Person: DOĞAN, BAŞAK
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DOĞAN
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BAŞAK
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Publication Metadata only Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner-masked, randomized, controlled clinical trial(AMER ACAD PERIODONTOLOGY, 2018) DOĞAN, BAŞAK; Yildirim, Selin; Ozener, Hafize Ozturk; Dogan, Basak; Kuru, BaharBackground: This study aims to evaluate the effects of two different concentrations of topical hyaluronic acid (HA) on postoperative patient discomfort and wound healing of palatal donor sites after free gingival graft (FGG) surgery. Methods: Thirty-six patients requiring FGG were randomly assigned into three groups in an examiner-masked, randomized, controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% HA gels were used in test groups 1 and 2, respectively. Gels were applied on donor sites and protected with periodontal dressing in the test groups, whereas the wound was covered only with periodontal dressing in the control group. On days 3, 7, 14, and 21, pain and burning sensation were recorded using a visual analog scale (VAS) as well as other parameters such as complete epithelization (CE) and color match on days 3, 7, 14, 21, and 42. Results: Test groups experienced less pain than the control group on days 3 and 7 (P < 0.001 and P < 0.001, respectively). Mean VAS score for burning sensation was higher in the control group on day 3 compared with test groups 1 and 2 (P = 0.03 and P = 0.02, respectively). CE in all patients was achieved on day 21 in both test groups, whereas it was achieved on day 42 in the control group. The test groups showed higher color match scores than the control group on days 21 (P < 0.001 and P < 0.001, respectively) and 42 (P = 0.004 and P = 0.002, respectively). Conclusion: Topical application of HA exhibits positive impact on postoperative pain and burning sensation, and accelerates palatal wound healing in terms of epithelization and color match.Publication Metadata only The relationship between vitamin D receptor gene polymorphisms and periodontitis in turkish individuals with type 2 diabetes mellitus(2022-07-01) DOĞAN, BAŞAK; MEGA TİBER, PINAR; Yildiz A. S., Ustundag F. D., Tiber P., Dogan B.© 2022 Wolters Kluwer Medknow Publications. All rights reserved.Background and Aim: Vitamin D receptor (VDR) gene polymorphisms have been implicated in the pathogenesis of many diseases, such as periodontitis and diabetes mellitus (DM). The present study aimed to evaluate the distributions of VDR polymorphisms in diabetic individuals with healthy periodontium (DMH), diabetic individuals with periodontitis (DMP), nondiabetic individuals with healthy periodontium (H), and nondiabetic individuals with periodontitis (P). Material and Methods: A total of 200 individuals (DMH = 40, DMP = 60, H = 40, and P = 60) were recruited. All clinical periodontal parameters, demographical, and biochemical variables were recorded. Blood samples were collected, and genomic DNA was isolated by Purelink® Genomic DNA Mini Kit. Genotyping of VDR polymorphisms ApaI, BsmI, FokI, and TaqI were determined by real-time polymerase chain reaction (PCR) using allele-specific probes. Results: The distribution of the BsmI variant showed differences between DMH and H groups (P = 0.034). In addition, carrying the GG genotype (OR = 0.317; 95% CI = 0.126-0.797; P = 0.013) and the G allele (OR = 2.373; 95% CI = 1.203-4.681; P = 0.012) increased the risk of type 2 DM. Moreover, it was determined that the frequency of CC genotype of FokI variant was higher in DMP compared to DMH (P = 0.046). It was determined that having the CC genotype (OR = 2.706; 95% CI = 1.185-6.176; P = 0.017) and the C allele (OR = 1.917; 95% CI = 0.995-3.694; P = 0.049) increased the risk of periodontitis among diabetic individuals. No differences were detected among groups in the genotype and allele distributions of ApaI and TaqI variants (P > 0.05). Conclusions: The present study showed that the BsmI variant was a risk factor for DM among periodontally healthy individuals and the FokI variant for periodontitis among diabetic individuals.Publication Metadata only Effect of non-surgical periodontal treatmenton salivary IL-13 levels in periodontitis with andwithout type 2 diabetes(2022-06-10) YILDIRIM, HATİCE SELİN; İYİGÜN, SEZGİ; DOĞAN, BAŞAK; YILDIRIM H. S., KALKAN Y., İYİGÜN S., DOĞAN B.Background & Aim: Interleukin (IL)-13 is an anti-inflammatory and fibrogenic cytokine activated by T helper 2 cells. It has been shown that IL-13 inhibits pro-inflammatory cytokine synthesis and osteoclastogenesis. The aim of the study was to determine the effect of non-surgical periodontal treatment (NSPT) on salivary IL-13 levels in periodontitis patients with and without type 2 diabetes mellitus (T2DM). Methods: A total of 48 subjects, 12 systemically and periodontally healthy (H), 12 periodontitis with well controlled T2DM, 12 periodontitis with poorly controlled T2DM and 12 systemically healthy periodontitis, were recruited for the study. All periodontitis patients belonged to either Stage III or IV periodontitis. At baseline, all clinical parameters including plaque index, gingival index, bleeding on probing, probing depth and clinical attachment loss were recorded, and the saliva samples were collected from all subjects, at 3 months following the NSPT only from periodontitis groups. Salivary IL-13 levels were analysed by enzyme-linked immunosorbent assay. This study was supported by the grant from Marmara University Scientific Research Projects Coordination Unit #SAG-A-080519-0172. Results: All clinical parameters were higher in all periodontitis groups than the healthy subjects at baseline (p < 0.05) and improved 3 months after NSPT in all periodontitis groups (p < 0.05). At baseline, salivary IL-13 levels were lower in all periodontitis groups compared to H group (p < 0.05) but were similar among 3 periodontitis groups (p > 0.05). At 3 months following NSPT IL-13 levels were increased in all 3 periodontitis groups compared to baseline (p < 0.05). Conclusions: This study has revealed that low levels of salivary IL-13 are associated with periodontitis not T2DM. IL-13 may be used as a biomarker for both the diagnosis and treatment of periodontitis.Publication Metadata only Yaşlı Bireylerde Cerrahi Olmayan Periodontal Tedavi Yaklaşımı(Türkiye Klinikleri Yayınevi, 2022-12-01) ÖZTÜRK ÖZENER, HAFİZE; AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; Öztürk Özener H., Ağralı Ö. B., Doğan B.Publication Metadata only Yaşlı bireylerde cerrahi olmayan periodontal tedavi yaklaşımı(Türkiye Klinikleri, 2022-01-01) ÖZTÜRK ÖZENER, HAFİZE; AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; ÖZTÜRK H., AĞRALI Ö. B., DOĞAN B.Publication Metadata only Lack of Serotype Antigen in A. actinomycetemcomitans(SAGE PUBLICATIONS INC, 2010) DOĞAN, BAŞAK; Kanasi, E.; Dogan, B.; Karched, M.; Thay, B.; Oscarsson, J.; Asikainen, S.Aggregatibacter actinomycetemcomitans is divided into 6 serotypes. Occurrence of non-serotypeable strains is known, but background reasons are unclear. We hypothesized that non-serotypeable strains represent new serotypes or have altered expression of serotype-specific polysaccharide antigen (S-PA). We first characterized 311 strains from 189 individuals using both immunoassay-and PCR-based serotyping. Next, using natural human infection and rabbit immunization approaches, we clarified whether the phenotypically non-serotypeable strains expressed S-PA. Immunoassay identified serotypes a-f among 216 strains from 159 individuals. The remaining 95 strains from 30 individuals were phenotypically non-serotypeable. Yet, all these strains were identified by PCR-typing as serotype a-, b-, c-, or f. Non-serotypeability was confirmed by Western immunoblot with respective rabbit antisera. Patient sera remained non-reactive with autologous non-serotypeable strains at the serotype-specific region. Rabbit immunization with a phenotypically non-serotypeable strain induced no antibody production against S-PA. Thus, phenotypically non-serotypeable strains did not include novel serotypes, but lacked S-PA expression.Publication Metadata only Salivary MMP-8, MAF, and IL-34 levels in non-surgical periodontal treatment of gingivitis patients(2022-06-10) DOĞAN, BAŞAK; GÖRGÜLÜ N. G., DOĞAN B.Background and Aim: Specific biomarkers' diagnostic ability for peri-odontitis has been identified and widely studied; however, such stud-ies targeting gingivitis are rather rare. The aim of the study was toevaluate the levels of matrix metalloproteinase (MMP-8), Interleukin(IL)-34, and macrophage activating factor (MAF) in the saliva of peri-odontally healthy and gingivitis participants and to compare thechanges following non-surgical periodontal treatment (NSPT) Methods: A total of 36 subjects, 18 periodontally healthy and 18 gingi-vitis, were recruited to the study. The clinical periodontal parameterswere recorded, and the saliva samples were collected from all subjectsat baseline. Gingivitis patients received NSPT, and all clinical peri-odontal parameters and saliva samples were re-collected at 3 months.MMP-8, MAF, and IL-34 levels were analyzed by using ELISA. Thisstudy was supported by grants from Marmara University ScientificResearch Projects Coordination Unit #SAG-A-230119-0014.Results: All clinical parameters were higher in the gingivitis group thanthe healthy ones at baseline and improved at 3 months after NSPT ingingivitis patients (p< 0.05). Salivary MMP-8 and IL-34 levels weresignificantly higher in gingivitis patients compared to healthy ones atbaseline (p< 0.05). The salivary MMP-8 levels in the gingivitis groupdecreased at 3 months compared to baseline (p=0.008). However,salivary IL-34 levels remained unchanged throughout the study period(p> 0.05). The salivary MAF levels were similar between gingivitis andhealthy groups at baseline (p> 0.05), whereas significantly decreasedat 3 months compared to baseline (p=0.002).Conclusions: The results of this study confirm that salivary MMP-8plays a role as a reliable biological marker in the pathogenesis of gingi-vitis, and NSPT is effective in decreasing its levels. In addition, peri-odontal inflammation was found to alter salivary IL-34 levels ingingivitis patientsPublication Metadata only Effect of non-surgical periodontal treatment serum sirt-1 sevivelerine etkisi on salivary and serum sirt-I levels(2022-11-09) DOĞAN, BAŞAK; İYİGÜN S., GÖRGÜLÜ N. G., DOĞAN B.Publication Metadata only Clarithromycin reduces recurrent cardiovascular events in subjects without periodontitis(ELSEVIER IRELAND LTD, 2006) DOĞAN, BAŞAK; Paju, Susanna; Pussinen, Pirkko J.; Sinisalo, Juha; Mattila, Kimmo; Dogan, Basak; Ahlberg, Jari; Valtonen, Ville; Nieminen, Markku S.; Asikainen, SirkkaInflammation leading to acute coronary syndrome may be triggered by bacteria causing periodontal infection. We investigated if recurrence of cardiovascular events in unstable coronary patients are associated with periodontitis or microbiological/serological markers of it. Periodontitis-related parameters of 141 patients with acute non-Q-wave infarction or unstable angina pectoris, who participated in a double-blind, placebo-controlled study with clarithromycin for 3 months, were adjusted to the occurrence of a recurrent cardiovascular event during a follow-up period (average 519 days). In the age group under 65 years the patients with periodontitis had a univariate odds ratios (OR) 95% confidence intervals (95% CI) of 5.0 (1.02-24.55) for a recurrent cardiovascular event in comparison with patients without periodontitis. Dental status correlated positively with serum lipopolysaccharide concentrations and combined IgG antibody response to Actinobacillus actinoinycetemcomitans and Porphyromonas gingivalis. The end point frequency did not differ between clarithromycin and placebo groups in bacterium-positive, seropositive, or periodontitis patients. Fewer end points in clarithromycin group were seen in bacterium-negative, seronegative, edentulous, and non-periodontitis patients. Periodontitis and edentulousness are associated with recurrent cardiovascular events, especially in younger patients. Long-term clarithromycin therapy seems to be beneficial in prevention of recurrent cardiovascular events in non-periodontitis but not in periodontitis patients. (c) 2005 Elsevier Ireland Ltd. All rights reserved.Publication Metadata only Salivary and serum markers of angiogenesis in periodontitis in relation to smoking(SPRINGER HEIDELBERG, 2021) DOĞAN, BAŞAK; Yilmaz Sastim, Cigdem; Gursoy, Mervi; Kononen, Eija; Kasurinen, Akseli; Norvio, Susanna; Gursoy, Ulvi Kahraman; Dogan, BasakObjective Angiogenesis is essential in maintenance of periodontal homeostasis, and it is regulated by growth factors and cytokines, including basic fibroblast growth factor (b-FGF), endoglin, platelet and endothelial cell adhesion molecule (PECAM-1), vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1). In this study, the salivary and serum concentrations of these angiogenesis-related proteins in relation to smoking and periodontitis were examined. Material and methods Full-mouth periodontal status together with unstimulated whole saliva and serum samples was collected from 78 individuals, including 40 periodontitis patients (20 smokers and 20 nonsmokers) and 38 periodontally healthy controls (20 smokers and 18 nonsmokers). The Luminex (R)-xMAP (TM) technique was used for protein analyses. Results Concentrations of all tested proteins in saliva as well as VEGF in serum were significantly higher in periodontitis patients than in healthy controls. In smokers, serum concentrations of endoglin (p = 0.017) and sICAM-1 (p = 0.001) were elevated in comparison to nonsmokers. After adjusting for smoking and gender, periodontitis associated significantly with salivary concentrations of b-FGF, PECAM-1, VEGF, sICAM-1, and sVCAM-1 (p < 0.01). Conclusion Taken together, salivary concentrations of b-FGF, PECAM-1, and VEGF associate with periodontitis. The suppressive effect of smoking on salivary marker levels is limited to periodontitis patients only.