Person: DOĞAN, BAŞAK
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DOĞAN
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BAŞAK
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Publication Metadata only The relationship between vitamin D receptor gene polymorphisms and periodontitis in turkish individuals with type 2 diabetes mellitus(2022-07-01) DOĞAN, BAŞAK; MEGA TİBER, PINAR; Yildiz A. S., Ustundag F. D., Tiber P., Dogan B.© 2022 Wolters Kluwer Medknow Publications. All rights reserved.Background and Aim: Vitamin D receptor (VDR) gene polymorphisms have been implicated in the pathogenesis of many diseases, such as periodontitis and diabetes mellitus (DM). The present study aimed to evaluate the distributions of VDR polymorphisms in diabetic individuals with healthy periodontium (DMH), diabetic individuals with periodontitis (DMP), nondiabetic individuals with healthy periodontium (H), and nondiabetic individuals with periodontitis (P). Material and Methods: A total of 200 individuals (DMH = 40, DMP = 60, H = 40, and P = 60) were recruited. All clinical periodontal parameters, demographical, and biochemical variables were recorded. Blood samples were collected, and genomic DNA was isolated by Purelink® Genomic DNA Mini Kit. Genotyping of VDR polymorphisms ApaI, BsmI, FokI, and TaqI were determined by real-time polymerase chain reaction (PCR) using allele-specific probes. Results: The distribution of the BsmI variant showed differences between DMH and H groups (P = 0.034). In addition, carrying the GG genotype (OR = 0.317; 95% CI = 0.126-0.797; P = 0.013) and the G allele (OR = 2.373; 95% CI = 1.203-4.681; P = 0.012) increased the risk of type 2 DM. Moreover, it was determined that the frequency of CC genotype of FokI variant was higher in DMP compared to DMH (P = 0.046). It was determined that having the CC genotype (OR = 2.706; 95% CI = 1.185-6.176; P = 0.017) and the C allele (OR = 1.917; 95% CI = 0.995-3.694; P = 0.049) increased the risk of periodontitis among diabetic individuals. No differences were detected among groups in the genotype and allele distributions of ApaI and TaqI variants (P > 0.05). Conclusions: The present study showed that the BsmI variant was a risk factor for DM among periodontally healthy individuals and the FokI variant for periodontitis among diabetic individuals.Publication Metadata only Effect of non-surgical periodontal treatmenton salivary IL-13 levels in periodontitis with andwithout type 2 diabetes(2022-06-10) YILDIRIM, HATİCE SELİN; İYİGÜN, SEZGİ; DOĞAN, BAŞAK; YILDIRIM H. S., KALKAN Y., İYİGÜN S., DOĞAN B.Background & Aim: Interleukin (IL)-13 is an anti-inflammatory and fibrogenic cytokine activated by T helper 2 cells. It has been shown that IL-13 inhibits pro-inflammatory cytokine synthesis and osteoclastogenesis. The aim of the study was to determine the effect of non-surgical periodontal treatment (NSPT) on salivary IL-13 levels in periodontitis patients with and without type 2 diabetes mellitus (T2DM). Methods: A total of 48 subjects, 12 systemically and periodontally healthy (H), 12 periodontitis with well controlled T2DM, 12 periodontitis with poorly controlled T2DM and 12 systemically healthy periodontitis, were recruited for the study. All periodontitis patients belonged to either Stage III or IV periodontitis. At baseline, all clinical parameters including plaque index, gingival index, bleeding on probing, probing depth and clinical attachment loss were recorded, and the saliva samples were collected from all subjects, at 3 months following the NSPT only from periodontitis groups. Salivary IL-13 levels were analysed by enzyme-linked immunosorbent assay. This study was supported by the grant from Marmara University Scientific Research Projects Coordination Unit #SAG-A-080519-0172. Results: All clinical parameters were higher in all periodontitis groups than the healthy subjects at baseline (p < 0.05) and improved 3 months after NSPT in all periodontitis groups (p < 0.05). At baseline, salivary IL-13 levels were lower in all periodontitis groups compared to H group (p < 0.05) but were similar among 3 periodontitis groups (p > 0.05). At 3 months following NSPT IL-13 levels were increased in all 3 periodontitis groups compared to baseline (p < 0.05). Conclusions: This study has revealed that low levels of salivary IL-13 are associated with periodontitis not T2DM. IL-13 may be used as a biomarker for both the diagnosis and treatment of periodontitis.Publication Metadata only Yaşlı Bireylerde Cerrahi Olmayan Periodontal Tedavi Yaklaşımı(Türkiye Klinikleri Yayınevi, 2022-12-01) ÖZTÜRK ÖZENER, HAFİZE; AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; Öztürk Özener H., Ağralı Ö. B., Doğan B.Publication Metadata only Yaşlı bireylerde cerrahi olmayan periodontal tedavi yaklaşımı(Türkiye Klinikleri, 2022-01-01) ÖZTÜRK ÖZENER, HAFİZE; AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; ÖZTÜRK H., AĞRALI Ö. B., DOĞAN B.Publication Open Access Effect of non-surgical periodontal therapy on salivary melatonin levels(2022-04-01) YARAT, AYŞEN; DOĞAN, BAŞAK; KURU, LEYLA; KUNDAK K., YARAT A., DOĞAN B., KURU L.Objective: Melatonin, a hormone secreted predominantly by pineal gland in a circadian manner, has antioxidant and anti-inflammatory effects. The current research is conducted to explore the influence of non-surgical periodontal therapy (NSPT) on levels of salivary melatonin in subjects with gingivitis and periodontitis. Methods: Sixty systemically healthy participants were included in this study; the groups are as follows: gingivitis (G), chronic periodontitis (CP), generalized aggressive periodontitis (GAP) and periodontally healthy (H). NSPT was applied to G group patients for 2 sessions, to CP and GAP group patients for 4 sessions. Plaque and gingival indices, probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL) were documented at baseline and 3 months post – treatment and early morning salivary samples were collected. ELISA was used to detect melatonin levels in saliva. Pittsburgh Sleep Quality Index (PSQI) questionnaire was performed to evaluate of sleep quality of patients. Results: At baseline, significant difference in gingival index, PD, BOP and CAL values was detected among all groups (p<0.05). Following NSPT, clinical measurements improved in G, CP, and GAP groups significantly (p<0.05). While salivary melatonin concentration of all groups was similar at baseline (p>0.05), a significant elevation in the level of salivary melatonin was found only in the G group after NSPT (p<0.05). PSQI scores differed significantly among groups (p<0.05). Conclusion: The salivary melatonin levels in the presence of gingivitis and periodontitis varied at baseline and elevated following NSPT parallel to the improvement in clinical parameters.Publication Metadata only Salivary MMP-8, MAF, and IL-34 levels in non-surgical periodontal treatment of gingivitis patients(2022-06-10) DOĞAN, BAŞAK; GÖRGÜLÜ N. G., DOĞAN B.Background and Aim: Specific biomarkers' diagnostic ability for peri-odontitis has been identified and widely studied; however, such stud-ies targeting gingivitis are rather rare. The aim of the study was toevaluate the levels of matrix metalloproteinase (MMP-8), Interleukin(IL)-34, and macrophage activating factor (MAF) in the saliva of peri-odontally healthy and gingivitis participants and to compare thechanges following non-surgical periodontal treatment (NSPT) Methods: A total of 36 subjects, 18 periodontally healthy and 18 gingi-vitis, were recruited to the study. The clinical periodontal parameterswere recorded, and the saliva samples were collected from all subjectsat baseline. Gingivitis patients received NSPT, and all clinical peri-odontal parameters and saliva samples were re-collected at 3 months.MMP-8, MAF, and IL-34 levels were analyzed by using ELISA. Thisstudy was supported by grants from Marmara University ScientificResearch Projects Coordination Unit #SAG-A-230119-0014.Results: All clinical parameters were higher in the gingivitis group thanthe healthy ones at baseline and improved at 3 months after NSPT ingingivitis patients (p< 0.05). Salivary MMP-8 and IL-34 levels weresignificantly higher in gingivitis patients compared to healthy ones atbaseline (p< 0.05). The salivary MMP-8 levels in the gingivitis groupdecreased at 3 months compared to baseline (p=0.008). However,salivary IL-34 levels remained unchanged throughout the study period(p> 0.05). The salivary MAF levels were similar between gingivitis andhealthy groups at baseline (p> 0.05), whereas significantly decreasedat 3 months compared to baseline (p=0.002).Conclusions: The results of this study confirm that salivary MMP-8plays a role as a reliable biological marker in the pathogenesis of gingi-vitis, and NSPT is effective in decreasing its levels. In addition, peri-odontal inflammation was found to alter salivary IL-34 levels ingingivitis patientsPublication Metadata only Effect of non-surgical periodontal treatment serum sirt-1 sevivelerine etkisi on salivary and serum sirt-I levels(2022-11-09) DOĞAN, BAŞAK; İYİGÜN S., GÖRGÜLÜ N. G., DOĞAN B.Publication Metadata only Salivary and serum markers of angiogenesis in periodontitis in relation to smoking(SPRINGER HEIDELBERG, 2021) DOĞAN, BAŞAK; Yilmaz Sastim, Cigdem; Gursoy, Mervi; Kononen, Eija; Kasurinen, Akseli; Norvio, Susanna; Gursoy, Ulvi Kahraman; Dogan, BasakObjective Angiogenesis is essential in maintenance of periodontal homeostasis, and it is regulated by growth factors and cytokines, including basic fibroblast growth factor (b-FGF), endoglin, platelet and endothelial cell adhesion molecule (PECAM-1), vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1). In this study, the salivary and serum concentrations of these angiogenesis-related proteins in relation to smoking and periodontitis were examined. Material and methods Full-mouth periodontal status together with unstimulated whole saliva and serum samples was collected from 78 individuals, including 40 periodontitis patients (20 smokers and 20 nonsmokers) and 38 periodontally healthy controls (20 smokers and 18 nonsmokers). The Luminex (R)-xMAP (TM) technique was used for protein analyses. Results Concentrations of all tested proteins in saliva as well as VEGF in serum were significantly higher in periodontitis patients than in healthy controls. In smokers, serum concentrations of endoglin (p = 0.017) and sICAM-1 (p = 0.001) were elevated in comparison to nonsmokers. After adjusting for smoking and gender, periodontitis associated significantly with salivary concentrations of b-FGF, PECAM-1, VEGF, sICAM-1, and sVCAM-1 (p < 0.01). Conclusion Taken together, salivary concentrations of b-FGF, PECAM-1, and VEGF associate with periodontitis. The suppressive effect of smoking on salivary marker levels is limited to periodontitis patients only.Publication Metadata only Effect of smoking on saliva and serum levels of OPG, RANKL andIL-34 levels following periodontal treatment(2021-11-05) DOĞAN, BAŞAK; ARIKAN V., DOĞAN B.Publication Metadata only Yaşlanma ve periodontal sağlık(Türkiye Klinikleri (Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş.), 2022-01-01) ÖZTÜRK ÖZENER, HAFİZE; AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; ÖZTÜRK H., AĞRALI Ö. B., DOĞAN B.