Person: YEGEN, ŞEVKET CUMHUR
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YEGEN
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ŞEVKET CUMHUR
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Publication Metadata only Bombesin ameliorates colonic damage in experimental colitis(1999) YEGEN, BERRAK; Güllüoğlu, B. M.; Kurtel, H.; Güllüoğlu, M. G.; Aktan, A. O.; Yeğen, B. C.; Dizdaroğlu, F.; Yalin, R.; Yeğen, B. C.In the present study we investigated the possible therapeutic effects of bombesin on an experimentally induced colitis model in rats. Inflammation of the colon was induced by a single intracolonic administration of 30 mg of 2,4,6-trinitrobenzene sulfonic acid (TNBS) at 8 cm from the anus. Immediately after the induction of colitis, some rats were given bombesin (10 microg/kg; subcutaneously) three times a day for 14 days, while another group received vehicle treatment. On day 14, the rats were decapitated and plasma carbonyl content and tissue myeloperoxidase level, as an index of granulocyte infiltration into intestinal tissue, were determined in order to obtain an objective evaluation of colonic injury. In the colitis group, increased macroscopic damage score, elevated MPO level and high plasma carbonyl content, together with the microscopic appearance revealed severe inflammatory changes resembling IBD. Bombesin treatment attenuated the TNBS-induced colonic damage and stimulated histopathologically apparent mucosal proliferation, suggesting that bombesin may play a role in protecting gut integrity.Publication Metadata only Pankreati̇koduodenektomi̇ sonrasi yapilan uç yan pankreti̇kojejenostomi̇lerde stent uygulamasi pankreati̇k fi̇stül oranina etki̇li̇ mi̇?(2021-09-12) ATICI, ALİ EMRE; ÖZOCAK, AYŞEGÜL BAHAR; UPRAK, TEVFİK KIVILCIM; COŞKUN, MÜMİN; YEGEN, ŞEVKET CUMHUR; ATICI A. E., ÖZOCAK A. B., UPRAK T. K., COŞKUN M., YEGEN Ş. C.Publication Metadata only A new technique of completely diverted tube ileostomy for the protection of colorectal anastomosis: a pilot study(WILEY, 2020) YEGEN, ŞEVKET CUMHUR; Attaallah, W.; Bulut, A.; Uprak, T. K.; Yegen, C.Aim This study was designed to evaluate a new technique for a completely diverting tube ileostomy achieved through temporary occlusion of the distal ileum using a flexible rubber strip. Methods This prospective interventional study was conducted in one centre. Patients who underwent colorectal resections with a primary anastomosis and who were deemed as requiring a defunctioning stoma were included in the study. After completion of resection and anastomosis, the tube ileostomy was fashioned by inserting a reinforced (spiral) endotracheal tube with an inner diameter of 7.5 mm into the ileum. To provide complete faecal diversion, temporary occlusion of the distal ileum was performed using a flexible rubber strip. The primary outcome of this study was the incidence of complete diversion achieved using this method. Results Fifty consecutive patients underwent a diverted tube ileostomy using the technique described above. Defaecation before removal of the strip did not occur in any of the patients inferring that complete diversion was observed in all patients (100%). The tube was removed at postoperative week 3. After tube removal, the resulting enterocutaneous fistulas closed spontaneously in a median of 6 (2-30) days. Conclusion The diverting tube ileostomy technique using an easily removable rubber strip to defunction the colorectal anastomosis is a safe and effective method that precludes the need to fashion a stoma.Publication Metadata only Intestinal obstruction due to congenital mesenteric band in an adult patient(TURKISH SOC GASTROENTEROLOGY, 2013) YEGEN, ŞEVKET CUMHUR; Attaallah, Wafi; Mokhtare, Sina; Ozden, Gulden; Yegen, CumhurWe report the case of a 30-year-old male patient who was admitted to the Emergency Department with symptoms and signs of intestinal obstruction. There was no history of abdominal surgery or trauma. Abdomen was distended. Abdominal plain X-ray showed intestinal loops with air-fluid levels in the middle area of the abdomen. Computed tomography showed small bowel dilatation and free fluid in the abdomen. A laparotomy was subsequently performed and the intraoperative findings revealed a band extending from the root of the mesentery to the antimesenteric wall of the jejunum. The band was resected; the postoperative course was uneventful. Congenital bands are extremely rare and usually observed in childhood. This case, therefore, represents an unusual surgical problem in an older individual in whom the diagnosis was clinically unexpected.Publication Metadata only Pseudoaneurysm of the left gluteal artery after a pelvic fracture sustained during the Marmara earthquake: Report of a case(SPRINGER-VERLAG, 2001) YEGEN, ŞEVKET CUMHUR; Barlas, A; Aribal, E; Yegen, CAlthough iliac artery injuries caused by pelvic fractures are uncommon, in special circumstances, such as earthquakes, traumatic arterial injury should be carefully investigated. This reports describes a case of an iliac artery pseudoaneurysm causing compressive symptoms that was successfully treated by radiologic embolization.Publication Metadata only Chemical Ablation for Treating Anal Fistulas without Surgical Intervention: Long-Term Results(SAGE PUBLICATIONS INC, 2021) KARA, BURAK; Attaallah, Wafi; Uprak, Tevfik K.; Kara, Burak; Sen, Aliosman; Tuney, Davut; Yegen, CumhurPurposes. This study aimed to evaluate long-term outcomes after the application of a corrosive chemical agent for ablation of epithelial tissue as a non-surgical treatment of anal fistulas. Methods. Adult patients with symptomatic perianal fistula were prospectively included in the study. The fistula tract was irrigated with a 5% silver nitrate solution. The primary outcome measured in this study was the rate of clinical healing after long-term follow-up. Factors that may affect healing were also analysed. Results. A total of 186 patients with anal fistula were analysed. After irrigation with silver nitrate, 82 (44%) patients had complete clinical healing during a median follow-up time of 50 (7-64) months. Patients with intermittent discharge had a significantly higher rate of complete clinical healing than those with continuous discharge (P < .04). Fistulas without abscesses or secondary tracts had a significantly higher rate of complete clinical healing than the other types (P = .007). Conclusion. Chemical ablation of the epithelium of the anal fistula yields promising long-term outcomes in the management of anal fistulas without surgical intervention.Publication Metadata only DOES PGE(2) ACT AS A MEDIATOR FOR ENDOTHELIN RELEASE(CHURCHILL LIVINGSTONE, 1994) HAKLAR, GONCAGÜL; AKTAN, AO; BUYUKGEBIZ, O; YEGEN, C; YALCIN, SH; HAKLAR, G; YALIN, R; ERCAN, STo investigate the effect of iloprost (ZK 36374) and thromboxane synthetase inhibitor UK 38485 on endothelin release by the intestinal vascular endothelium after ischemia/reperfusion (IR) injury, five experimental groups were formed. The groups consisted of sham, control, iloprost treated (ILO), UK 38485 treated (TSI), and iloprost + UK 38485 treated (ILO + TSI) groups. The last three groups received the corresponding agents and then the superior mesenteric artery was clamped for 30 min followed by 90 min reperfusion. Endothelin levels in the portal blood and malondialdehyde (MDA), prostaglandin E(2) (PGE(2)) and leukotriene C-4 (LTC(4)) levels in the intestinal tissue were determined. The MDA levels increased significantly in the control group and this increase was reversed in ILO, TSI, and ILO + TSI groups, the two drugs together showing a synergistic effect in preventing lipid peroxidation. The changes in the LTC, levels were not significant among the groups. The increased endothelin levels in the control group were reversed in ILO and TSI groups but these two agents did not have a synergistic effect. Increased PGE, levels were reversed with iloprost but neither UK 38485 nor the combination of the two agents was effective in decreasing PGE, levels. It is concluded that endothelin release after mesenteric IR injury is relatively unrelated to lipid peroxidation and the lipoxygenase pathway. The cyclooxygenase pathway has a direct effect on endothelin release and PGE, may act as a mediator.Publication Metadata only Enhanced recovery after pancreatic surgery: A prospective randomized controlled clinical trial(WILEY, 2021) ERGENÇ, MUHAMMER; Ergenc, Muhammer; Karpuz, Sakir; Ergenc, Merve; Yegen, CumhurBackground and Objectives The enhanced recovery after surgery (ERAS) protocol is a perioperative care bundle designed to achieve early healing after surgical procedures. This study aims to investigate the effect of the ERAS protocol on postoperative complications, length of hospital stay (LOS), and readmission rates in pancreatic surgery patients. Methods The study was designed as a prospective and randomized controlled study between January 2016 and November 2018 on pancreatic surgery patients. A total of 38 patients were analyzed, 18 of whom were in the ERAS group and 20 in the control group. Patient demographics, intraoperative variables, and postoperative outcomes were recorded. Results The groups were similar regarding age, sex, surgery type, American Society of Anesthesiologists scores, and laboratory results. There was no significant difference in the intraoperative variables. Early oral feeding was preferred, mostly in the ERAS group compared to the control group. Perioperative complication rates, including delayed gastric emptying and pancreatic fistula, LOS, and readmission rates, were similar between the two groups. Conclusions The ERAS protocol provided a minimal decrease in the total complication rates and had no effect on severe complications. Therefore, the ERAS protocol seems feasible and can be applied safely in pancreatic surgery patients.Publication Metadata only Simple provocative maneuvers in renal transplant scintigraphy for detecting urine leak(SPRINGER, 2007) DEDE, FUAT; Dede, Fuat; Ones, Tunc; Caliskan, Billur; Civen, Huseyin; Erdil, Tanju Y.; Inanir, Sabahat; Tuglular, Zubeyde S.; Yegen, Cumhur; Akoglu, Emel; Turoglu, Halil T.Urine leak in the early postoperative period following renal transplantation is a serious complication requiring early identification and aggressive intervention, which significantly reduces the morbidity and mortality. Renal transplant scintigraphy is a noninvasive method to evaluate the perfusion and function of a transplanted kidney and urinary drainage including urine leak. Here, we reported two cases in which the standard transplant renogram failed to demonstrate urine leak. The cases were referred for a diethylenetriaminepentaacetic acid renogram following the transplantation to evaluate the cause of symptoms or elevated serum creatinine level. In both the cases, urine leak was successfully detected following simple maneuvers such as diuretic administration or Foley catheter irrigation. Renal transplant scintigraphy is an effective and safe technique and the use of these simple maneuvers can enhance the diagnostic sensitivity of the transplant renogram in the detection of urine leak.Publication Metadata only Mide MAlign tümörlerinde peritoneal tututlumu belirlemede Ca-125 seviyesinin kullanılması(2022-04-27) COŞKUN, MÜMİN; ÖZOCAK, AYŞEGÜL BAHAR; UPRAK, TEVFİK KIVILCIM; YEGEN, ŞEVKET CUMHUR; COŞKUN M., ÖZOCAK A. B., UPRAK T. K., YEGEN Ş. C.