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FİLİNTE, DENİZ

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FİLİNTE

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2019 - 20202
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Author: ARIKAN, İZZET HAKKI × Has files: true ×

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    PublicationOpen Access
    The Intensity of PLA2R and C4d_x000D_ Immunoexpression in Primary_x000D_ Membranous Nephropathy
    (2019) FİLİNTE, DENİZ; Deniz FİLİNTE;Hakkı ARIKAN;Mehmet KOÇ;Handan KAYA;İshak Çetin ÖZENER;Gamze AKBAŞ
    Objective: Antibodies against the phospholipase A2 receptor (PLA2R) on podocyte membranes result in the formation of immune complexes that cause loss of function of theglomerular basement membrane in primary membranous nephropathy (PMN). It has alsobeen demonstrated that there is a deposition of complement 4d (C4d) in the glomeruli inPMN. The present study aims to evaluate PLA2R and C4d immunoexpressions in PMN casesand search the correlation with the clinical parameters.Methods: In this study, clinicopathological data and paraffin-embedded specimens werecollected from 51 patients. The formalin-fixed paraffin-embedded tissues were stained usingroutine hematoxylin-eosin, periodic acid-Schiff, and silver methenamine stains and immunostained for anti-PLA2R and C4d. Ten normal kidney tissues and 10 focal segmental glomerulosclerosis (FSGS) cases were selected as controls for PLA2R and C4d immunoexpression.Results: Of the PMN cases, 51 (100%) cases were positive for PLA2R, including 15 (29%)cases that scored 2+, and 36 (71%) cases that scored 3+. Forty of the 51 cases (78%) werepositive for C4d. The percentages of cases staining positively for C4d, per scoring group,were as follows: 31 (61%) cases faintly (1+) positive and 9 (18%) cases moderately (2+)positive. No strong positivity was observed. All of the control cases (100%) were negativefor PLA2R and C4d. There was no statistically significant difference between the intensity ofthe staining of PLA2R and the staining of C4d, proteinuria levels, creatinine levels, and complement 3 (C3) positivity. Similarly, there was no statistically significant difference betweenthe intensity of the staining of C4d and proteinuria levels, creatinine levels, and C3 positivity.Conclusion: Immunohistochemical detection of PLA2R and C4d is a safe and easy methodfor the diagnosis of PMN. In cases where fresh tissue is not available for the detection of IgGand C3 using the immunofluorescence method, positivity for PLA2R and C4d with immunohistochemistry may be beneficial for the diagnosis of PMN.
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    PublicationOpen Access
    Renal Amyloidosis Secondary to Dystrophic Epidermolysis Bullosa: A Case Report and Review of Literature
    (2020-10-20) VELİOĞLU, ARZU; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Barutcu Atas, Dilek; Aykent, Mahmut Basar; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Arikan, Izzet Hakki; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Asicioglu, Ebru; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Velioglu, Arzu; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Filinte, Deniz; Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey; Koc, Mehmet; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Serhan Tuglular, Zubeyde; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Ozener, Ishak Cetin; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey