Person: OLGUN YILDIZELİ, ŞEHNAZ
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OLGUN YILDIZELİ
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ŞEHNAZ
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Publication Metadata only Parenchymal density changes in acute pulmonary embolism: Can quantitative CT be a diagnostic tool? A preliminary study(ELSEVIER SCIENCE INC, 2017) ÇİMŞİT, NURİ ÇAGATAY; Duman, Ikram Eda; Cimsit, Canan; Yildizeli, Sehnaz Olgun; Cimsit, Nuri CagatayPurpose: Determine the ability of quantitative CT (QCT) in defining parenchymal density changes in acute pulmonary embolism (PE). Material & methods: Mean lung density (MLD) and percentage distribution values (PDV) were calculated in 34 patients suspected of PE using software application based on computerized volumetric anatomical segmentation. Results: Total, left, and right MLD differed significantly between emboli positive(n = 23) and negative(n = 11) groups(p < 0.006, p < 0.009, p < 0.014). PDVs differed between groups (p < 0.05) except for LUZ and RLZ. When PE was present in lobe &/segment branches, PDVs were significantly lower except RUZ. Conclusion: QCT is a promising application for defining parenchymal density changes in PE revealing potential functional impact of emboli. This preliminary study suggests QCT could provide added value to CTPA in peripheral PE. (C) 2016 Elsevier Inc. All rights reserved.Publication Metadata only Incidence and treatment results of laryngopharyngeal reflux in chronic obstructive pulmonary disease(SPRINGER, 2009) OLGUN YILDIZELİ, ŞEHNAZ; Eryuksel, Emel; Dogan, Muzeyyen; Olgun, Sehnaz; Kocak, Ismail; Celikel, TurgayLaryngopharyngeal reflux (LPR) is defined as the movement of gastric content towards the larynx and the pharynx and it may cause respiratory symptoms or difficulty in their control. We aimed to find the frequency of LPR in chronic obstructive pulmonary disease (COPD) patients and to investigate its effect on COPD symptoms and the results of its treatment. At baseline 30 (20 male, 10 female, mean age: 65 +/- A 10 years) COPD patients completed LPR and COPD symptom questionnaires and 13 (44%) were diagnosed with LPR based on laryngeal examination. Patients with LPR were given 2 months of PPI treatment, after which LPR and COPD symptom questionnaires, laryngeal examinations and pulmonary function tests were repeated. Following the treatment, significant improvements in COPD symptom index, LPR symptom index and laryngeal examination findings were observed in patients with LPR (P < 0.01, P < 0.01, P < 0.0001, respectively). Treatment of LPR resulted in a significant improvement in the symptoms of COPD.Publication Metadata only İlerı ve son evre akciğer hastalığına ikincil solunum yetmezliği olan hastaların bakım verenlerinde bakım verici yükü ve depresyon ilişkisi(2018-04-18) OLGUN YILDIZELİ, ŞEHNAZ; KASAPOĞLU, UMUT SABRİ; KOCAKAYA, DERYA; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; KARAKURT, SAİT; ARIKAN, HÜSEYİN; OLGUN YILDIZELİ Ş., ARIKAN H., KASAPOĞLU U. S., KOCAKAYA D., ERYÜKSEL S. E., CEYHAN B., KARAKURT S.Publication Metadata only Protective effect of cysteinyl leukotriene receptor antagonist montelukast in bleomycin-induced pulmonary fibrosis(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2018) CEYHAN, BERRİN; Topaloglu, Nurhayat; Yildizeli, Sehnaz Olgun; Sener, Goksel; Lacin, Tunc; Sehirli, Ozer; Bozkurtlar, Emine; Celikel, Cigdem; Ceyhan, BerrinBackground: This study aims to investigate the early- and late-term effects of pharmacological inhibition of cysteinyl leukotriene activity by using montelukast in bleomycin-induced inflammatory and oxidative lung injury in an animal model. Methods: The study included 48 male Wistar albino rats (weighing 250 g to 300 g). Rats were administered intratracheal bleomycin or saline and assigned into groups to receive montelukast or saline. Bronchoalveolar lavage fluid and lung tissue samples were collected four and 15 days after bleomycin administration. Results: Bleomycin resulted in significant increases in tumor necrosis factor-alpha levels (4.0 +/- 1.4 pg/mL in controls vs. 44.1 +/- 14.5 pg/mL in early-term vs. 30.3 +/- 5.7 pg/mL in late-term, p<0.001 and p<0.001, respectively), transforming growth factor beta 1 levels (28.6 +/- 6.6 pg/mL vs. 82.3 +/- 14.1 pg/mL in early-term vs. 60.1 +/- 2.9 pg/mL in late-term, p<0.001 and p<0.001, respectively), and fibrosis score (1.85 +/- 0.89 in early-term vs. 5.60 +/- 1.14 in late-term, p<0.001 and p<0.01, respectively). In bleomycin exposed rats, collagen content increased only in the late-term (15.3 +/- 3.0 mu g/mg in controls vs. 29.6 +/- 9.1 mu g/mg in late-term, p<0.001). Montelukast treatment reversed all these biochemical indices as well as histopathological alterations induced by bleomycin. Conclusion: Montelukast attenuates bleomycin-induced inflammatory and oxidative lung injury and prevents lung collagen deposition and fibrotic response. Thus, cysteinyl leukotriene receptor antagonists might be regarded as new therapeutic agents for idiopathic pulmonary fibrosis.Publication Metadata only Eri̇şki̇n ki̇sti̇k fi̇brozi̇s hastalarinda İlaç uyumu ve anksi̇yete/depresyonu etki̇leyen faktörler(2018-05-18) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; USLU N. Z. , KOCAKAYA D., OLGUN YILDIZELİ Ş., CEYHAN B.Publication Metadata only Clinical Experience Receiving ECMO for Acute Respiratory Distress Syndrome(AVES, 2017) AK, KORAY; Eryuksel, Emel; Yalcin, Aslihan; Guven, Pinar; Turan, Can; Yildizeli, Sehnaz Olgun; Ispir, Selim; Ak, Koray; Karakurt, SaitAcute respiratory distress syndrome (ARDS) is characterized by pulmonary edema caused by sudden increase in alveolocapillary membrane permeability, hypoxemia, and bilateral lung infiltration. Despite improvement in ICU treatment modalities, the mortality rate among ARDS patients is still considerably high. In the treatment of ARDS, in addition to the treatment of underlying cause, low-tidal volume, lung-protective mechanical ventilation is recommended. However, in patients who cannot attain target oxygen level or develop high plateau pressure despite low-tidal volume ventilation and who cannot tolerate high carbon dioxide and low pH levels, extracorporeal membrane oxygenation (ECMO) may be considered as a good treatment option. In this article, cases of ARDS patients treated with ECMO in our clinic during 2013-14 have been retrospectively documented and discussed in line with the literature.Publication Metadata only Endobronchial coils in treatment of advanced emphysema: A single center experience(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2019) BOSTANCI, KORKUT; Bostanci, Korkut; Bilgi, Zeynep; Omercikoglu, Hakan; Cetinkaya, Cagatay; Yildizeli, Sehnaz Olgun; Yuksel, Mustafa; Stamenovic, DavorBackground: This study aims to present our experience with endobronchial coils in patients who underwent endobronchial lung volume reduction due to advanced emphysema. Methods: The study included 46 patients (45 males, 1 female; mean age 61.7 +/- 8 years; range, 43 to 80 years) who underwent endobronchial lung volume reduction with endobronchial coils for advanced emphysema. Patients' age, gender, pulmonary function tests, post-treatment morbidity, mortality, pre- and post-treatment (6 months) six-minute walking distance, modified Medical Research Council dyspnea scores, chronic obstructive pulmonary disease assessment test and Hospital Anxiety and Depression Scale scores were recorded. Results: Patients had an average of 65 pack/year smoking history. An average of 11 (range, 9-15) coils were placed per lobe (right upper lobe=35, left upper lobe=19, right lower lobe=2, left lower lobe=4). Mean follow-up duration was 12.6 months (+/- 5.6 months). Post-treatment forced expiratory volume in one second, residual volume and six-minute walking distance values were improved with statistical significance. Also, significant improvement was seen in quality of life, quantified by modified Medical Research Council, chronic obstructive pulmonary disease assessment test and Hospital Anxiety and Depression Scale scores. While no immediate major postoperative complications occurred, three patients developed chronic obstructive pulmonary disease exacerbation, two developed pneumonia, and one developed recurrence of previous neurologic disorder within 30 days. Conclusion: Endobronchial coil administration provides lower morbidity and mortality compared to lung volume reduction surgery as well as significant improvement in pulmonary functions and quality of life in selected patients with advanced emphysema.Publication Metadata only Approach of pulmonologists in Turkey to noninvasive mechanical ventilation use in acute respiratory failure(TURKISH ASSOC TUBERCULOSIS & THORAX, 2015) OLGUN YILDIZELİ, ŞEHNAZ; Ugurlu, Aylin Ozsancak; Ergan, Begum; Takir, Huriye Berk; In, Erdal; Ozyilmaz, Ezgi; Edipoglu, Ozlem Ertan; Acarturk, Eylem; Balbay, Ege Gulec; Dilektasli, Asli Gorek; Kivanc, Tulay; Ekren, Pervin Korkmaz; Ulasli, Sevinc Sarinc; Dogrul, Ilgaz; Ucar, Elif Yilmazel; Olgun, Sehnaz; Devran, Ozkan; Ergun, Recai; Karakurt, ZuhalIntroduction: Noninvasive mechanical ventilation (NIV) has been increasingly used worldwide for acute respiratory failure (ARF), especially in patients with chronic lung disorders. We aimed to define the approach of pulmonologists in Turkey to NIV use for ARF management. Materials and Methods: A 38-question survey, developed and tested by authors, was distributed by e-mail to a total of 2.205 pulmonologists in Turkey. Results: Response rate was 27% (n=596). Seventy-one percent of responders were practicing NIV in clinic. NIV use was found to be associated with responder's academic title, age, duration of medical license, type of physician's hospital and its region, patient load, NIV experience during residency, and duration of NIV and intensive care unit (ICU) experience (p<0.001). Based on sub-group analysis of responders using NIV, median number of NIV patients followed-up per week was 4 [interquartile range (IQR): 2-6]. Most of the NIV users reported employment of wards (90%) and/or ICUs (86%) to follow-up patients, while 8.4% of the responders were applying NIV only in ICU's. Chronic obstructive lung disease (COPD) (99.5%), obesity hypoventilation syndrome (93.7%) and restrictive lung disease (89.4%) were the most common indications. Majority of NIV users (87%) were applying NIV to > 60% of patients with COPD, and success rate in COPD was reported as over 60% by 93% of users. Oronasal mask (median and IQR 90, 80-100%, respectively) and home care NIV ventilators (median and IQR 50, 10-85%, respectively) were the most commonly utilized equipment. Conclusion: NIV use in ARF varies based on hospital type, region and, especially, experience of the physician. Although consistent with guidelines and general practice, NIV use can still be improved and increased.Publication Metadata only Perioperative management of massive pulmonary hemorrhage after pulmonary endarterectomy(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2018) YILDIZELİ, BEDRETTİN; Yildizeli, Sehnaz Olgun; Erkilinc, Atakan; Yanartas, Mehmed; Tas, Serpil; Sunar, Hasan; Gurcu, Emre; Yildizeli, BedrettinBackground: This study aims to evaluate our approaches and outcomes in patients who developed hemoptysis following pulmonary endarterectomy. Methods: Pulmonary endarterectomy was performed in 460 patients at Kartal Kosuyolu Training and Research Hospital between March 2011 and September 2017. Clinical characteristics, perioperative management and postoperative outcomes of 10 patients (2.1%) (4 males, 6 females; mean age 48.3 +/- 16.5 years; range 21 to 76 years) with massive pulmonary hemorrhage following pulmonary endarterectomy were evaluated. Results: Mean period of diagnosis for chronic thromboembolic pulmonary hypertension was 17 +/- 13.6 months. All patients were New York Heart Association functional class II (n=2), III (n=5) or IV (n=3). For the treatment of massive pulmonary hemorrhage, intraoperative extracorporeal membrane oxygenation was used in six patients (60%), while conservative treatments were used in four patients (40%). In-hospital mortality rate was 50% (n=5); the causes for mortality were septic shock in two patients, multiple organ failure in two patients and intracranial hemorrhage in one patient. Survival was achieved in two patients on extracorporeal membrane oxygenation and three patients receiving conservative treatment. Functional and hemodynamic improvement was observed in all surviving patients. Conclusion: Despite the relatively low incidence of massive pulmonary hemorrhage after pulmonary endarterectomy, it is a potentially fatal complication. Our approach focuses on early diagnosis with a multidisciplinary team and management with bronchoscopy, bronchial blockers and use of extracorporeal membrane oxygenation. The choice of treatment depends on the site and origin of the hemorrhage, the availability of equipment and expertise, and the potential short- and long-term advantages and disadvantages.Publication Metadata only Aktif kanaması olan vena cava superior sendromuna yol açan venöz tromboz olgusunda antikoagülan tedavi yaklaşımı(2015-04-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; BEKIR KULAH M., KOCAKAYA D., OLGUN YILDIZELİ Ş., CEYHAN B.