Person: GÜRBÜZ, BURÇAK
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GÜRBÜZ
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BURÇAK
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Publication Open Access Publication Metadata only Cinsel yolla bulaşan enfeksiyonlar konusunda ne kadar bilgiliyiz(2016-11-05) GÜRBÜZ, BURÇAK; Yeşil S., Gürbüz B.Cinsel yolla bulaĢan enfeksiyonlar (CYBE) sadece geliĢmekte olan ülkelerde değil tüm dünyada insan sağlığını büyük ölçüde tehdit eden baĢlıca sağlık sorunlarından biridir. Toplumların yanlıĢ bilgilendirilmeleri sonucu bu enfeksiyonların sağaltımında güçlükler yaĢanmaktadır. Bu çalıĢmada; Ġstanbul ili Bağcılar 6 no‟lu Aile Sağlığı Merkezi‟nde 2016 yılı mart ve nisan aylarında, gönüllü 87 kiĢiye yüz yüze anket uygulanmıĢ ve CYBE konusunda gönüllülerin bilgi düzeyleri değerlendirilmiĢtir. Anket sorularına verdikleri cevaplar sonucu çalıĢmamıza katılan gönüllülerin % 55.6‟sının CYBE konusunda bilgi sahibi oldukları belirlenmiĢtir. ÇalıĢmamızın sonucuna göre; CYBE ve cinsel sağlık eğitimi konularında eğitim programları geliĢtirilip yaygınlaĢtırılmalı ve böylece toplumun bilgi düzeyinin arttırılması sağlanmalıdır.Publication Open Access Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity(2022-01-01) TOK, FATİH; GÜRBÜZ, BURÇAK; KAYMAKÇIOĞLU, BEDİA; TOK F., Doğan M. O. , GÜRBÜZ B., Koçyiğit-Kaymakçioğlu B.© 2022 Marmara University Press.In this study, new nine pyrazoline derivatives were synthesized from chalcone derivatives. The antimicrobial activity of nine pyrazoline derivatives to four standard bacterial strains (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis) and four standard yeast strains (Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis) was investigated by the microdilution method for in accordance with the Clinical and Laboratory Standards Institute (CLSI) standard, and the Minimal Inhibitory Concentration (MIC) values of these derivatives were determined. Among these derivatives; compounds 7 and 8 against bacterial strains and compounds 2 and 3 against yeast strains exhibited good antimicrobial activity.Publication Metadata only Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture(ELSEVIER, 2007) GÜRBÜZ, BURÇAK; Ugurlu, Timucin; Turkoglu, Murat; Gurer, Umran Soyogul; Akarsu, Burcak GurbuzNisin containing pectin/HPMC compression coated tablets were prepared and their in vitro behavior tested for colonic delivery. Nisin is a 34-amino-acid residue long, heat stable peptide belonging to the group A lantibiotics with wide antimicrobial activity against Grampositive bacteria. The invention can be useful for treating colonic infectious diseases such as by Clostridium difficile, and also by colonization of vancomycin-resistant enterococci. In this study, each 100 mg core tablet of nisin was compression coated with 100% pectin, 90% pectin-10% HPMC, 85% pectin-15% HPMC, 80% pectin-20% HPMC 75% pectin-25% HPMC, 100% HPMC at a coat weight of 400 mg. The concentration and the activity of nisin were quantified using Well Diffusion Agar Assay. Drug release studies were carried out in pH 3.3 buffer solution. System degradation/erosion experiments were carried out in pH 1.2, 3.3, and 6.8 buffers using a pectinolytic enzyme. The biological activity and NMR studies were performed to assess the stability of nisin during the processing and after the in vitro tests. It was found that pectin alone was not sufficient to protect the nisin containing core tablets. At the end of the 6 h 40% degradation was observed for 100% pectin tablets. HPMC addition required to control the solubility of pectin, a 5% increase in HPMC ratio in pectin/HPMC mixture provided a 2-h lag time for nisin release. Eighty percent pectin-20% HPMC appeared to be an optimum combination for further evaluation. Tablets maintained their integrity during the 6-h dissolution test, approximating the colon arrival times. Nisin was found to be active/stable during processing and after in vitro tests. Effect of polymer hydration on pectin degradation was found to be crucial for the enzyme activity. Sufficiently hydrated pectin degraded faster. The pectin/HPMC envelope was found to be a good delivery system for nisin to be delivered to the colon. (c) 2007 Elsevier B.V. All rights reserved.Publication Metadata only Synthesis and antimicrobial evaluation of new pyrazoline derivatives(2022-05-28) GÜRBÜZ, BURÇAK; TOK, FATİH; Tok F., Gürbüz B.Publication Metadata only Bazı Sülfonamid Türevlerinin Standart Bakteri Kökenlerine Karşı Antibakteriyel Etkileri(2020-12-20) GÜRBÜZ, BURÇAK; Gürbüz B., Türkmen C.Publication Open Access Potential Adjuvant Effects of Nigella sativa Seeds to Improve Specific Immunotherapy in Allergic Rhinitis Patients(KARGER, 2010) GÜRBÜZ, BURÇAK; Isik, Huelya; Cevikbas, Adile; Gurer, Umran Soyogul; Kiran, Bayram; Uresin, Yagiz; Rayaman, Pervin; Rayaman, Erkan; Gurbuz, Burcak; Buyukozturk, SunaObjective: To investigate the effects of Nigella sativa seed supplementation on symptom levels, polymorphonuclear leukocyte (PMN) functions, lymphocyte subsets and hematological parameters of allergic rhinitis. Subjects and Methods: Twenty-four patients randomly selected from an experimental group of 31 (mean age 34 years) sensitive to house dust mites with allergic rhinitis and a control group of 8 healthy volunteers (mean age 23 years) were treated with allergen-specific immunotherapy in conventional doses for 30 days. After a month of immunotherapy, 12 of the 24 patients and the 8 healthy volunteers were given N. sativa seed supplementation (2 g/day orally) for 30 days. The remaining 12 patients continued only on immunotherapy during the same period. The other 7 patients were given 0.1 ml saline solution subcutaneously once a week as a placebo. The symptom scores, PMN functions, lymphocyte subsets and other hematological parameters were evaluated before and after all treatment periods. Results: There was a statistically significant increase in the phagocytic and intracellular killing tivities of PMNs of patients receiving specific immunotherapy, especially after the addition of N. sativa seed. The CD8 counts of patients receiving specific immunotherapy plus N. sativa seed supplementation significantly increased compared to patients receiving only specific immunotherapy. PMN functions of healthy volunteers significantly increased after N. sativa seed supplementation compared to baseline. Conclusion: N. sativa seed supplementation during specific immunotherapy of allergic rhinitis may be considered a potential adjuvant therapy. Copyright (C) 2010 S. Karger AG, BaselPublication Metadata only FLAVONOIDS AND BIOLOGICAL ACTIVITIES OF Centaurea stenolepis(SPRINGER, 2014) ŞEN, ALİ; Sen, Ali; Gurbuz, Burcak; Gurer, Umran Soyogul; Bulut, Gizem; Bitis, LeylaPublication Metadata only Investigation of chronotherapeutic effects of amphotericin B administered to mice infected with Candida albicans(TAYLOR & FRANCIS LTD, 2013) GÜRBÜZ, BURÇAK; Tahmaz, Yesim; Cevikbas, Adile; Gurer, Umran Soyogul; Gurbuz, Burcak; Cevikbas, UgurIn this study, mice were infected with Candida albicans at 07:00 h or 19:00 h. After 24 h, the subgroups of mice received either 0.2/ml saline (as control) or one of two doses (0.5 or 1.0 mg/kg) of amphotericin B (AmB) at 0 h or 12 h for three consecutive days. A second set of uninfected mice received a single dose of either saline or AmB (5 mg/kg) at 0 h or 12 h for 4 days to study only about nephrotoxicity. For uninfected controls and AmB-treated (5 mg/kg) mice, serum blood urea nitrogen (BUN), creatinine and total protein tended to be higher at 0 h vs. 12 h, as was the histopathology score in treated mice (3.60 vs. 1.20). Serum levels changed in treated mice when compared to the control mice. The BUN levels increased whereas serum creatinine levels decreased at 12 h compared to 0 h. C. albicans colony forming units per milliliter (CFU/ml) was high in the kidneys of infected mice. Compared with the control, after treatment for 3 days with 0.5 mg AmB lowered CFU by 48% at 0 h and by 75% at 12 h. However, for the higher dose 1.0 mg AmB, CFU was lowered more or less equally at both test times: 51% at 0 h and 46% at 12 h.Publication Metadata only Synergic potential of Pelargonium endlicherianum Fenzl. Essential oil and antibiotic combinations against Klebsiella pneumoniae(ELSEVIER, 2020) GÜRBÜZ, BURÇAK; Dumlupinar, Berrak; Karatoprak, Gokce Seker; Celik, Damla Damar; Gurer, Umran Soyogul; Demirci, Betul; Gurbuz, Burcak; Rayaman, Pervin; Kurtulus, Eda MerveIn this study we investigated antimicrobial activity against Klebsiella pneumoniae and the phagocytic functions of human leukocyte cells as revealed in an in vitro experimental model combining cefepime and gentamicin with Pelargonium endlicherianum Fenzl. essential oil treatments. The bactericidal effects of this essential oil and antibiotic combinations were dynamically detected by time-kill assay. To examine the function of this essential oil and antibiotics in permeating outer membrane barriers when used singly or in combination, a UV spectrophotometer was used, and morphologic images were captured by scanning electron microscopy. The antibacterial activity of the essential oil and antibiotics was assessed using broth microdilution and agar well diffusion. The combined effects of the essential oils of P. endlicherianum and gentamicin and cefepime were evaluated by means of the checkerboard method against K. pneumoniae. In the assays, fractional inhibitory concentration (FIC) values were calculated to characterize the interactions between the combinations. In the combinations of essential oil and antibiotics, the sensitivity of the bacteria to antibiotics increased and the antibiotics had a synergistic effect, and the antibacterial effect on the microorganisms increased. The cefepime + essential oil pair tested showed a synergistic effect (FIC <= 0.5), but the gentamicin + essential oil pair did not (FIC > 0.5-4.0). Thus, the cefepime + essential oil pair has been found to exhibit a synergistic effect against K. pneumoniae compared to the gentamicin + essential oil pair. According to the results obtained here, the combined use of essential oils with antibiotics can be applied as a treatment strategy to reduce the use of antibiotics, reduce side effects, and possibly reverse antibiotic resistance to these microorganisms in light of the increase in multiple antibiotic resistance. (c) 2020 SAAB. Published by Elsevier B.V. All rights reserved.