Person: DİKPINAR, TUĞÇE
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DİKPINAR
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TUĞÇE
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Publication Metadata only Antimicrobial activities of medicinal plants containing phenolic compounds(Bentham Science Publishers, 2020) DİKPINAR, TUĞÇE; Dikpınar T., Süzgeç-Selçuk S.Background: Medicinal plants have been used to treat diseases for centuries. They are important sources in terms of their pharmacological effects and also have many microbial agents. Recently, the development of drug resistance has begun to spread in human pathogens against used antibiotics and this has led to new research for novel antimicrobial substances from natural products containing plants. Objective: The purpose of this review is to determine the antimicrobial activity of pure phenolic compounds isolated from medicinal plants, to evaluate how molecular structures of these compounds affect the activity, and to provide to the readers a source for future studies on natural antimicrobial agents. Methods: Relevant information was gathered from scientific engines and databases (Google Scholar, Web of Science, Scifinder, Science Direct, Scopus, Wiley Online Library, PubMed, Taylor & Fran-cis online) using different keywords. Antimicrobial activity research was selected especially on pure phenolic compounds. Results: Numerous phenolic compounds were isolated from plants/plant extracts and were shown to prevent the growth of bacteria and fungi and their Minimum Inhibition Concentration (MIC) and inhibition zone values were given in detail. Conclusion: This review revealed that phenolic compounds found in medicinal plants have different antimicrobial activity according to their changes in the molecular structure. © 2020 Bentham Science Publishers.Publication Metadata only LC-MS/MS analysis and biological activities of endemic achillea sieheana stapf from Turkey(2021-09-10) DİKPINAR, TUĞÇE; BİTİŞ, LEYLA; Dikpınar T., Göger F., Bitiş L.Publication Metadata only Phytochemical evaluation of the Ferulago genus and the pharmacological activities of its coumarin constituents(Elsevier GmbH, 2021) DİKPINAR, TUĞÇE; Süzgeç-Selçuk S., Dikpınar T.The genus Ferulago W. Koch is a member of the Apiaceae (Umbelliferae) family and consists of 49 species throughout the world. In traditional medicine, Ferulago species have been utilized as sedatives, carminatives, aphrodisiacs, for increasing milk secretion and for the treatment of bronchitis, skin diseases, and eye diseases. The authors aimed to evaluate the phytochemical constituents of Ferulago species and the pharmacological activities of its coumarins. In this review, literature searches were performed using scientific search engines and databases (Google Scholar, SciFinder, Science Direct, Scopus, PubMed.) for papers published in the past until June 2019. The molecular structures of all isolated compounds are shown in Tables 2, 3, and 4, and the main constituents of the essential oil (Table 5) are indicated with the identified number, characterization, and extraction method. Additionally, the pharmacological activities of the coumarins isolated from the Ferulago genus were investigated. The results demonstrated that coumarins have various pharmacological activities such as antimicrobial, antioxidant, antiproliferative, and anticholinesterase activities. Therefore this review may be considered to be an important scientific resource for future research. © 2020 Elsevier GmbHPublication Open Access LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye(2022-01-01) DİKPINAR, TUĞÇE; BİTİŞ, LEYLA; DİKPINAR T., GÖGER F., BİTİŞ L.© 2022 Marmara University Press.In this study, in vitro ABTS, DPPH, 5-lipoxygenase, and α-glucosidase inhibitory activities of n-hexane (ASH), dichloromethane (ASD), ethyl acetate (ASE), and methanol (ASM) extracts from the aerial parts of endemic A. sieheana were assayed for the first time. The phytochemical content of ASE, the most active extract, has been first determined by LC-MS/MS. Also, the total amount of phenolic compounds of extracts were calculated. ASE demonstrated significant antioxidant activity with IC50 values of 0.096 and 0.156 mg/mL for ABTS and DPPH, respectively. ASD and ASE with IC50 values of 0.045 and 0.089 mg/mL exhibited significant anti-inflammatory activity. ASE showed moderate α-glucosidase inhibitory activity with an IC50 value of 0.774 mg/mL. Also, the total phenolic content was found to be highest in the ASE. Feruloylquinic acid, luteolin, luteolin glucoside, isorhamnetin, isovitexin, methoxyflavonoid like chrysoeriol and its glycoside derivative in the ASE were detected by LC-MS/MS. The results demonstrated that ASE had significant anti-inflammatory, antioxidant and moderate α-glucosidase inhibitory potential.