Person: YEGEN, ŞEVKET CUMHUR
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YEGEN
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ŞEVKET CUMHUR
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Publication Metadata only Bombesin ameliorates colonic damage in experimental colitis(1999) YEGEN, BERRAK; Güllüoğlu, B. M.; Kurtel, H.; Güllüoğlu, M. G.; Aktan, A. O.; Yeğen, B. C.; Dizdaroğlu, F.; Yalin, R.; Yeğen, B. C.In the present study we investigated the possible therapeutic effects of bombesin on an experimentally induced colitis model in rats. Inflammation of the colon was induced by a single intracolonic administration of 30 mg of 2,4,6-trinitrobenzene sulfonic acid (TNBS) at 8 cm from the anus. Immediately after the induction of colitis, some rats were given bombesin (10 microg/kg; subcutaneously) three times a day for 14 days, while another group received vehicle treatment. On day 14, the rats were decapitated and plasma carbonyl content and tissue myeloperoxidase level, as an index of granulocyte infiltration into intestinal tissue, were determined in order to obtain an objective evaluation of colonic injury. In the colitis group, increased macroscopic damage score, elevated MPO level and high plasma carbonyl content, together with the microscopic appearance revealed severe inflammatory changes resembling IBD. Bombesin treatment attenuated the TNBS-induced colonic damage and stimulated histopathologically apparent mucosal proliferation, suggesting that bombesin may play a role in protecting gut integrity.Publication Metadata only Retained abdominal gallstones during laparoscopic cholecystectomy(EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, 2005) TÜNEY, DAVUT; Manukyan, MN; Demirkalem, P; Gulluoglu, BM; Tuney, D; Yegen, C; Yalin, R; Aktan, AOBackground: Although gallbladder perforation with spillage of bile and gallstones is quite common, the approach to retained gallstones in the abdomen still is controversial. Methods: Laparoscopic cholecystectomy (LC) was performed on 580 patients with gallstones. In 101 (17%) patients, gallbladder perforations occurred during surgery, and in 43 (7%) patients, stone(s) were spilled into the peritoneal cavity. In 24 (4%) patients, gallstone(s) were not cleared entirely from the peritoneal cavity. These patients were invited to return for physical examination and biochemical tests. To investigate the retained abdominal gallstone(s) computed tomography was performed. Results: Twenty-two patients were investigated. After a median follow-up period of 121 months, retained abdominal gallstone(s) were shown in 2 patients by computed tomography. Biochemical tests were normal except in 1 patient with chronic hepatitis. All of the patients were happy with their surgical results. Conclusions: This study revealed no harm caused by retained abdominal gallstone(s) during LC after long-term follow-up evaluation. (c) 2005 Excerpta Medica Inc. All rights reserved.Publication Metadata only Radiofrequency Ablation of Benign Symptomatic Thyroid Nodules: Prospective Safety and Efficacy Study(SPRINGER, 2015) GÜLLÜOĞLU, MAHMUT BAHADIR; Ugurlu, M. Umit; Uprak, Kivilcim; Akpinar, Ihsan N.; Attaallah, Wafi; Yegen, Cumhur; Gulluoglu, Bahadir M.Radiofrequency ablation (RFA) is a relatively novel procedure in the management of benign nodular goiter. This study was conducted to evaluate the safety and efficacy of ultrasound (US)-guided percutaneous RFA for benign symptomatic thyroid nodules as an alternative to surgery. The study involved patients for whom a fine needle aspiration biopsy had proved a diagnosis of benign nodular goiter and had nodule-related symptoms such as dysphagia, cosmetic problems, sensation of foreign body in the neck, hyperthyroidism due to autonomous nodules or fear of malignancy. Percutaneous RFA was performed as an outpatient procedure under local anesthesia. The primary outcome was an evaluation of the changes in symptom scores (0-10) for pain, dysphagia and foreign body sensation at the 1st, 3rd, and 6th months after the RFA procedure. Secondary outcomes were assessing volume changes in nodules, complication rates, and changes in thyroid function status. A total of 33 patients (24 % female, 76 % male) and a total of 65 nodules were included into the study. More than one nodule was treated in 63.6 % of the patients. We found a statistically significant improvement from baseline to values at the 1st, 3rd, and 6th months, respectively, as follows: pain scores (2.9 +/- A 2.7, 2.3 +/- A 2.01, 1.8 +/- A 1.7, and 1.5 +/- A 1.2, p 0.005), dysphagia scores (3.9 +/- A 2.7, 2.6 +/- A 1.9; 1.7 +/- A 1.6, and 1.1 +/- A 0.3, p 0.032), and foreign body sensation scores 3.6 +/- A 3, 2.5 +/- A 2.2; 1.6 +/- A 1.5, and 1.1 +/- A 0.4, p 0.002).The mean pre-treatment nodule volume was 7.3 +/- A 8.3 mL. There was a statistically significant size reduction in the nodules at the 1st, 3rd, and 6th months after RFA (3.5 +/- A 3.8, 2.7 +/- A 3.4, and 1.2 +/- A 1.7 mL, p 0.002). The volume reduction was found to be 74 % at 6th months following the RFA (p 0.005). 8 patients had autonomously functioning nodules in the pre-treatment period, 50 % (n: 4) became euthyroid at the 6th month after RFA. There were no complaints other than pain (12 %). RFA can be an alternative treatment modality in the management of benign symptomatic thyroid nodules. The results showed that it is a safe and effective procedure.Publication Metadata only Role of endothelins in trinitrobenzene sulfonic acid-induced colitis in rats(KARGER, 1999) YEGEN, BERRAK; Gulluoglu, B; Kurtel, H; Gulluoglu, MG; Yegen, C; Aktan, AO; Dizdaroglu, F; Yalin, R; Yegen, BCTo determine the role of endothelins (ET) on experimental colitis, following intracolonic trinitrobenzene sulfonic acid administration, rats were given orally either bosentan (BS), a nonselective ET receptor antagonist (100 mg/kg in 5% arabic gum), or arabic gum by gavage for 2 or 14 days. Macroscopic damage scores obtained in the vehicle (1.4 +/- 0.4), acute (4.8 +/- 0.6) and chronic (3.8 +/- 0.3) colitis groups were significantly higher than in the control group (0). BS treatment reduced the scores in both acute (3 +/- 0.5) and chronic (2.3 +/- 0.5) colitis groups. Myeloperoxidase (MPO) activities of colonic tissues were elevated in acute and chronic colitis groups (325.1 +/- 44.9 and 431.8 +/- 54.6 U/g wet weight) as compared with the control group (73.6 +/- 11 U/g wet weight). Plasma protein oxidation levels were found to be significantly increased in the chronic colitis group (1,158.1 +/- 63.4 nmol/ml) compared with the control, ethanol and acute colitis groups (274.3 +/- 23.1, 490 +/- 52.2 and 422.2 +/- 50.5 nmol/ml). BS treatment significantly reduced both the protein oxidation level (375.5 +/- 46.9 nmol/ml) and MPO activity (167.5 +/- 35.8 U/g wet weight). The results of the present study suggest the involvement of ETs in the pathogenesis of colonic injury in this animal model of colitis.Publication Metadata only Early prediction of normocalcemia after thyroid surgery(SPRINGER, 2005) GÜLLÜOĞLU, MAHMUT BAHADIR; Gulluoglu, BM; Manukyan, MN; Cingi, A; Yegen, C; Yalin, R; Aktan, AOHypocalcemia is the principal factor that determines length of hospital stay after thyroid surgery. Seventy-nine patients who underwent thyroidectomy were prospectively evaluated in order to define risk factors for postoperative hypocalcemia. Serum samples were taken postoperatively at 8, 14, 24, and 48 hours to measure total calcium levels. The slope of change in serum calcium level between each sample time was calculated. Patients were also examined for age, gender, surgical indications, type and extension of surgery, thyroid function, presence of substernal extension, initial operation versus reoperation, and application of parathyroid autotransplantation. All comparisons were made between hypocalcemic and normocalcemic groups. Hypocalcemia occured in 15 (19%) patients. In univariate analysis, type and extent of thyroidectomy, serum calcium levels at each time point, as well as the slope of change in serum total calcium levels between 8 and 14 hours were found to be significantly predictive of normocalcemia. All patients who underwent hemithyroidectomy and who had a`positive or neutral slope of calcium change after surgery remained normocalcemic. By multivariate logistic regression analysis, only the slope of change in calcium levels within the first 14 postoperative hours independently predicted calcium status after thyroidectomy. All patients who undergo unilateral thyroid surgery who have a positive/neutral slope of change in serum total calcium levels within the first 14 hours after surgery can be safely discharged early if they have no other risks.Publication Metadata only Laparoscopic cholecystectomy: Is it a conscious preference among Turkish patients with symptomatic gallstones? Prospective study(SPRINGER, 2004) GÜLLÜOĞLU, MAHMUT BAHADIR; Cingi, A; Dusunceli, F; Gulluoglu, BM; Yegen, C; Aktan, AO; Yalin, RLaparoscopic cholecystectomy (LC) has the advantages of early return to full daily activity, early return to work, and better cosmetic result, as well as quickly resolving pain. Yet how this information about the procedure influences a patient's attitude toward laparocopy is not known. In this study we analyzed the factors that play role in the decision-making process of patients who choose laparoscopic surgery, and we also evaluated patients' knowledge of laparoscopy and their expectations. A questionnaire was used in evaluating 98 patients suffering from symptomatic cholelithiasis scheduled for elective laparoscopic cholecystectomy between January 2001 and January 2002. Females constituted 81% of the study population. Most of the patients (56%) were housewives. While 45% of the patients had an educational status of primary school degree only, 14% had graduated from a university. Forty-three patients described their level of knowledge about laparoscopy as low (had only heard about laparoscopy). In 61% of the patients the surgeon was the sole decision maker about the type of the operation. Almost none of the patients had a preference for the time of discharge from the hospital after surgery, and only three of the actively working patients offered a time interval for return to work. From this study we concluded that most patients have inadequate information about laparoscopic surgery, that the type of operation is dictated mostly by the surgeon, and that early discharge and early return to work are not important for many patients.