Person: ARICIOĞLU, FEYZA
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ARICIOĞLU
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FEYZA
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Publication Open Access Inhibition of Neuronal Nitric Oxide Synthase and Soluble Guanylate Cyclase Prevents Depression-Like Behaviour in Rats Exposed to Chronic Unpredictable Mild Stress(WILEY, 2012-03) ARICIOĞLU, FEYZA; Yazir, Yusufhan; Utkan, Tijen; Aricioglu, FeyzaDepression is the most common psychiatric disorder. It is well established that endogenous nitric oxide (NO) contributes to chronic unpredictable mild stress (CUMS)-induced depression. The aim of this study was to investigate brain-derived neurotropic factor (BDNF) expression in CUMS-induced depression-like behaviour in rats. Rats were exposed to CUMS for 5 weeks. A specific and selective nNOS inhibitor, 3-bromo-7-nitroindazole (3-Br-7-NI; 20 mg/kg/day, i.p.), and a specific soluble guanylate cyclase (sGC) inhibitor, 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one (ODQ; 10 mg/kg/day, i.p.), were administered during CUMS. The forced swimming test (FST) was used to assess despair and sucrose consumption, and sucrose preference test was used to assess anhedonia that are the main symptoms of the depression. We show that both 3-Br-7-NI and ODQ administration during CUMS suppressed CUMS-induced, depression-like behavioural changes, including reduced sucrose preference, body-weight and locomotor activity as well as increased immobility time in the FST. CUMS also significantly decreased BDNF protein levels in the CA1 and CA3 regions of the hippocampus, which was reversed by 3-Br-7-NI and ODQ administration. Our findings suggest a novel role for nNOS and sGC-cGMP in the development of the CUMS model of depression.Publication Open Access Neuroinflammation in Schizophrenia: A Critical Review and The Future(KURE ILETISIM GRUBU A S, 2016-12) ARICIOĞLU, FEYZA; Aricioglu, Feyza; Ozkartal, Ceren Sahin; Unal, Gokhan; Dursun, Serdar; Cetin, Mesut; Mueller, NorbertSchizophrenia is a serious mental illness that affects approximately 1% of the population worldwide, with positive, negative and cognitive dysfunctions and a significant deterioration in psychosocial functioning. Interactions between genetic predisposition and environmental stressors at the early stages of life, and subsequently a molecular level neurodegeneration process are important in the development of schizophrenia. Current approaches suggest that cytokines-induced neuroinflammation might have a role in the development of several psychiatric disorders, including schizophrenia. Uncontrolled microglial activation, increase in pro-inflammatory cytokines, and subsequent neurotransmitter dysfunctions can induce schizophrenia. Microglial activation induced by pro-inflammatory cytokines in central nervous system is responsible for the initiation and proceeding of the inflammatory process and consequently developing neurodegeneration. Here in this review, we aimed to provide an overview to the latest findings related to the cytokines-mediated peripheral and central immune responses in the development of schizophrenia.Publication Metadata only Anti-inflammatory properties of brilliant blue G on chronic unpredictable mild stress-induced changes in rat hippocampus(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017) ARICIOĞLU, FEYZA; Aricioglu, F.; Bastaskin, T.; Kandemir, C.; Sirvanci, S.; Ozkartal, C.; Utkan, T.Publication Open Access Effects of agmatine on cognitive functions during vascular dementia in biological aging through eNOS and BDNF expression(TAYLOR & FRANCIS LTD, 2017-04-03) ARICIOĞLU, FEYZA; Bagci, Bulent; Utkan, Tijen; Yazir, Yusufhan; Aricioglu, Feyza; Ozturk, Gokce Sevim; Sarioglu, YusufObjective: Biological aging has been recognized to cause impairment of memory and the development of vascular dementia. Based on our previous work, agmatine has been shown to have a beneficial effect and might have therapeutic potential on cognitive functions, including learning and memory. The aim of the present study was to examine the possible effect of agmatine on biological aging-induced vascular endothelial dysfunction and associated dementia in rats. Methods: We used three different age groups (4-month-olds, 18-month-olds and 24-montholds; n = 12 in each group) of control and agmatine-treated rats. Control animals received physiological saline for 8 weeks. Agmatine sulfate (40 mg/kg, twice daily) was given to the agmatine groups orally for 8 weeks. Herein, we investigated the effects of agmatine on systolic blood pressure (SBP), nitric oxide (NO)-mediated endothelium-dependent and - independent vasorelaxant responses in thoracic aorta, cognitive performance (passive avoidance test; PAT, and Morris water maze test; MWMT), endothelial nitric oxide synthase (eNOS) expression and both hippocampal and amygdaloid brain-derived neurotrophic factor (BDNF) expression in aged rats. Results: We found cognitive decline, endothelial dysfunction and reduced eNOS and BDNF expression in aged rats. All these changes may result from aging-induced vascular dementia. We also found that chronic treatment with agmatine may improve amygdala-dependent emotional and spatial learning and memorial performance, and endothelial function, and may regulate eNOS and BDNF protein expression in aged rats. Conclusion: Results of the current study point out that chronic agmatine treatment may prevent endothelial dysfunction associated with vascular dementia through eNOS and BDNF expression in aged rats.Publication Open Access Comparison of behavioural and molecular effects of two different schizophrenia models induced by subchronic MK-801 administration in rats(MARMARA UNIV, FAC PHARMACY, 2018-04-06) ARICIOĞLU, FEYZA; Unal, Gokhan; Aricioglu, FeyzaSchizophrenia is a severe psychiatric disorder with about 1% prevalance. NMDA receptor antagonists such as Phencyclidine (PCP) and MK-801 are commonly used for modeling schizophrenia in rodents. In literature, despite of the concensus about subchronic PCP administration (commonly 7 days, bi-daily administration followed by a 1 week washout period), there are different subchronic administration regimens for MK-801 beside 7 days, bidaily (MK-801-7), such as 14 days (MK-801-14) daily or 28 days daily injections. In this study, we aimed to compare two prevalant MK-801 models (MK-801-7 and MK-801-14, 0.2 mg/kg)in both behavioural and molecular changes. Wistar Hannover rats grouped as control (n=10), MK-801-14 (n=8) and MK-801-7 (n=8). Prepulse inhibition of acustic startle response (PPI), novel object recognition test (NORT), social interaction (SI) and Morris's water maze (MWM) tests were used for behavioural analyzes while real time polimerase chain reaction (Rt-PCR) was conducted for molecular analyzes of glutamic acid decarboxilase 67 (GAD67) and parvalbumin. Our results showed decreased PPI in MK-801-14 and MK-801-7 groups. Moreover, in both models platform finding latencies were increased and swimming time in platform area was decreased in MWM. MK-801-14 and MK-801-7 reduced following and raised avoiding behaviours in SI. In Rt-PCR, GAD67 mRNA levels were decreased by MK-801-14 and MK-801-7 administrations. However, only MK-801-7 decreased discrimination index in NORT and parvalbumin mRNA levels. In this study, it has been showed that although MK-801-14 and MK-801-7 administrations revealed smiliar schizophrenia like symptoms in rats, MK-801-7 has partial superiories in certain aspects.Publication Metadata only Harmane suppresses microglial neuroinflammatory response and induce antidepressant-like effect in rats(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017) ARICIOĞLU, FEYZA; Aricioglu, F.; Arkan, G.; Kandemir, C.; Sirvanci, S.; Ozkartal, C.; Utkan, T.Publication Open Access Synthesis and anticonvulsant activity of some 2-pyrazolines derived from chalcones(ELSEVIER SCIENCE BV, 2017-05) KAYMAKÇIOĞLU, BEDİA; Beyhan, Nagihan; Kocyigit-Kaymakcioglu, Bedia; Gumru, Salih; Aricioglu, FeyzaSynthesis of chalcones (1,3-diarylprop-2-en-1-ones) and 2-pyrazoline derivatives has been an active field of research due to their established pharmacological effects. In this study, a series of chalcones were prepared with methyl aryl ketones and substituted aldehydes in the presence of sodium hydroxide and methanol through Claisen-Schmidt condensation. 3,5-Disubstituted4,5-dihydro-1H-pyrazole-1-carbothioamides were synthesized by refluxing selected chalcones and thiosemicarbazide in alkaline medium. Similarly N-3,5-trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides were synthesized by refluxing selected chalcones with N-(4-chlorophenyl) semicarbazide in alkaline medium. Structures of the synthesized compounds were confirmed by elemental analysis and spectral (UV, IR, H-1 NMR, C-13 NMR, and mass) data, which were in line with the proposed structures. All compounds were tested for their anticonvulsant activity using pentylenetetrazole induced seizure (PTZ) and maximal electroshock seizure (MES) tests in mice at a dose level of 50 mg/kg. Among the 2-pyrazoline-1-carbothioamide derivatives, 5-(2,6-dichlorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide (2e) reduced grade-5 seizure activity and also increased survival rate in PTZ test. In MES test, 5-(4-methoxyphenyl)-3-[4-(methylsulphonyl) phenyl]-4,5-dihydro-1H-pyrazole-1-carbothioamide(2g) has not only decreased seizure severity, but also increased survival rate. Among the 2-pyrazoline-1-carboxamide derivatives, 3-(5-bromothiophen-2-yl)-N-(4-chlorophenyl)-5-(2,6-dichlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide (3d) having 5-bromothiophen and 2,6-dichlorophenyl moieties and N-(4-chlorophenyl)-5-(2,6-dichloro-phenyl)-3-(5-chlorothiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboxamide (3e) having 5-chlorothiophen and 2,6-dichlorophenyl moieties showed remarkable activities in PTZ test. Among all tested derivatives, compound 3d was found to be the most active one and reduced grade-5 seizure severity and also increased survival rate. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.Publication Metadata only Neuroprotective effects of agmatine in antineoplastic drugs induced neurotoxicity: In vitro study(PERGAMON-ELSEVIER SCIENCE LTD, 2019) ARICIOĞLU, FEYZA; Binnetoglu, Damla; Hacimuftuoglu, Ahmet; Aricioglu, FeyzaAims: The effects of agmatine, an endogenous substance known to have a neuroprotective effect against neurotoxicity has been investigated. Material and methods: The primary neuron culture obtained from neonatal rats was exposed to toxicity with paclitaxel and cisplatin and the effect of agmatine on both acute (1 h) and chronic (24 h) exposure was demonstrated by biochemical and molecular analyses. It was demonstrated that the effect of agmatine before and after agmatine was induced by neurotoxicity before agmatine and the effect of agmatine on the formed and occuring toxicities. In addition to the results of cell viability assay, total oxidant capacity and total antioxidant capacity, we have found the opportunity to elaborate on our molecular mechanisms by elaborating our findings with apoptotic and inflammation markers such as caspase 3, kaspase 9 and TNF alpha. Key findings: The results of our study revealed the effect profile of a protective molecule against pathological neural deaths due to neurodegeneration not only in neurotoxicity due to anticancer drugs. Significance: In this context, we tried to reverse neurotoxicity due to anticancer drugs by using agmatine the duration (1 and 24 h) and dosage (10-5M and 10-6 M) determined.Publication Metadata only Effect of agmatine on long-term changes induced by early developmental stressors in maternal separation model of depression/anxious-like behaviors(ELSEVIER, 2019) ARICIOĞLU, FEYZA; Zortul, H.; Yilmaz, B.; Aricioglu, F.Publication Metadata only Effects of agmatine on Akt/GSK-3beta/betacatenin signaling pathway in SH-SY5Y cell culture: Relevance to schizophrenia(ELSEVIER SCIENCE BV, 2019) ARICIOĞLU, FEYZA; Unal, G.; Aricioglu, F.; Dokumaci, A. H.; Yerer-Aycan, M. B.; Ozkartal-Sahin, C.