Person: ÇELİKEL, ÇİĞDEM
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ÇELİKEL
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ÇİĞDEM
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Publication Metadata only Comparison of different chronic hepatitis scores with respect to interobserver variability: A study of Turkish National Working Group of Hepato-pancreato-biliary Pathology(2007-08-01) ÇELİKEL, ÇİĞDEM; YILMAZ BARBET F., Akarca U. S., Akyol G., Celikel Ç., Erden E., Nart D., Sokmensuer C., Ozbay G.Publication Metadata only Effects of pentoxifylline on tnf-alpha production by peripheral blood mononuclear cells in patients with nonalcoholic steatohepatitis(2006-04-01) ÇELİKEL, ÇİĞDEM; Duman D. G., Ozdemir F., Birben E., Keskin O., Demiralp E., Celikel Ç., Kalayci O., Kalayci C.Publication Metadata only Is there a role for adipocytokines on the effect of anti-TNF treatment in an experimental model of colitis(2008-04-01) ÇELİKEL, ÇİĞDEM; Yapali S., Deniz M., EREN F., Imeryuz N., Celikel Ç., Ozkan N., Tahan V., Hamzaoglu H. O., Tozun N.Publication Metadata only Epithelioid hemangioendothelioma with multiple organ involvement(WILEY, 2007) ÇELİKEL, ÇİĞDEM; Celikel, Cigdem; Yumuk, P. Fulden; Basaran, Gul; Yildizeli, Berdrettin; Kodalli, Nihat; Ahiskali, RenginEpithelioid hemangioendothelioma is a rare vascular neoplasm of uncertain malignant potential. Various reports document metastatic or concurrent epithelioid hemangioendothelioma in several sites, most commonly with combined lung and liver involvement. The concurrent involvement of multiple sites at presentation may cause diagnostic problems because epithelioid hemangioendothelioma can mimic other neoplastic processes. Although it is a chemoresistant disease, chemotherapy is usually advised for patients with metastatic or concurrent involvement. Here we document the presentation, treatment, and outcome of two cases with concurrent involvement of the lung and liver.Publication Metadata only Vascular endothelial growth factor, hypoxia-inducible factor 1 alpha and CD34 expressions in early-stage gastric tumors: Relationship with pathological factors and prognostic impact on survival(KARGER, 2007) ÇELİKEL, ÇİĞDEM; Cabuk, Devrim; Basaran, Gul; Celikel, Cigdem; Dane, Faysal; Yumuk, P. Fulden; Iyikesici, M. Salih; Ekenel, Meltem; Turhal, N. SerdarBackground: Angiogenesis is one of the key steps in solid tumor growth and metastasis. We planned to investigate the prognostic significance of vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1 alpha (HIF-1 alpha) and CD34 expressions as markers of angiogenesis in gastric cancer. Patients and Methods: We retrospectively reviewed the medical records of 51 gastric cancer patients who had total or subtotal gastrectomy at Marmara University Hospital from 1990 to 2004 and evaluated the expression of VEGF, HIF-1 alpha and CD34 by immunohistochemistry in their archival tumor tissues. We recorded the clinical and pathological characteristics of these patients and analyzed their survival outcome. Results: Thirty out of 51 patients were males. The median age was 63 years (range 34-81). The median follow-up was 17 months. Thirty-six patients had node-positive disease. The majority of patients (n = 43) had T2 and T3 disease. Vascular and lymphatic invasions were present in 57 and 77% of tumors, respectively. VEGF and HIF-1 alpha were positive in 65 and 71% of tumors. The median CD34 staining score was 19 (3-68). VEGF, HIF-1 alpha and CD34 expressions were more frequent in tumors without serosal invasion (p = 0.01, p = 0.01 and p = 0.003, respectively). CD34 expression was significantly more frequent in tumors with VEGF and HIF-1 alpha expression (p = 0.00, p = 0.00). HIF-1 alpha expression was more frequent in tumors with VEGF expression (p = 0.00). The 5year overall survival was 45%. VEGF, HIF-1 alpha, CD34 expressions and other pathological characteristics were found to have no impact on survival. Conclusion: VEGF, HIF-1 alpha and CD34 expressions were more common in tumors without serosal invasion. As a future perspective, biological agents targeting VEGF and HIF-1 alpha might be more effective at earlier stages of gastric cancer. Copyright (c) 2007 S. Karger AG, Basel.Publication Metadata only Does eradication of H-pylori reduce low dose aspirin induced gastroduodenal injury(1997-04-01) ÇELİKEL, ÇİĞDEM; Giral A., Ozdogan O., Celikel Ç., Ulusoy N., Tozun N., Kalayci C.Publication Metadata only Flow cytometric DNA studies and AgNOR counts in patients with transitional cell carcinoma of the bladder(1995-01-01) ÇELİKEL, ÇİĞDEM; ÇELİKEL Ç., Dillioglugil O., Turkeri L., Basaran M., Yalciner A., Kullu S., Akdas A.Flow cytometry appears to be a promising diagnostic method which may influence the therapeutic approach to transitional cell carcinoma (TCC) of the bladder. The number of silver-stained nuclear organizer regions (AgNORs) seems to correlate with the growth fractions of the cells. In this study, we report the results of combined flow cytometric analysis and AgNOR in 37 patients with TCC of the bladder. A positive correlation was observed in the histological grade, stage and growth pattern in relation to the ploidy of tumors. There were statistically significant differences among the mean AgNOR counts of the different groups as defined by DNA content, histological grade, growth pattern and disease outcome. In different stage groups, the AgNOR counts were related both to recurrence and progression. It was concluded that AgNOR counts performed on routine formalin-fixed paraffin sections furnish significant kinetic information. According to our preliminary results AgNOR counts and the DNA content of the tumors should also be measured to decide on more aggressive treatment in some cases.Publication Metadata only Endothelin-1 in hepatorenal syndrome: Is endothelin-1 receptor antagonist (bosentan) effective(1997-04-01) ÇELİKEL, ÇİĞDEM; Ozdogan O., Goren Z., Tozun N., Moini H., Bilsel S., Celikel Ç., Kalayci C., Berkman K.Publication Metadata only Mononuclear cell phenotypes in nonalcoholic fatty liver disease: Comparison with chronic hepatitis C(2007-08-01) ÇELİKEL, ÇİĞDEM; Celikel Ç., Bas E., Ozkan N., Duman D., Avsar E.Publication Metadata only Serum prolidase and IGF-1 as non-invasive markers of hepatic fibrosis during four different periods after bile-duct ligation in rats(SPRINGER, 2008) ÇELİKEL, ÇİĞDEM; Tarcin, Orhan; Gedik, Nursal; Karakoyun, Berna; Tahan, Veysel; Sood, Gagan; Celikel, Cigdem; Tozun, NurdanAim Our aim was to study the correlation of serum prolidase and insulin like growth factor-1 to liver collagen and assess their utility as markers of fibrosis during four different periods of hepatic injury and fibrosis after bile-duct ligation in rats. Methods Forty-eight Wistar albino rats were included in the study and divided into six groups. Seven rats served as the control group (Control), while seven rats had a sham operation (Sham group). Thirty-four rats underwent bile-duct ligation. Bile-duct ligated (BDL) animals were sacrificed at the end of the first week (Group 1; n = 8), second week (Group 2; n = 8), third week (Group 3; n = 9), or fourth week (Group 4; n = 9) after BDL. Liver collagen, liver prolidase, and serum prolidase and IGF-1, were determined. Results There was a positive correlation between liver collagen and serum prolidase (r(s): 0.843, P < 0.001) levels and a negative correlation among liver collagen and serum IGF-1 levels (r(s): -0.667, P < 0.001). The peak levels of liver collagen and serum prolidase were reached in the third week while the lowest levels of IGF-1 were found at the end of the third week. Conclusion Serum prolidase and IGF-1 either independently or in combination correlate with liver collagen content in hepatic fibrosis.