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SAZAK ÖVEÇOĞLU, HESNA

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SAZAK ÖVEÇOĞLU

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2019 - 201912020 - 20232
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    PublicationOpen Access
    Devital beyazlatma uygulamalarının bağlantı ve mikrosızıntıya etkisi
    (2021-04-01) ÖZDEN, İDİL; SAZAK ÖVEÇOĞLU, HESNA; Özden İ., Sazak Öveçoğlu H.
    Kanal tedavisini takiben yapılan restorasyon, kanal tedavisinin başarısını etkileyen önemli bir faktördür. Kalan diş dokusunu desteklemeleri, koronal sızıntıyı önleyerek kök kanal sisteminin kontamine olmasını engellemeleri ve dişin fonksiyon görmesini sağlamaları gibi özellikler bu restorasyonlarda olması gereken kriterler olarak listelenebilir. Devital dişlerin beyazlatılması da estetik bir gereksinimdir. Devital dişlerin beyazlatılmasında hidrojen peroksit, karbamid peroksit ve sodyum perborat gibi peroksit salan maddeler kullanılmaktadır. Bu bileşiklerin oksidasyon sonucu açığa çıkardığı serbest radikallerin dentin yapısında ve fiziksel özelliklerinde değişikliklere neden olarak bağlantı kuvvetini olumsuz etkilediği bilinmektedir. Serbest radikallerin bağlantı üzerindeki olumsuz etkilerini azaltabilmek için beyazlatma işleminden sonra antioksidan uygulanması veya daimi restorasyonun yapımının beyazlatma işleminden 1-2 hafta sonrasına ertelenmesi literatürde önerilen yöntemlerdendir. Devital dişlerde yapılan beyazlatma uygulamalarından sonra görülebilecek bir diğer komplikasyon ise “kök rezorpsiyonu”dur. Kök rezorpsiyonunun önlenmesi için işlem öncesi mine sement sınırına bariyer uygulaması veya kalsiyum hidroksit ile ortam pH’ının dengelenmesi önerilmiştir. Bu derlemede; kök kanal tedavisinin başarısı üzerinde etkili olabileceği düşünülen devital dişlerde beyazlatma uygulamalarının, kanalüstü bariyerden kanal içine mikrosızıntıya ve restorasyon-dentin bağı dayanımına olan etkisi anlatılmaktadır.
  • Thumbnail Image
    PublicationOpen Access
    Treatment of maxillary central incisors with internal resorption: Two case reports
    (2019-04-01) TÜRKAYDIN, DİLEK; İRİBOZ, EMRE; SAZAK ÖVEÇOĞLU, HESNA; Karakaya G., Can G., Türkaydın D., İriboz E., Sazak Öveçoğlu H.
    Internal root resorption is a rare condition, but it may require complex treatment protocols, depending on the progression. The aim of this case report is to present the treatment protocol and the follow-up results for 2 cases of a right upper central incisor with internal root resorption. A 15-year-old female patient presented with the chief complaint of dental caries. The radiological examination revealed that tooth #21 had internal resorption (IR) in the middle third of the root. The warm vertical condensation technique was applied using a warm obturation system. At 3 years, the tooth was asymptomatic and no lesions were observed. A 48-year-old female patient was referred to the clinic for a routine control. The radiological examination revealed IR in the middle third of tooth #21. As the resorption area was quite wide, cone beam computed tomography was used. The results indicated that there was also external resorption in the buccal part of the root. Therefore, the treatment protocol was changed and the IR area was sealed with mineral trioxide aggregate. At 1 year, the tooth was asymptomatic and no lesions were observed. Keywords: Cone beam computed tomography; internal root resorption; mineral trioxide aggregate; root perforation; trauma.
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    PublicationOpen Access
    TNF-α, IL-1B and IL-6 affect the differentiation ability of dental pulp stem cells
    (2023-12-01) SAZAK ÖVEÇOĞLU, HESNA; AKKOÇ, TUNÇ; Sonmez Kaplan S., SAZAK ÖVEÇOĞLU H., Genc D., AKKOÇ T.
    Background: This in vitro study examined the effect of the inflammatory cytokines (tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6) on osteogenic, chondrogenic, and adipogenic differentiation of dental pulp stem cells (DPSCs) which have significant relevance in future regenerative therapies. Methods: DPSCs were isolated from the impacted third molar dental pulp and determined with flow cytometry analysis. DPSCs were divided into into 5 main groups with 3 subdivisions for each group making a total of 15 groups. Experimental groups were stimulated with TNF-α, IL-1β, IL-6, and a combination of all three to undergo osteogenic, chondrogenic, and adipogenic differentiation protocols. Next, the differentiation of each group was examined with different staining procedures under a light microscope. Histological analysis of osteogenic, chondrogenic, and adipogenic differentiated pellets was assessed using a modified Bern score. Statistical significance determined using one-way analysis of variance, and correlations were assessed using Pearson’s test (two-tailed). Results: Stimulation with inflammatory cytokines significantly inhibited the osteogenic, chondrogenic and adipogenic differentiation of DPSCs in terms of matrix and cell formation resulting in weak staining than the unstimulated groups with inflammatory cytokines. On contrary, the unstimulated groups of MSCs have shown to be highly proliferative ability in terms of osteogenic, chondrogenic, and adipogenic differentiation. Conclusions: DPSCs have high osteogenic, chondrogenic, and adipogenic differentiation capabilities. Pretreatment with inflammatory cytokines decreases the differentiation ability in vitro, thus inhibiting tissue formation.