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BİLĞİÇ ALKAYA, DİLEK

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BİLĞİÇ ALKAYA

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DİLEK

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2019 - 201912020 - 20231
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Has files: true × Subject: antioxidant activity ×

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    PublicationOpen Access
    Influence of extraction method on antioxidant properties of Rheum ribes root extract
    (OVIDIUS UNIV PRESS, 2019-01-01) BİLĞİÇ ALKAYA, DİLEK; Bilgic Alkaya, Dilek; Ayaz Seyhan, Serap; Ozturk, Busra Nagihan
    Rheum species are important medicinal herbs, often used in pharmacological research, due to the presence of anthracene derivatives in the subterranean parts of the plant. In this study, we intended to assess its antioxidant capacity, in correlation with the method of extraction. For this purpose, Rheum ribes extraction was realized with four solvents of different polarities (50% methanol, 70% ethanol, 80% acetonitrile, and petroleum ether). We used different extraction techniques, such as orbital shaker, ultrasonic stirrer, microwave, and Soxhlet extraction, and the total phenolic content of the Rheum ribes extracts was determined by modified Folin-Ciocalteu method. The reducing power and radical scavenging activity of the extracts were also evaluated. The results shown that the antioxidant activity of the extracts depends on the extraction methods especially through the used solvent and decreases in the order: ethanol > methanol > acetonitrile > petroleum ether.
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    PublicationOpen Access
    Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers
    (2023-01-01) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN S., Demirel A. B., Cesur S., BİLĞİÇ ALKAYA D.
    © 2023 Marmara University Press.The use of natural compounds such as biocompatible and non-toxic plant extracts, without undesired side effects, in tissue engineering applications, is highly preferred compared to chemical drugs. In recent years, many studies have been carried out to produce nanofibrous materials produced by electrospinning of bioactive plant extracts. Electrospun nanofibers have very large surface area, controllable pore size, and tunable drug release profiles. Several biocompatible polymers with excellent biocompatibility and biodegradability including poly ethylene glycol (PEG) and poly-lactic acid (PLA) have been widely used for the synthesis of nanofibers using the electrospun technique. The ethanol-water extract of the root parts of the Rheum ribes L. plant has antioxidant, antimicrobial, and antiurease effects. In this study, the characterization and performance of electrospun Rheum ribes L.-loaded (20 mg, 40 mg, and 60 mg in 20mL) poly (lactic acid) (PLA) (8%, w/v) /Polyethylene glycol (PEG) (1%, w/v) /Tween 80 (3%, w/v) nanofibrous mats for skin tissue engineering were investigated. Morphological (SEM), molecular interaction (FT-IR), thermal analysis (DSC), antioxidant activity and physical analysis were carried out after the production process. According to the results obtained, Rheum ribes L.-loaded PLA/PEG nanofibers have smooth fiber morphology in fine structure without beads, proper tensile strength and antioxidant activity. Consequently, Rheum ribes L.-loaded nanofibrous mats are suitable for skin tissue engineering applications.