Person: ŞAHİN, AKIN
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ŞAHİN
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AKIN
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Publication Open Access The promising role of Gelsolin expression to predict survival in patients with squamous cell carcinoma of the larynx(2021-06) BATMAN, ABDULLAH ÇAĞLAR; Şahin, Akın; Enver, Necati; Erçetin, Selim Yiğit; Cinel, Zeliha Leyla; Batman, Abdullah ÇağlarPublication Open Access Relationship of PPARG overexpression with prognostic parameters in papillary thyroid carcinoma(2022-02-01) ASYA, ORHAN; YUMUŞAKHUYLU, ALİ CEMAL; BAĞCI ÇULÇİ, PELİN; ŞAHİN, AKIN; OYSU, ÇAĞATAY; KAYA, HANDAN; ASYA O., YUMUŞAKHUYLU A. C., BAĞCI ÇULÇİ P., KAYA H., Gonen A., Gundogdu Y., Muradov T., ŞAHİN A., OYSU Ç.Objectives. PAX8/PPARG chromosomal rearrangement is frequently seen in thyroid cancer, and PPARG overexpression has been shown in the follicular variant of papillary thyroid carcinoma, but not in papillary thyroid carcinoma other than the follicular variant. The main aim of this study was to investigate the frequency of PPARG overexpression among papillary thyroid carcinoma and if there were any variants of papillary thyroid carcinoma with PPARG overexpression other than the follicular variant. Methods. Immunohistochemical analysis of PPARG overexpression was performed using a PPARG monoclonal antibody in a series of 111 paraffin-embedded blocks of thyroid tumours. Of the patients in our study, 100 were diagnosed with papillary thyroid carcinoma, 9 with follicular adenoma and 2 with follicular carcinoma. Results. PPARG staining was detected in 19 of the 111 cases. Sixteen patients with PPARG overexpression had papillary thyroid carcinoma and 3 had follicular adenoma. Conclusion. PPARG overexpression was detected mainly in follicular-variant papillary thyroid carcinoma. Vascular invasion, lymphatic invasion, thyroid capsule invasion and lymph node positivity were lower in patients with PPARG overexpression.Publication Metadata only The utilization of Chronic Otitis Media Questionnaire-12 in chronic otitis media with or without cholesteatoma(SPRINGER, 2020) BİNNETOĞLU, ADEM; Demir, Berat; Sahin, Akin; Binnetoglu, Adem; Batman, CaglarObjective This study aimed to compare patients who had chronic otitis media with and without cholesteatoma in terms of the quality of life related to health. Methods The Turkish version of the Chronic Otitis Media Questionnaire-12 (COMQ-12) was completed by totally 100 healthy subjects and 100 patients who had chronic otitis media (COM). The COM group was divided into cholesteatoma and without cholesteatoma [dry tympanic membrane perforation (TMP) and draining ear] groups. Results COMQ-12 score = 3.6 for healthy people. The average scores of dry TMP, draining ear, and cholesteatoma groups were 32.90, 27.34, and 45.95, respectively. A significant difference was between the cholesteatoma and without cholesteatoma groups in total scores (p = 0.001). No difference was found between the groups in age (p = 0.518) and gender (p = 0.975). Conclusion The COMQ-12 could be a useful tool to differentiate chronic otitis media with or without cholesteatoma.Publication Metadata only Factors That May Affect Rating and Liking Scores of Septorhinoplasty Videos on YouTube(SPRINGER, 2020) ŞAHİN, AKIN; Demir, Berat; Sahin, Akin; Mammadova, Ulker; Mamadli, JavahirBackground Despite the increasing use of videos on social media platforms such as YouTube that inform patients about conditions and procedures, it is an enigma how patients benefit from these videos. Although professional healthcare providers play an important role in this regard, there are no data on video characteristics that make a video useful, or likable by the audience. We aimed to investigate that factors make a septorhinoplasty video posted on YouTube successful. Materials and Methods Video demographics, including type, source, length, and viewers' comments, were evaluated. Three researchers independently assessed videos on septorhinoplasty for attractiveness. Nine criteria, including preoperative nasal congestion, snoring, nasal deformity (visuality), surgical treatment, postoperative nasal congestion, bruising\swelling, pain, patient satisfaction, and medical treatment, were examined. Results The number of likes for the videos with preoperative nasal deformity data (visuality) was found to be significantly higher than that for the videos without preoperative nasal deformity (visuality) data. For the videos with surgical treatment data, the number of likes, the number of dislikes, the number of comments, and the total number of views were found to be significantly higher than those for the videos without surgical treatment data (pvalues 0.007, 0.016, 0.006, and 0.003 respectively). Videos with medical treatment data had a significantly higher number of comments than those without medical treatment data. Conclusion The attractiveness of a video on septorhinoplasty increases when it contain both medical and surgical treatment data.Publication Metadata only Outcomes of cochlear implantation in children with inner ear malformations(SPRINGER, 2019) BATMAN, ABDULLAH ÇAĞLAR; Demir, Berat; Cesur, Sidika; Sahin, Akin; Binnetoglu, Adem; Ciprut, Ayca; Batman, CaglarPurpose To evaluate the surgical experience and auditory functions and progress of speech development of cochlear implantation in malformed ears. Materials and methods Between November 1995 and July 2017, thirty-seven patients (26 females and 11 males; mean age: 138.275 +/- 96.24 months) with diverse anomalies of the inner ear were retrospectively examined for surgical and audiological results. Speech Intelligibility Rating (SIR), Categories of Auditory Perception (CAP), Pure Tone Average (PTA), Speech Intelligibility Rating (SRT), and Word Discrimination Score (WDS) were the audiological tests used to evaluate the efficacy of CI in the malformed inner ears. Results CSF gusher was experienced by six patients (three with LVA (large vestibular aqueduct), one with IP (incomplete partition) I, and two with both IP II Mondini malformations and LVA). Two patients had transient facial paresis after surgery. All patients fully recovered within 6 months. The postoperative PTA, SRT, and WDS test results showed significant differences between progressive and congenital sensorineural hearing loss (p values < 0.05 for all). On the other hand, the postoperative CAP and SIR test results revealed no significant differences between the two groups. According to etiology, the PTA and SRT values were significantly lower in common cavity patients than the LVA patients (p values < 0.01); no significant differences were found among the other etiological groups. Conclusions Cochlear implantation is safe in children with inner ear malformations. However, the success rate is low compared to patients with normal anatomy in terms of audiological results; the most successful group of patients with inner ear malformation is large vestibular aqueduct.