Person:
OLGUN YILDIZELİ, ŞEHNAZ

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

OLGUN YILDIZELİ

First Name

ŞEHNAZ

Name

Filters

2016 - 201942020 - 20212
Reset filters

Settings

Author: CEYHAN, BERRİN × Has files: true ×

Search Results

Now showing 1 - 6 of 6
  • Thumbnail Image
    PublicationOpen Access
    Extranodal pulmonary marginal zone B-cell lymphoma
    (ELSEVIER SCIENCE BV, 2016) CEYHAN, BERRİN; Yildizeli, Sehnaz Olgun; Eryuksel, Emel; Abul, Yasin; Golabi, Pegah; Kaygusuz, Isik; Kodalli, Nihat; Ahiskali, Rengin; Ceyhan, Berrin
    Aim: Extranodal mucosa-associated lymphoid tissue (MALT) arises a number of epithelial tissues, including the stomach, salivary gland, lung, small bowel, and elsewhere. Here we present a male patient with an uncommon site of extranodal MALT such as a pelvic mass diagnosed after a long period of evaluation, which initially presented with an incidental pulmonary nodule. Method: We report a 60 years old man presenting with pulmonary nodules and consolidation. He refused invasive procedures and 3 years later was administered to our clinic with disseminated pulmonary nodules on chest X-ray. Subsequently a thin needle aspiration biopsy was performed and candida geotrichum was suspected in the specimen of the lung biopsy by light microscopic examination. After this time the patient was referred to our clinic, bronchoscopy, mediastinoscopy and abdominal computerized tomography (CT) scans were performed. Results: Lymphoid hyperplasia was seen in the mediastinal lymph nodes biopsy specimens and the pelvic mass (52 x 18 mm) on the superior iliac muscles not related to any organs. Thin needle biopsy revealed MALT lymphoma and pathological examination of pulmonary nodule was similar to pelvic mass (MALT lymphoma). After the diagnosis, the thin needle biopsy of lung was repeated. The specimen appeared to be similar to the pelvic mass (MALT lymphoma) in the pathologic examination. The patient survived 5 years after initial diagnosis. Conclusion: MALT has an affinity for the different tissues however has not been located in the pelvis. Our case represent an unusual presentation in a 60 years old man with lung and a pelvic mass. (C) 2016 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
  • Thumbnail Image
    PublicationOpen Access
    Anxiety and depression in patients with chronic obstructive pulmonary disease and their relation to serum vitamin D levels
    (MARMARA UNIV, FAC MEDICINE, 2018-02-26) CEYHAN, BERRİN; Kocakaya, Derya; Olgun Yildizeli, Sehnaz; Kocakaya, Ozan; Arikan, Huseyin; Eryuksel, Emel; Ceyhan, Berrin
    Objectives: To determine whether serum vitamin D levels were related to the risk of anxiety and depression among patients with chronic obstructive pulmonary disease (COPD), as well as their spirometry parameters, disease severity, and other clinical findings. Materials and Methods: Ninety-two stable patients with COPD aged over 18 years with no exacerbations in the previous month were included. Symptom severity was assessed using the modified Medical Research Council (mMRC) dyspnea scale and COPD Assessment Test (CAT) scores. Spirometry tests were performed and previous hospitalization histories were recorded to determine ABCD groups of the patients according to their combined COPD assessments. Their Body mass index, airflow Obstruction, Dyspnea and Exercise capacity (BODE) indices were calculated and the Hospital Anxiety and Depression Scale (HADS) was administered. Serum vitamin D levels were determined using immune electrochemiluminescence. Results: According to the HADS scores, 16 patients (17.4%) had the risk of anxiety and 29 (31.5%) had the risk of depression. The risk of anxiety differed significantly (P=0.016 Fischer's exact test) between the ABCD groups. Anxiety scores were positively correlated with both mMRC (r=0.315; P=0.002) and CAT (r=0.445; P=0.000) scores. Similarly, depression scores correlated positively with mMRC (r= 0.249; P=0.017) and CAT (r=0.373; P=0.000) scores. Neither anxiety nor depression scores were significantly correlated with % of predicted FEV1. Serum vitamin D levels were inversely correlated with anxiety (r=-0.215; P=0.039) and depression (r=-0.244; P=0.019) scores. Anxiety scores were positively correlated with BODE although not statistically significantly (r=0.199; P=0.058). Conclusion: A negative correlation was revealed between serum vitamin D levels and HADS scores, and symptom scores were positively correlated to HADS scores, independent of % of predicted FEV1.
  • Thumbnail Image
    PublicationOpen Access
    Procalcitonin-Guided Antibiotic Treatment in Lower Respiratory Tract Infections
    (GALENOS YAYINCILIK, 2018-08-06) CEYHAN, BERRİN; Balci, Merih Kalamanoglu; Balcan, Baran; Yildizeli, Sehnaz Olgun; Ceyhan, Berrin
    Objective: Procalcitonin (PCT), C-reactive protein (CRP), and leukocyte count are important host response biomarkers to determine the presence of infection. The aim of the present study was to evaluate the usefulness of PCT with other markers in lower respiratory tract infections. Methods: A total of 78 patients with community-acquired pneumonia (CAP), chronic obstructive pulmonary disease (COPD) exacerbations, and healthy controls were evaluated. Baseline serum levels of PCT and CRP and leukocyte counts were assessed and repeated on day 7 of antibiotic treatment. Results: Procalcitonin levels and absolute neutrophil counts (ANCs) were higher in the CAP and COPD groups than in the control group. In the CAP and COPD exacerbation groups, the leukocyte count, ANC, and CRP and PCT levels decreased on day 7 of the treatment (p<0.001). In the CAP group, the baseline PCT levels were correlated with leukocyte counts (r=0.495, p<0.005), ANCs (r=0.426, p<0.019), and CRP levels (r=0.515, p<0.004). In receiver operating characteristic curve analysis, PCT threshold >0.12 ng/mL had a sensitivity of 70.4% and specificity of 68.7%, and CRP threshold >22.9 mg/L had a sensitivity of 85.2% and specificity of 75.0%. Conclusion: Procalcitonin is a useful marker to determine the initiation of antibiotic therapy and can also be used to cease the treatment.
  • Thumbnail Image
    PublicationOpen Access
    Prolonged Methylprednisolone Therapy in the Fibro-Proliferative Phase of Acute Respiratory Distress Syndrome
    (CUREUS INC, 2021-11-25) CEYHAN, BERRİN; Kocakaya, Derya; Yildizeli, Sehnaz Olgun; Ataizi-Celikel, Cigdem; Ceyhan, Berrin
    Late-stage acute respiratory distress syndrome (ARDS), primarily associated with fibro-proliferative changes, may occur in many patients. This stage, where ARDS progresses to the point of being incurable, involves a complicated and long clinical course that may give rise to functional loss; it has therefore been a major focus of both preventive and therapeutic strategies. In the present case report, the successful use of prolonged methylprednisolone therapy in the fibre-proliferative phase of ARDS is described in a patient who developed pneumonia and secondary ARDS after terminating a pregnancy due to preeclampsia. Methylprednisolone therapy, which was initiated at a daily dosage of 1mg/kg, was tapered down based on the clinical and radiologic status of the patient and was terminated at the end of the sixth month. Follow-up imaging studies and pulmonary function tests performed at the end of the first and sixth months showed marked improvements and the patient experienced no systemic adverse effects despite long-term steroid therapy.
  • Thumbnail Image
    PublicationOpen Access
    Influence of rosuvastatin treatment on airway inflammatory markers and health related quality of life domains in asthmatic patients
    (MARMARA UNIV, FAC MEDICINE, 2017-05-14) CEYHAN, BERRİN; Olgun Yildizeli, Sehnaz; Kocakaya, Derya; Balcan, Baran; Ikinci, Aygun; Ahiskali, Rengin; Ceyhan, Berrin
    Objectives: Statins are lipid lowering agents which have pleiotropic and anti-inflammatory effects. Beneficial effects of statins have been shown in many inflammatory and asthmatic diseases. However, the results are still not consistent. The aim of this study is to determine the clinical and anti-inflammatory effects of rosuvastatin in asthmatic patients. Patients and Metods: A case control study among asthmatic patients was conducted. One hundred and thirty-six participants were screened. Seventy-four patients were eligible. Fifty-one patients have completed the trial. Twenty-five patients with blood levels of low-density-lipoprotein (LDL) above 130mg/dL, were treated with rosuvastatin 40mg for 8 weeks in addition to their standard treatment for asthma; 26 asthmatic patients were followed as control group. In both groups baseline and 8th week evaluation were recorded including pulmonary function test (PFT), bronchial provocation test (PD20), induced sputum and serum inflammatory markers, asthma control test (ACT) and quality of life scores (QoL). Results: Statin group showed improvement in FEV1/FVC (pp) (85.8 +/- 11.1% vs 90.2 +/- 8.8% P<0.043), FEF 25-75 % (63.6 +/- 7.8 % vs 74.6 +/- 8.4 %, P<0.0001) and FEF25-75(L/sc) (3.51 +/- 0.4 vs 4.1 +/- 0.4 P<0.05) and no change was seen in non-statin group (P>0.05) at the end of the 8-week treatment. Treatment with rosuvastatin resulted in decreased sputum eosinophilia percentage (P<0.05); IL-6 and TNFalpha levels (P<0.05) however, bronchial challenge test, ACT and QoL domains did not change in both groups (P>0.05). Conclusion: An 8-week treatment with 40mg rosuvastatin in asthma decreased the peripheral eosinophilia, total IgE levels and inflammatory markers in the induced sputum samples. Beneficial effects in PFT have also been observed. However, ACT and QoL domains were not affected. The implication of this study is that rosuvastatin could potentially have anti-inflammatory effects on asthmatic airways. Prospective randomised trials to evalute the clinical effects of rosuvastatin are warranted.
  • Thumbnail Image
    PublicationOpen Access
    Sigara bırakma polikliniğine başvuran bireylerde tedavi başarısını etkileyen faktörler
    (2021-01-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ÖZAYDIN, AYŞE NİLÜFER; CEYHAN, BERRİN; KOCAKAYA D., ŞENOL H., ASLAN S., ÇIRAKOĞLU A. M., ÇAKIR FİDAN M. N., TELCİ H., ÇETİNKAYA M. Z., OLGUN YILDIZELİ Ş., ÖZAYDIN A. N., CEYHAN B.
    Amaç: Sigara içme davranışının devam etmesinde ve tedavi girişimlerinin başarısız olmasında, nikotin bağımlılığının birinci neden olduğu belirtilmekte olup nikotin bağımlılığını etkileyen birçok faktör bulunmaktadır. Bu araştırmanın amacı, 18 yaş ve üzerindeki sigara bağımlılarının, sigara bırakma başarılarında hangi faktörlerin daha etkili olduğunu belirlemektir. Yöntem: Retrospektif kohort tipindeki araştırmamızda, sigara bırakma polikliniğimize başvurmuş olan bireyler telefon ile aranmış ve sözlü onamlarının alınmasını takiben anket formumuzdaki sorular ile değerlendirilmiştir. Bulgular: Çalışmamıza katılan 190 bireyin %32,1’i kadın (n=61), %67,9’u erkek (n=129) olup medyan yaş 39,5 (çeyrekler arası aralık:19, min:19 - max:78) olarak bulunmuştur. Erkeklerin %32,6’sının (n=42), kadınların ise %14,8’inin (n=9) sigara bırakmada başarılı olabildiği saptandı. Elli yaş üzeri bireylerin %38,8’i (n=19) sigara bırakmayı başarırken, 50 yaş altındakilerde bu oran %22,7 (n=32) idi. Ayrıca sigara içmeye 15 yaş ve sonrasında başlamış bireylerin sigarayı bırakmadaki başarısı, daha erken yaşta başlayanlara göre daha yüksekti (%31,1). Tedaviye düzenli devam edenlerin, düzenli devam etmeyenlere oranla sigarayı bırakmada daha başarılı olduğu görüldü (%53,8). Erkeklerde sigara bırakma başarısının, kadınlara göre 3,86 kat (GA:1,65-9,03) daha yüksek olduğu; sigaraya geç başlamanın (≥15yaş) erken başlamaya göre sigarayı bırakmayı 5,33 kat (GA:1,69–16,75); tedaviye düzenli devam etmenin ise düzenli devam etmemeye göre sigara bırakmayı 4,31 kat (GA:1,72-10,79) artırdığı bulunmuştur. Sonuç: Erkeklerde daha yüksek olan sigara bırakma başarısının, sigaraya daha geç yaşta başlayanlarda ve tedaviye düzenli devam edenlerde anlamlı derecede arttığı bulunmuştur. Sigara bırakma başarısının halen düşük olduğu ülkemizde, sigara bağımlılığını azaltmak için önemli yapılanmalar olan sigara bırakma polikliniklerinin devamlılığının sağlanması önem taşımaktadır.