Person: BİLĞİÇ ALKAYA, DİLEK
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BİLĞİÇ ALKAYA
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DİLEK
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Publication Metadata only Fabrication and characterization of naringenin-loaded poly(lactic acid) (pla) nanofibrous scaffolds(2022-11-26) BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Erdağ Z., Yeşil E., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Preparation and characterization of electrospun polylactic acid/sodium alginate/orange oyster shell composite nanofiber for biomedical application(SPRINGER, 2020) BİLĞİÇ ALKAYA, DİLEK; Cesur, Sumeyye; Oktar, Faik Nuzhet; Ekren, Nazmi; Kilic, Osman; Alkaya, Dilek Bilgic; Seyhan, Serap Ayaz; Ege, Zeynep Ruya; Lin, Chi-Chang; Erdem, Serap; Erdemir, Gokce; Gunduz, OguzhanBone tissue engineering has begun to draw attention in recent years. The interactive combination of biomaterials and cells is part of bone tissue engineering. Sodium alginate (SA) is a biologically compatible, degradable, non-toxic natural polymer accepted by the human body and is widely used in the field of tissue engineering. Polylactic acid (PLA) is another type of biodegradable thermoplastic polyester derived from renewable sources which are used in bone tissue engineering and biomedical owing to its biocompatibility and biodegradability. Hydroxyapatite (HA) and tricalcium phosphate (TCP) derived from natural sources such as marine species and bovine bone are biocompatible and non-toxic biomaterials which are used to reconstruct many parts of the skeleton. In this study, PLA, SA with different compositions, and nanofibers obtained by adding orange spiny oyster shell powders (Spondylus barbatus) to them by using electrospining technique. Cell culture study, scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and physical analysis such as density, electrical conductivity, surface tension, viscosity measurement, and tensile strength measurement tests were carried out after the production process. Produced nanofibers showed smooth and beadless surface. The average diameters and distributions decreased with the addition of optimum PLA and TCP amount. The tensile strength of nanofibers was enhanced with the additional SA and TCP. The produced nanofibers are compatible with human bone tissue, which are not cytotoxic, and in addition, a high cell efficiency of SaOS-2 cells on the nanofibers was observed with SEM images.Publication Metadata only Inula helenium extract-loaded nanofibrous patches for the treatment of cancer(2023-06-30) CESUR, SÜMEYYE; BİLĞİÇ ALKAYA, DİLEK; GÜNDÜZ, OĞUZHAN; Sulutas R. B., Cesur S., Ayaz-Seyhan S., Bilğiç Alkaya D., Gündüz O.Publication Metadata only Synthesis of medicinal plant based bioactive electrospun nanofibrous mats and their effect on the antioxidant activity(2022-06-24) AYAZ SEYHAN, SERAP; GÜNDÜZ, OĞUZHAN; BİLĞİÇ ALKAYA, DİLEK; Demirel A. B., AYAZ SEYHAN S., BİLĞİÇ ALKAYA D., CESUR S., GÜNDÜZ O.Publication Metadata only Inula helenium loaded nanofibers mat for medical application(2023-06-28) CESUR, SÜMEYYE; AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; GÜNDÜZ, OĞUZHAN; SULUTAŞ R. B., CESUR S., AYAZ SEYHAN S., BİLĞİÇ ALKAYA D., GÜNDÜZ O.Cancer is one of the leading causes of death worldwide. Biomaterials produced with nanotechnological methods for cancer treatment are more effective and complementary than existing treatment strategies. Nanofiber scaffolds are biomaterials that can be used in cancer treatment and can be produced in composites with biocompatible polymers and anti-cancer drugs, plant extracts. The electrospin device used for the production of these materials creates nanofiber networks by providing the electric field between the needle tip and the metal collector, which transmits the polymer solution. PLA is a biodegradable synthetic material preferred in tissue engineering studies and is a biocompatible, high mechanical strength, low cost polymer suitable for use in drug delivery systems. PVP is a polymer with good adhesion, high physiological compatibility, low toxicity and easily soluble in most organic solvents, especially used in the pharmaceutical industry. The extract of the plant Inula helenium, whose main component consists of sesquiterpene lactones, is also used in treatments for cancer. This component, which has various biological activities, has a significant anti-cancer effect. In this study, the polymer ratio used in the production of nanofiber scaffold obtained by adding Inula helenium extract is 75% PLA-chloroform / 25% PVP-ethanol and 1% Tween 80. The surface morphology of the produced fiber material was determined according to the results in the SEM images. The diameters of the fibers were measured and given in the histogram graph. FT-IR for chemical structure between bonds and DSC tests for thermal behavior analysis were applied. Tensile test was performed for mechanical analysis. Swelling-degradation test was performed and drug release kinetic data were calculated by UV spectrophotometer. In addition, its effectiveness on cancerous cells was examined by MTT analysis. In conclusion, Inula helenium extract-loaded nanofibers can reduce the risk of local recurrence of cancer after surgery and can be directly implanted into solid tumor cells for treatmentPublication Metadata only Synthesis of medicinal plant based bioactive electrospun nanofibrous mats and their effect on the antioxidant activity(2022-06-24) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Demirel A. B., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Production and Characterization of a Dual Drug Delivery System of Memantine and Naringenin by Electrospinning Method(2023-06-30) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Birinci A., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Open Access Preparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery(2022-09-01) OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; AYAZ SEYHAN S., Alkaya D., Cesur S., OKTAR F. N., GÜNDÜZ O.The marine species are specially used for the fabrication of bioceramic nano-powders with natural methods for their use in controlled drug delivery. However, there are only very limited studies regarding the production and synthesis of hydroxyapatite (HA)-based drug delivery systems from marine structures. In this study, poly (vinyl alcohol) (PVA) containing Rifampicin (RIF)-loaded Orange Spiny Oyster Seashell (Spondylus barbatus) hydroxyapatite (HA) composite is synthesized by an in situ ultrasound-assisted method. All samples were analyzed by X-ray diffraction (XRD), Fourier transforms infrared (FTIR) spectroscopy, and Scanning electron microscope (SEM), respectively. The in vitro drug release tests of the obtained samples were performed in a phosphate-buffered medium (PBS) at 37 degrees C. Drug release was evaluated according to five varying kinetic models. In vitro RIF release from HA/PVA composite in phosphate buffer (pH 7.4) showed prolonged sustained drug release. From the drug release kinetic models, Higuchi and Korsmeyer-Peppas were found to be the best model for the three ratios based on the correlation coefficient. The diffusion component is less than 0.5, which indicates quasi-fickian diffusion. From the kinetic study results, the RIF-loaded marine phase composite has potential use in drug delivery applications as it shows positive sustained drug release behavior.Publication Metadata only Fabrication and characterization of naringenin-loaded poly(Lactic Acid) (PLA) nanofibrous scaffolds(2022-11-30) AYAZ SEYHAN, SERAP; GÜNDÜZ, OĞUZHAN; BİLĞİÇ ALKAYA, DİLEK; ERDAĞ Z., YEŞİL E., BİLĞİÇ ALKAYA D., AYAZ SEYHAN S., CESUR S., GÜNDÜZ O.Publication Metadata only Characterization and application of silver nanoparticles decorated electrospun nanofiber loaded with naringenin(2022-06-24) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Birinci A., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Nanoparticles are an innovative class of functional materials. Silver nanoparticles (AgNPs) are extensively applied in different fields of science, such as biomedical science, including antibacterial, antiviral, anti-inflammatory, and anticancer therapies. Also, AgNPs are being used to produce various biomedical products to prevent infection. The application of AgNPs has been widened due to recent advances in nanotechnology. AgNPs have several important implications including medical diagnostics, therapeutics, antioxidant, antibacterial, and cytotoxic properties. Many natural biomolecules in plants (inactivated plant tissue, plant extracts and living plant) such as proteins/enzymes, amino acids, polysaccharides, alkaloids, alcoholic compounds, and vitamins could be involved in bioreduction, formation and stabilization of AgNPs. Naringenin (4′,5,7-trihydroxyflavanone) (NRG) is a bioflavonoid widely present in fruits; it has been reported to have antioxidant, free radical scavenging, anticancer, anti-inflammatory, immunomodulating and memory enhancing properties. Its antioxidant effects may make NRG a potential drug for treating Alzheimer disease (AD). Recently, NRG was found to exhibit neuroprotective effect in models of Parkinson's disease (PD) and AD, such as the ICV-STZ-induced mode of AD and the 6-OHDA model of PD. Nanocomposite materials consisting of metallic nanoparticles incorporated in or with polymers have attracted much attention because of their distinct optical, electrical and catalytic properties, which have potential applications in the fields of catalysis, bioengineering, photonics, and electronics. Silver nanoparticles have been immobilized into polymer-based nanofibers to introduce hybrid multifunctional substrates for a variety of applications. In this study, nanostructured metal-polymer hybrid (AgNPsNRG-PLA) nanofibers were obtained by electrospinning technique.The nanostructured metal-polymer hybrid (AgNPs-NRG-PLA) nanofibers were characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), thermal analysis (DSC) and tensile strength and physical analyzes such as density, surface tension, particle viscosity were performed.