Person: YOLDEMİR, AHMET TEVFİK
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YOLDEMİR
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AHMET TEVFİK
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Publication Metadata only Importance of genitourinary syndrome of menopause in the quality of life of postmenopausal women(2022-10-27) YOLDEMİR, AHMET TEVFİK; Çevik C. E. , Yoldemir A. T.Publication Metadata only Health promotion for healthy ageing(2021-09-08) YOLDEMİR, AHMET TEVFİK; YOLDEMİR A. T.Publication Metadata only Comparison of anxiety scores between unexplained primary and secondary infertile couples(TAYLOR & FRANCIS LTD, 2021) YOLDEMİR, AHMET TEVFİK; Yoldemir, Tevfik; Yassa, Mahmut; Atasayan, KemalObjective To investigate the anxiety levels among infertile women and their partners also factors that may affect the anxiety status Study design A total of 403 infertile couples who applied to Infertility Outpatient Clinics of a University-affiliated Teaching and Research Hospital were included in the study. The infertile group was divided into two groups as primary and secondary infertile. One hundred and thirty-two fertile couples who applied to Gynecology Outpatient Clinics composed the control group. Hamilton Anxiety Rating Scale (HAM-A) form was filled by the infertile couples to evaluate the anxiety status before they started their treatment. Results Three hundred and twenty infertile and 84 fertile couples completed the study. The mean total scores of HAM-A of women were similar between the groups. So were the scores of their husbands. In all groups, women had significantly higher mean total HAM-A scores than their husbands. There was no association between the mean HAM-A score of women and age, BMI, AFC, duration of marriage, duration of infertility, number of previous treatment cycles. Education status, working status and family structure of women did not correlate with the mean HAM-A score. Conclusion Unexplained primary and secondary infertile couples had similar anxiety scores before the commencement of fertility treatments. However, the scores were higher in women than their male partners. Since the burden of treatment and the likelihood of treatment failure might increase the level of anxiety the women could be offered proper cognitive coping and relaxation interventions.Publication Metadata only Assessment and management of B3 breast lesions with atypia: a focused review(TAYLOR & FRANCIS LTD, 2020) YOLDEMİR, AHMET TEVFİK; Ugurlu, M. U.; Yoldemir, T.; Gulluoglu, B. M.Breast lesions with atypia are a spectra of diseases that confer increased risk of breast cancer because of an increased probability of finding concomitant cancer after excision, or evolution toward in situ or invasive cancer over the long term. The widespread use of radiologic tools and core needle breast biopsies, in recent years, has led to an increase in the diagnosis of these atypical breast lesions. Concurrent with this has been an improvement in the classification and pathogenesis of these lesions. Current evidence suggests that the recognition and treatment of patients with atypical histology after biopsy and surgical excision requires a multidisciplinary approach to decrease the overdiagnosis and overtreatment risks. This focused review investigates the controversy and current management of atypical ductal hyperplasia, lobular neoplasia, flat epithelial atypia, and intraductal papilloma with atypia along with the risk-reducing strategies.Publication Open Access Evaluation and management of endometriosis.(2023-04-13) YOLDEMİR, AHMET TEVFİK; Yoldemir T.The initial diagnostic investigations for endometriosis are physical examination and pelvic ultrasound. The pelvic examination should include a speculum examination and vaginal palpation. Mobility, fixation and/or tenderness of the uterus and site-specific tenderness in the pelvis should be evaluated. Transvaginal ultrasound and pelvic magnetic resonance imaging are recommended to evaluate the extent of the endometriosis and to determine whether any urinary tract or bowel procedures might also be required during surgical resection. Quality of life should be assessed by using the Endometriosis Health Profile-30, its short version EHP-5 or the generic quality of life questionnaire SF- 36. Management of endometriosis is recommended when it has a functional impact (pain, infertility) or causes organ dysfunction. Many gynecological societies have published different guidelines for the evaluation and management of endometriosis. However, the complexity of this disease together with the different available treatments lead to significant discrepancies between the recommendations. Postmenopausal endometriosis should be considered when a patient has a history of symptoms before menopause including dysmenorrhea, dyspareunia, dyschezia, infertility and chronic pelvic pain. Malignant transformation of endometriosis is estimated to occur in about 0.7–1.6% of women affected by endometriosis. Endometriosis is associated with an increased risk of ovarian cancer, specifically clear cell, endometrioid and low-grade serous types.Publication Metadata only Tıbbi müdahalelerde uzmanlık vetki sinirinin değerlendirilmesi: olgu sunumu(2022-11-06) YOLDEMİR, AHMET TEVFİK; Ertaş O. C. , Kalem Y., Yoldemir A. T. , Arıcan N.Publication Metadata only İstemli Düşük ve Yasal Çerçeve(Seçkin Yayıncılık, 2022-01-01) SERT, GÜRKAN; YOLDEMİR, AHMET TEVFİK; SERT G., YOLDEMİR A. T.Publication Metadata only Relation between hot flushes and endothelial dysfunction in postmenopausal women(2021-10-10) YOLDEMİR, AHMET TEVFİK; Çevik C. E., Yoldemir A. T.Objective: To evaluate the relation between hot flushes and endothelial dysfunction in postmenopausal women: Study Design: A study was conducted on total of 132 women, who are between 45-65 years old and applied to Marmara University Pendik Research and Teaching Hospital Outpatient Clinic of Gynaecology, of whom 79 were postmenopausal women and 53 were premenopausal women. Of 132 participants, 32 experience no flushes, 22 mild, 40 moderate, and 38 severe. The demographic, metabolic, and hormonal characteristics were noted and all of the subjects completed within the duration of one week three-category hot flush diary that was conformed to FDA and EMEA guidelines, out of which none, mild, moderate, and severe groups were obtained. Carotid Intima Media Thickness (CIMT) and Flow Mediated Dilatation (FMD) on Brachial Artery measurements were completed on each one of the subject. A prospective case control study was performed. Only 76 Women agreed their blood to be drawn. Results: Mean FMD and CIMT values were similar in premenopausal and postmenopausal women (p=0.06). Blood biochemical values were similar in premenopausal and postmenopausal women. Mean FMD and CIMT values were similar both in the absence and the presence of the hot flushes, regardless of their severity. There was a direct correlation between the presence of the hot flushes, regardless of their severity and the time elapsed since menopause (p=0.001). Mean CIMT, FMD, blood biochemical values were similar both in the absence and the presence of the hot flushes, regardless of their severity. Conclusion: Direct correlation between the severity of hot flushes and the endothelial dysfucntion in postmenopausal was not found. There was a direct correlation between the presence of the hot flushes, regardless of their severity and the time elapsed since menopause (p=0.001).Publication Metadata only The evaluation of ventricular functions by speckle tracking echocardiography in preeclamptic patients(SPRINGER, 2020) YOLDEMİR, AHMET TEVFİK; Paudel, Ashok; Tigen, Kursat; Yoldemir, Tevfik; Guclu, Mehmet; Yildiz, Ipek; Cincin, Altug; Sunbul, Murat; Gurel, Emre; Sayar, Nurten; Ozben, BestePreeclampsia is a maternal disorder of pregnancy characterized by concomitant increase in preload and afterload with end organ dysfunction. The aim of our study is to evaluate left ventricular (LV) and right ventricular (RV) functions with speckle tracking echocardiography in preeclamptic patients. Fifty-five preeclamptic (mean age: 30.7 +/- 5.9 years) and 35 healthy pregnant women (mean age: 28.8 +/- 5.7 years) of the same race, similar age and gestational week were consecutively included. The diagnosis of preeclampsia was based on the criteria proposed by the American College of Obstetricians and Gynecologists. LV and RV functions were assessed by both conventional and speckle tracking echocardiography after the 30th gestational week and at the postpartum 6th months. The preeclamptic patients had significantly larger left atrium, thicker interventricular septum, higher systolic pulmonary artery pressure and mitral E/e ' ratio compared to controls during pregnancy while LV ejection fraction was similar. Preeclamptic patients had significantly lower LV and RV global longitudinal strain (GLS) during pregnancy compared to controls (- 18.0 +/- 2.6% vs. - 19.8 +/- 2.1% p = 0.001 and - 26.7 +/- 3.3% vs. 28.9 +/- 3.3% p = 0.002, respectively). In the postpartum period, while LVGLS values of preeclamptic patients increased significantly (- 18.0 +/- 2.6% vs. - 20.4 +/- 2.4% p < 0.001) and became similar to those of controls at the sixth month, the RVGLS decreased significantly (- 26.7 +/- 3.3% vs. - 25.8 +/- 2.7% p = 0.003) making the difference in RVGLS between the preeclamptic patients and controls more prominent. Preeclampsia may impair LV and RV function. Long-term follow up with larger sample is needed to determine the clinical relevance of the observed changes in strain.Publication Metadata only Uterine ageing(2023-05-04) YOLDEMİR, AHMET TEVFİK; Yoldemir A. T.Studies using animal models, have investigated the influence of increasing age on uterine factors that might lead to abnormal decidualization and reduced implantation and defective placentation. The decidual response to a standardized estrogen /progesterone stimulus was reduced in the older animals; whereas, in young rodents decidual response closely resembled the normal decidual response during implantation. Furthermore in rodents, there was a decrease in the expression of endometrial estrogen and progesterone receptor in older ones. Several microRNAs have been associated with the fibrosis process in mice causing age-related uterine dysfunction. Aging of the uteri lead to the downregulation of several genes associated with cell proliferation in mice, indicating impaired proliferation in the presence of senescent cells.In vitro studies of human endometrial stromal cell proliferation revealed that presence of senescent endometrial stromal cells within the endometrium, as well as senescence-associated secretory phenotype secretion which could disturb normal functional activities such as communication with epithelial and endothelial cells, glands formation, vascularization and immune cells attraction. Human endometrial gene expression studies showed that some gene expressions increased as others decreased with age. Likewise some endometrium functions were either up-regulated or down-regulated after 35 years of age. Similarly some ciliary processes were significantly up-regulated in the endometrium of older women (40 years) while some functions associated with cell cycle/ proliferation were down-regulated.The progesterone-governed endometrial transformation is necessary for implantation. Studies which investigated the influence of endometrial ageing on reproductive outcomes in oocyte donation cycles have controversial results. Some authors showed no influence whereas others reported the age-related decline in implantation and pregnancy rates using euploid embryos or young oocyte donors. Lower implantation and live birth rates with fresh donor oocytes for women over 44 years of age were reported when compared to younger recipients. High doses of progesterone could compensate for the abnormal receptivity of aged recipients during oocyte donation. Moreover maternal age over 40 years was associated with a further increase in risk for placental abruption, preterm delivery, low birthweight, intrauterine growth restriction, stillbirth, and perinatal mortality.