Person: ÇELİKEL, ÇİĞDEM
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ÇELİKEL
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ÇİĞDEM
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Publication Open Access Stage IV Hodgkin's disease presenting with spinal epidural involvement and cauda equina compression as the initial manifestation: Case report(1997-10-01) ÇELİKEL, ÇİĞDEM; Toprak A., Kodalli N., Alpdogan T., Giral A., Celikel Ç., Gurmen N., Bayik M.Hodgkin\"s disease very rarely presents clinically, initially with a paraspinal mass, but this should be considered in the differential diagnosis. A patient presenting with back pain was diagnosed to have Stage IV Hodgkin\"s disease. MRI revealed an extradural and intraspinal soft tissue mass with bone infiltration. The importance of MRI in the early evaluation of a paraspinal mass and in determining the extent of the disease is emphasized.Publication Metadata only Does eradication of H-pylori reduce low dose aspirin induced gastroduodenal injury(1997-04-01) ÇELİKEL, ÇİĞDEM; Giral A., Ozdogan O., Celikel Ç., Ulusoy N., Tozun N., Kalayci C.Publication Metadata only Flow cytometric DNA studies and AgNOR counts in patients with transitional cell carcinoma of the bladder(1995-01-01) ÇELİKEL, ÇİĞDEM; ÇELİKEL Ç., Dillioglugil O., Turkeri L., Basaran M., Yalciner A., Kullu S., Akdas A.Flow cytometry appears to be a promising diagnostic method which may influence the therapeutic approach to transitional cell carcinoma (TCC) of the bladder. The number of silver-stained nuclear organizer regions (AgNORs) seems to correlate with the growth fractions of the cells. In this study, we report the results of combined flow cytometric analysis and AgNOR in 37 patients with TCC of the bladder. A positive correlation was observed in the histological grade, stage and growth pattern in relation to the ploidy of tumors. There were statistically significant differences among the mean AgNOR counts of the different groups as defined by DNA content, histological grade, growth pattern and disease outcome. In different stage groups, the AgNOR counts were related both to recurrence and progression. It was concluded that AgNOR counts performed on routine formalin-fixed paraffin sections furnish significant kinetic information. According to our preliminary results AgNOR counts and the DNA content of the tumors should also be measured to decide on more aggressive treatment in some cases.Publication Metadata only Endothelin-1 in hepatorenal syndrome: Is endothelin-1 receptor antagonist (bosentan) effective(1997-04-01) ÇELİKEL, ÇİĞDEM; Ozdogan O., Goren Z., Tozun N., Moini H., Bilsel S., Celikel Ç., Kalayci C., Berkman K.Publication Metadata only Hepatic iron and fibrosis score as predictors of response to interferon in chronic hepatitis C(1996-04-01) ÇELİKEL, ÇİĞDEM; Celikel Ç., Ozdogan O., EREN F., Avsar E., Kalayci C., Tozun N., Kullu S.Publication Metadata only DNA ploidy and proliferating cell nuclear antigen in colonic adenomas: Can they predict recurrence(1996-04-01) ÇELİKEL, ÇİĞDEM; Celikel Ç., Demiralp E., EKİCİOĞLU G., Avsar E., Kullu S., Akoglu T.To investigate the colonic adenoma-adenocarcinoma progression sequence, DNA ploidy analysis was performed on hyperplastic polyps to adenocarcinomas. DNA ploidy data were then compared with immunocytochemical staining for proliferating cell nuclear antigen (PCNA). In hyperplastic polyps to villous adenomas, all cases were diploid except one aneuploid villous adenoma. In three adenomas, diploid in situ adenocarcinomas were present. As diploid percentages decreased from hyperplastic polyps to villous adenomas, aneuploid percentages increased. In adenocarcinomas, the Dukes classification corresponded well to DNA ploidy status: all four stage A carcinomas were diploid, whereas three cases each of stage C1 and C2 carcinomas were aneuploid or multiploid. A surprising finding was that S-phase percentage in adenocarcinomas was not parallel with PCNA-positive tumor cell numbers. It is concluded that multistep adenoma-adenocarcinoma progression was partially reflected in DNA ploidy pattern from hyperplastic polyps to villous adenomas. In adenocarcinomas, the Dukes classification paralleled well the DNA ploidy status from stage A diploid to stage D aneuploid, but was not accompanied by increasing PCNA-positive cell numbersPublication Open Access Early recurrence of malignant fibrous histiocytoma of the heart(1996-03-01) ÇELİKEL, ÇİĞDEM; Basaran Y., Degertekin M., Balkanay M., Akinci E., Celikel Ç., Dizdar H., Turan F., Yakut C.Malignant fibrous histiocytoma is a pleomorphic soft tissue sarcoma, which constitutes only 2% of all cardiac malignancies and is typically located in the left atrium. We report a young male patient with malignant fibrous histiocytoma located on, the right side of the heart. Early recurrence was observed after extensive surgical resection to relieve symptoms of outflow tract obstruction. Noninvasive evaluation, and management with regard to the literature are discussed.Publication Open Access Effect of inhaled ingredients of a commercial cyclosporin A ampoule on airway inflammation(1998-01-01) ÇELİKEL, ÇİĞDEM; Ceyhan B., Sungur M., Celikel Ç., Celikel T.