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ERCAN, FERİHA

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FERİHA

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End date: 2009 × Has files: true ×

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    PublicationOpen Access
    Grape seed extract treatment reduces hepatic ischemia-reperfusion injury in rats
    (JOHN WILEY & SONS LTD, 2008-01) DULUNDU, ENDER; Sehirli, Ozer; Ozel, Yahya; Dulundu, Ender; Topaloglu, Umit; Ercan, Feriha; Sener, Goksel
    This study was designed to determine the possible protective effect of grape seed extract (GSE), a widely used antioxidant dietary supplement, on hepatic ischemia/reperfusion (I/R) injury. Wistar albino rats were subjected to 45 min of hepatic ischemia, followed by a 60 min reperfusion period. GSE was administered in a dose of 50 mg/kg/day orally for 15 days before (I/R) injury and repeated before the reperfusion period. Liver samples were taken for histological examination or determination of hepatic malondialdehyde (MDA), glutathione (GSH) and myeloperoxidase (MPO) activity. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were determined to assess liver functions. Lactate dehydrogenase (LDH) and cytokines (TNF-alpha and IL-1 beta) were also assayed in serum samples for the evaluation of generalized tissue damage. Ischemia/reperfusion caused a significant decrease in hepatic GSH, and significant increases in MDA level, and MPO activity. Serum AST and ALT levels, as well as LDH activity and plasma TNF-alpha and IL-1 beta levels were also elevated in the I/R group. Treatment with GSE reversed all these biochemical parameters as well as histological alterations induced by I/R. In conclusion, GSE reduced I/R-induced organ injury through its ability to balance the oxidant-antioxidant status, to inhibit neutrophil infiltration and to regulate the release of inflammatory mediators. Copyright (c) 2007 John Wiley & Sons, Ltd.
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    PublicationOpen Access
    Effect of nikel on growth and ultrastructure of Schizosaccaromyces pombe
    (TAYLOR & FRANCIS LTD, 2001-01) ERCAN, FERİHA; Sarikaya, AT; Gunel, T; Arda, N; San, T; Ercan, F; Akman, G; Temizkan, G
    In this project, we investigated effects of nickel (Ni) on the growth and ultrastructure of Schizosaccharomyces pombe wild type strain. It was found that cells were tolerant against a concentration of 2 mM Ni+2 but the generation time was extended to 5 hours from 2.5 hours for the cells growing in Ni-free YEP medium. 76% of Ni+2 was removed in 30 min by the cells grown in YEP containing 1mM Ni+2. We also analyzed the ultrastructural modifications of the cells grown in 1 mM Ni+2. There was a visible thickening of the cell wall and increase in the number of small cytoplasmic vesicles. The plasma membrane appeared irregular compared to smoother contour in control. Vacuoles contained large amounts of electron-dense materials and the size of vacuoles also increased.
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    PublicationOpen Access
    Colitis-induced oxidative damage of the colon and skeletal muscle is ameliorated by regular exercise in rats: the anxiolytic role of exercise
    (WILEY, 2006-09-01) YEGEN, BERRAK; Kasimay, Ozgur; Guzel, Esra; Gemici, Ali; Abdyli, Asead; Sulovari, Admir; Ercan, Feriha; Yegen, Berrak C.
    Epidemiological studies have shown that exercise protects the gastrointestinal tract, reducing the risk of diverticulosis, gastrointestinal haemorrhage and inflammatory bowel disease, while many digestive complaints occurring during exercise are attributed to the adverse effects of exercise on the colon. In order to assess the effects of regular exercise on the pathogenesis of colitis, Sprague-Dawley rats of both sexes were either kept sedentary or given exercise on a running wheel (0.4 km h(-1), 30 min for 3 days week(-1)). At the end of 6 weeks, under anaesthesia, either saline or acetic acid (4%, 1 ml) was given intracolonically. Holeboard tests were performed for the evaluation of anxiety at 24 h before and 48 h after induction of colitis. Increased 'freezing time' in the colitis-induced sedentary group, representing increased anxiety, was reduced in the exercised colitis group (P < 0.05). On the third day following the colonic instillation, the rats were decapitated under brief ether anesthesia and the distal 8 cm of the colons were removed. In the sedentary colitis group, macroscopic and microscopic damage scores, malondialdehyde level and myeloperoxidase activity were increased when compared to the control group (P < 0.01-0.001), while exercise prior to colitis reduced all the measurements with respect to sedentary colitis group (P < 0.05-0.001). The results demonstrate that low-intensity, repetitive exercise protects against oxidative colonic injury, and that this appears to involve the anxiolytic effect of exercise, suggesting that exercise may have a therapeutic value in reducing stress-related exacerbation of colitis.