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CEBECİ, AYBİKE

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CEBECİ

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AYBİKE

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  • PublicationOpen Access
    Biochemical relationship between glucose-6-phosphate dehydrogenase deficiency and covıd-19 and effects of glutathione supplements
    (2022-01-01) OĞUZ, ESMA; CEBECİ, AYBİKE; OĞUZ E., CEBECİ A.
    Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway involved in the production of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH). One of the most common inherited enzyme abnormalities is G6PD deficiency. G6PD enzyme deficiency facilitates human coronavirus infection due to glutathione (GSH) depletion. Depletion of glutathione due to blockage of the pentose phosphate pathway can hardly preserve the oxidative and anti-oxidative balance. GSH protects the body from the harmful effects of oxidative damage from excess reactive oxygen radicals. Levels of GSH, the key antioxidant protector in all tissues, could be critical in quenching the exacerbated inflammation that triggers organ failure in the new coronavirus disease (COVID-19). Since several amino acids intersect with the GSH pathway, changing the concentrations of these amino acids directly or indirectly can alter cellular GSH homeostasis. Supplementation of amino acids and as well as the implementation of diet strategies offer safe and non-invasive strategies for improving GSH status and protect the body from oxidative stress in various diseases and conditions. The purpose of this review is to examine the biochemical relationship between G6PD deficiency and COVID-19 and the effect of GSH on this disease.
  • Publication
    The relationship between nutrition and Meniere's disease
    (ELSEVIER SCI LTD, 2021) CEBECİ, AYBİKE; Oguz, Esma; Cebeci, Aybike; Gecici, Cennet Reyyan
    Meniere's disease is an inner ear disease with attacks characterized by ear fullness, tinnitus, fluctuant sensorineural hearing loss and vertigo. Although pathophysiology of the disease is not fully known, endolymphatic hydrops are believed to play a role. Although there is no certain treatment procedure for Meniere's disease, some treatments are applied to prevent attacks, to treat the symptoms that occur during the attacks, and to prevent the permanent effects of the symptoms on the hearing and balance system. Lifestyle changes, dietary modifications, diuretics, vasodilator corticosteroids, intratympanic steroids, surgical methods are some of these treatment methods. Dietary modification includes a low sodium diet, a reduction in daily alcohol and caffeine intake, a gluten-free diet, and a new dietary approach to specially processed grains, all of which are first-line treatments. The goal of this review article is to examine the relationship between MD and dietary intervention, which is frequently used in the prevention and treatment of MD attacks. (C) 2021 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.