Person: BİLĞİÇ ALKAYA, DİLEK
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BİLĞİÇ ALKAYA
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DİLEK
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Publication Metadata only Fabrication and characterization of naringenin-loaded poly(lactic acid) (pla) nanofibrous scaffolds(2022-11-26) BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Erdağ Z., Yeşil E., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Inula helenium extract-loaded nanofibrous patches for the treatment of cancer(2023-06-30) CESUR, SÜMEYYE; BİLĞİÇ ALKAYA, DİLEK; GÜNDÜZ, OĞUZHAN; Sulutas R. B., Cesur S., Ayaz-Seyhan S., Bilğiç Alkaya D., Gündüz O.Publication Metadata only Synthesis of medicinal plant based bioactive electrospun nanofibrous mats and their effect on the antioxidant activity(2022-06-24) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Demirel A. B., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Production and Characterization of a Dual Drug Delivery System of Memantine and Naringenin by Electrospinning Method(2023-06-30) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Birinci A., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Open Access Preparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery(2022-09-01) OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; AYAZ SEYHAN S., Alkaya D., Cesur S., OKTAR F. N., GÜNDÜZ O.The marine species are specially used for the fabrication of bioceramic nano-powders with natural methods for their use in controlled drug delivery. However, there are only very limited studies regarding the production and synthesis of hydroxyapatite (HA)-based drug delivery systems from marine structures. In this study, poly (vinyl alcohol) (PVA) containing Rifampicin (RIF)-loaded Orange Spiny Oyster Seashell (Spondylus barbatus) hydroxyapatite (HA) composite is synthesized by an in situ ultrasound-assisted method. All samples were analyzed by X-ray diffraction (XRD), Fourier transforms infrared (FTIR) spectroscopy, and Scanning electron microscope (SEM), respectively. The in vitro drug release tests of the obtained samples were performed in a phosphate-buffered medium (PBS) at 37 degrees C. Drug release was evaluated according to five varying kinetic models. In vitro RIF release from HA/PVA composite in phosphate buffer (pH 7.4) showed prolonged sustained drug release. From the drug release kinetic models, Higuchi and Korsmeyer-Peppas were found to be the best model for the three ratios based on the correlation coefficient. The diffusion component is less than 0.5, which indicates quasi-fickian diffusion. From the kinetic study results, the RIF-loaded marine phase composite has potential use in drug delivery applications as it shows positive sustained drug release behavior.Publication Metadata only Characterization and application of silver nanoparticles decorated electrospun nanofiber loaded with naringenin(2022-06-24) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Birinci A., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Nanoparticles are an innovative class of functional materials. Silver nanoparticles (AgNPs) are extensively applied in different fields of science, such as biomedical science, including antibacterial, antiviral, anti-inflammatory, and anticancer therapies. Also, AgNPs are being used to produce various biomedical products to prevent infection. The application of AgNPs has been widened due to recent advances in nanotechnology. AgNPs have several important implications including medical diagnostics, therapeutics, antioxidant, antibacterial, and cytotoxic properties. Many natural biomolecules in plants (inactivated plant tissue, plant extracts and living plant) such as proteins/enzymes, amino acids, polysaccharides, alkaloids, alcoholic compounds, and vitamins could be involved in bioreduction, formation and stabilization of AgNPs. Naringenin (4′,5,7-trihydroxyflavanone) (NRG) is a bioflavonoid widely present in fruits; it has been reported to have antioxidant, free radical scavenging, anticancer, anti-inflammatory, immunomodulating and memory enhancing properties. Its antioxidant effects may make NRG a potential drug for treating Alzheimer disease (AD). Recently, NRG was found to exhibit neuroprotective effect in models of Parkinson's disease (PD) and AD, such as the ICV-STZ-induced mode of AD and the 6-OHDA model of PD. Nanocomposite materials consisting of metallic nanoparticles incorporated in or with polymers have attracted much attention because of their distinct optical, electrical and catalytic properties, which have potential applications in the fields of catalysis, bioengineering, photonics, and electronics. Silver nanoparticles have been immobilized into polymer-based nanofibers to introduce hybrid multifunctional substrates for a variety of applications. In this study, nanostructured metal-polymer hybrid (AgNPsNRG-PLA) nanofibers were obtained by electrospinning technique.The nanostructured metal-polymer hybrid (AgNPs-NRG-PLA) nanofibers were characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), thermal analysis (DSC) and tensile strength and physical analyzes such as density, surface tension, particle viscosity were performed.Publication Metadata only Production of nanofiber for combination with anticancer tragopon porrifolius L. Naringenin(2023-06-30) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Yeşil E., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Design and characterization of medicinal plant based nanofibers and their effect on the antioxidant activity(2022-06-24) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Ekici T., Doğrul E., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.Publication Metadata only Donezepil for the treatment of alzheimer's disease-loaded with curcumin production of sandwich-like 3D PCL/PVA tissue scaffolds(2023-06-30) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Ekici T., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.Publication Metadata only Fabrication and Characterization of Carbamazepine Loaded Poly(lactic acid) (PLA) Nanofibrous Scaffolds(2021-06-26) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.