 1 for serotype b, 1 for serotype c, and 4 for serotype f, while serotypes d and e were not detected. Conclusion: A. actinomycetemcomitans serotype a is the most commonly found serotype among Turkish dental students without periodontitis. (C) 2015 Elsevier Ltd. All rights reserved.Publication Metadata only Lack of Serotype Antigen in A. actinomycetemcomitans(SAGE PUBLICATIONS INC, 2010) DOĞAN, BAŞAK; Kanasi, E.; Dogan, B.; Karched, M.; Thay, B.; Oscarsson, J.; Asikainen, S.Aggregatibacter actinomycetemcomitans is divided into 6 serotypes. Occurrence of non-serotypeable strains is known, but background reasons are unclear. We hypothesized that non-serotypeable strains represent new serotypes or have altered expression of serotype-specific polysaccharide antigen (S-PA). We first characterized 311 strains from 189 individuals using both immunoassay-and PCR-based serotyping. Next, using natural human infection and rabbit immunization approaches, we clarified whether the phenotypically non-serotypeable strains expressed S-PA. Immunoassay identified serotypes a-f among 216 strains from 159 individuals. The remaining 95 strains from 30 individuals were phenotypically non-serotypeable. Yet, all these strains were identified by PCR-typing as serotype a-, b-, c-, or f. Non-serotypeability was confirmed by Western immunoblot with respective rabbit antisera. Patient sera remained non-reactive with autologous non-serotypeable strains at the serotype-specific region. Rabbit immunization with a phenotypically non-serotypeable strain induced no antibody production against S-PA. Thus, phenotypically non-serotypeable strains did not include novel serotypes, but lacked S-PA expression.Publication Metadata only Salivary interleukin-17 and tumor necrosis factor- in relation to periodontitis and glycemic status in type 2 diabetes mellitus(WILEY, 2015) DOĞAN, BAŞAK; Gursoy, Ulvi Kahraman; Yildiz Ciftlikli, Sinem; Kononen, Eija; Gursoy, Mervi; Dogan, BasakBackgroundPoorly-controlled glycemic status in type 2 diabetes mellitus (T2DM) is suggested to play a role in the periodontal inflammatory process by aggregating the local cytokine response. Our objectives were to profile salivary interleukin (IL)-17 and tumor necrosis factor (TNF)- levels in subjects with T2DM and to examine their relevance for the periodontal health status and glycemic control levels. MethodsUnstimulated whole saliva samples, together with full-mouth periodontal recordings (plaque index [PI], bleeding on probing [BOP %], gingival index [GI], probing pocket depth [PPD], and clinical attachment level [CAL]), were collected from 123 subjects with T2DM. Additionally, demographic and general health parameters, including fasting blood glucose, glycated hemoglobin (HbA1c), were collected. Salivary IL-17 and TNF- concentrations were analyzed using the Luminex (R)-xMAP technique. ResultsSubjects with poorly-controlled T2DM (HbA1c7) had elevated serum triglyceride (P<0.001) concentration as well as elevated scores of BOP % (P=0.014), PI (P=0.048), GI (P=0.033), and CAL (P=0.003) in comparison to those of well-controlled T2DM (HbA1c<7). When the subjects with detectable salivary IL-17 were categorized in tertiles, the scores of PPD and BOP%, and salivary TNF- concentrations were significantly elevated in the highest (P=0.007, P=0.002 and P<0.001, respectively) and middle (P=0.052, P=0.022, and P=0.003, respectively) tertiles compared to subjects with non-detectable salivary IL-17. The adjusted association between PPD measurements and salivary IL-17 concentrations was significant (P=0.008). ConclusionsPoorly-controlled glycemic status relates to the severity of periodontal disease in T2DM. The association between PPD and IL-17 in saliva, however, is independent from the effect of glycemic status. ?? ??????????????2????(T2DM)?????????????????????????????????T2DM???????????(IL)-17????????(TNF)-???,?????????????????????????? ???123?T2DM?????????????????????(????[plaque index,PI],?????[bleeding on probing,BOP %],????[gingival index,GI],?????[probing pocket depth,PPD]????????[clinical attachment level,CAL])???,??????????????????,?????????????(HbA1c)???Luminex (R)-xMAP????????IL-17?TNF-??? ??????????T2DM???(HbA1c<7)??,??????T2DM???(HbA1c7)???????????(P<0.001),????BOP %(P=0.014)?PI(P=0.048)?GI(P=0.033)??CAL(P=0.003)?????????????IL-17???????,??????IL-17??????IL-17??????3?,??PPD?BOP %???????TNF-????????(??P=0.007,P=0.002?P<0.001)???(??P=0.052,P=0.022?P=0.003)?????????????PPD????????TNF-?????????(P=0.008)? ??T2DM?????????????????????PPD????IL-17??,??,????????????????