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YILMAZ, HİLAL

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YILMAZ

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HİLAL

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    PublicationOpen Access
    Comparative studies of GelMA hydrogels: investigating the effect of different source on mechanical, physical and biological properties
    (2024-07-01) YILMAZ, HİLAL; GÜNDÜZ, OĞUZHAN; YILMAZ H., Gursoy S., ÇALIK H., Kazancioglu Y., Yildirim R., ÇAKIR R., GÜNDÜZ O., Ahmed A., ÜSTÜNDAĞ C. B.
    GelMA hydrogels are prominent in biomedical applications due to their innate extracellular matrix mimicking properties. They exhibit favorable properties for cell proliferation and formation of light-induced hydrophilic cross-linked structures. However, there is limited research on the effect of variations in the starting material (gelatin) on the physical, mechanical and biological properties. In this study, Gelatin Methacrylic Anhydride (GelMA) hydrogels were synthesized from two different products of type B gelatin and loaded with polyvinylpyrrolidone (PVP) nanoparticles by electrospray method. Chemical and structural analyses were performed by FTIR, 1HNMR, TNBS and SEM, respectively. Mechanical properties were evaluated by compression tests. Cytocompatibility was evaluated by XTT analysis. GelMA hydrogels obtained from two brands have suitable pore size, mechanical strength, swelling properties and cytocompatibility, making them suitable for various biomedical applications. In addition, the addition of PVP nanoparticles can make them useful for drug delivery applications.
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    PublicationOpen Access
    Development of bilayer tissue-engineered scaffolds: combination of 3D printing and electrospinning methodologies
    (2024-07-01) YILMAZ, HİLAL; GÜNDÜZ, OĞUZHAN; YILMAZ H., Bedir T., Gursoy S., Kaya E., ŞENEL İ., Tinaz G. B., GÜNDÜZ O., ÜSTÜNDAĞ C. B.
    Although different fabrication methods and biomaterials are used in scaffold development, hydrogels and electrospun materials that provide the closest environment to the extracellular matrix have recently attracted considerable interest in tissue engineering applications. However, some of the limitations encountered in the application of these methods alone in scaffold fabrication have increased the tendency to use these methods together. In this study, a bilayer scaffold was developed using 3D-printed gelatin methacryloyl (GelMA) hydrogel containing ciprofloxacin (CIP) and electrospun polycaprolactone (PCL)-collagen (COL) patches. The bilayer scaffolds were characterized in terms of chemical, morphological, mechanical, swelling, and degradation properties; drug release, antibacterial properties, and cytocompatibility of the scaffolds were also studied. In conclusion, bilayer GelMA-CIP/PCL-COL scaffolds, which exhibit sufficient porosity, mechanical strength, and antibacterial properties and also support cell growth, are promising potential substitutes in tissue engineering applications.