Person: ÇELİKEL, ÇİĞDEM
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ÇELİKEL
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ÇİĞDEM
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Publication Metadata only Effects of pentoxifylline on tnf-alpha production by peripheral blood mononuclear cells in patients with nonalcoholic steatohepatitis(2006-04-01) ÇELİKEL, ÇİĞDEM; Duman D. G., Ozdemir F., Birben E., Keskin O., Demiralp E., Celikel Ç., Kalayci O., Kalayci C.Publication Metadata only Is there a role for adipocytokines on the effect of anti-TNF treatment in an experimental model of colitis(2008-04-01) ÇELİKEL, ÇİĞDEM; Yapali S., Deniz M., EREN F., Imeryuz N., Celikel Ç., Ozkan N., Tahan V., Hamzaoglu H. O., Tozun N.Publication Open Access Stage IV Hodgkin's disease presenting with spinal epidural involvement and cauda equina compression as the initial manifestation: Case report(1997-10-01) ÇELİKEL, ÇİĞDEM; Toprak A., Kodalli N., Alpdogan T., Giral A., Celikel Ç., Gurmen N., Bayik M.Hodgkin\"s disease very rarely presents clinically, initially with a paraspinal mass, but this should be considered in the differential diagnosis. A patient presenting with back pain was diagnosed to have Stage IV Hodgkin\"s disease. MRI revealed an extradural and intraspinal soft tissue mass with bone infiltration. The importance of MRI in the early evaluation of a paraspinal mass and in determining the extent of the disease is emphasized.Publication Metadata only Does eradication of H-pylori reduce low dose aspirin induced gastroduodenal injury(1997-04-01) ÇELİKEL, ÇİĞDEM; Giral A., Ozdogan O., Celikel Ç., Ulusoy N., Tozun N., Kalayci C.Publication Metadata only Flow cytometric DNA studies and AgNOR counts in patients with transitional cell carcinoma of the bladder(1995-01-01) ÇELİKEL, ÇİĞDEM; ÇELİKEL Ç., Dillioglugil O., Turkeri L., Basaran M., Yalciner A., Kullu S., Akdas A.Flow cytometry appears to be a promising diagnostic method which may influence the therapeutic approach to transitional cell carcinoma (TCC) of the bladder. The number of silver-stained nuclear organizer regions (AgNORs) seems to correlate with the growth fractions of the cells. In this study, we report the results of combined flow cytometric analysis and AgNOR in 37 patients with TCC of the bladder. A positive correlation was observed in the histological grade, stage and growth pattern in relation to the ploidy of tumors. There were statistically significant differences among the mean AgNOR counts of the different groups as defined by DNA content, histological grade, growth pattern and disease outcome. In different stage groups, the AgNOR counts were related both to recurrence and progression. It was concluded that AgNOR counts performed on routine formalin-fixed paraffin sections furnish significant kinetic information. According to our preliminary results AgNOR counts and the DNA content of the tumors should also be measured to decide on more aggressive treatment in some cases.Publication Metadata only Endothelin-1 in hepatorenal syndrome: Is endothelin-1 receptor antagonist (bosentan) effective(1997-04-01) ÇELİKEL, ÇİĞDEM; Ozdogan O., Goren Z., Tozun N., Moini H., Bilsel S., Celikel Ç., Kalayci C., Berkman K.Publication Metadata only Hepatic iron and fibrosis score as predictors of response to interferon in chronic hepatitis C(1996-04-01) ÇELİKEL, ÇİĞDEM; Celikel Ç., Ozdogan O., EREN F., Avsar E., Kalayci C., Tozun N., Kullu S.Publication Open Access Malign melanom, endobronşial metastaz(2009-04-09) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; ÇELİKEL, ÇİĞDEM; KARAKURT, SAİT; Kocakaya D., Abul Y., Olgun Yıldızeli Ş., Eryüksel S. E., Tosuner Z., Yazıcı Z., Çelikel Ç., Karakurt S.Amaç: Malign melanoma melanositlerin malign transfomayonu sonucu gelişir.Pulmoner metastazını pulmoner arterlere ulaşan tümör embolileri yoluyla yapar.Endobronşial yayılımlı malign melonom vakaları sınırlı sayıdadır. Gereç ve Yöntem: Nadir görülen endobronşial yayılım yapmış bronkoskopi ile tanı koyduğumuz vakamızı sunduk. Bulgular: 42 yaşında bayan hasta nefes darlığı şikaye ile başvurdu. 2006 da tanı konan sır a konjenital dev nevüs tanısı mevcu u.5 paket/yıl sigara hikayesi mevcu u. Fizik muayenede bel bölgesinde 25x15 cm boyularında yaklaşık tüm lumbar bölgeyi kaplayan gluteal bölgeye de yayılan dev nevüsü mevcu u. Vücu a özellikle sır a ve saçlı deride birden fazla çok sayıda nevüsler izlendi. Nevüslerde renk değişikliği tariflemiyordu. Sır aki dev nevüste kalınlaşma belir yordu. Solunum sistemi muayenesi doğaldı.Aksiller ele gelen 1x2 cm lik lenfadenopa si mevcu u. PA akciğer grafisinde sol hilar bölgede düzensizlik ve dansite ar şı mevcu u. Toraks BT’de sol üst lobda 40x30 mm kitlesel lezyon mevcu u. Bronkoskopide sol akciğer üst lob girişinde nevüs tarzında siyahımsı mukozadan kabarık endobronşial lezyon izlendi. Alınan bronkoskopik biyopsi, rça ve bronkoalveolar lavaj materyalleri malign melonom ile uyumlu geldi. Sonuç: Malign melanoma bağlı endobronşial metastaz nadirdir. Literatürde 1966-2002 yılları arası yapılmış geniş taramada 204 akciğer dışı kaynaklı endobronşial metastaz vakası saptanmış olup bunları sırasıyla meme(%35), böbrek(%17), kolon ve rektum(%15) oluşturmaktadır.. Deri kanseri vakaları sadece 9 vaka olup , 7’si malign melanom kökenli saptanmış r. Tanıda primer akciğer kanserinden ayırtetmek için bronkoskopi şar r. Malign melannomaya bağlı endobronşial metastazı olgumuzu literatürde nadir görülmEsi nedeniyle sunduk.Publication Metadata only DNA ploidy and proliferating cell nuclear antigen in colonic adenomas: Can they predict recurrence(1996-04-01) ÇELİKEL, ÇİĞDEM; Celikel Ç., Demiralp E., EKİCİOĞLU G., Avsar E., Kullu S., Akoglu T.To investigate the colonic adenoma-adenocarcinoma progression sequence, DNA ploidy analysis was performed on hyperplastic polyps to adenocarcinomas. DNA ploidy data were then compared with immunocytochemical staining for proliferating cell nuclear antigen (PCNA). In hyperplastic polyps to villous adenomas, all cases were diploid except one aneuploid villous adenoma. In three adenomas, diploid in situ adenocarcinomas were present. As diploid percentages decreased from hyperplastic polyps to villous adenomas, aneuploid percentages increased. In adenocarcinomas, the Dukes classification corresponded well to DNA ploidy status: all four stage A carcinomas were diploid, whereas three cases each of stage C1 and C2 carcinomas were aneuploid or multiploid. A surprising finding was that S-phase percentage in adenocarcinomas was not parallel with PCNA-positive tumor cell numbers. It is concluded that multistep adenoma-adenocarcinoma progression was partially reflected in DNA ploidy pattern from hyperplastic polyps to villous adenomas. In adenocarcinomas, the Dukes classification paralleled well the DNA ploidy status from stage A diploid to stage D aneuploid, but was not accompanied by increasing PCNA-positive cell numbersPublication Open Access Sıçanlarda whey proteini ile oluşturulan glutatyon önkoþullandırmasının karaciğer sıcak iskemi/reperfüzyon hasarında hem oksijenaz-1 sistemi üzerine etkisi(2008-09-01) GÜLLÜOĞLU, MAHMUT BAHADIR; ÇELİKEL, ÇİĞDEM; Manukyan M. N., Yavuz Y., Erbarut I., Ogunc A. V., Ataizi-Celikel Ç., Yalcin A. S., GÜLLÜOĞLU M. B.Purpose: Oxygen radicals which are produced during reperfusion phase play a central role for hepatocellular damage during ischemia/reperfusion (I/R) injury. Antioxidant strategies appear a promising approach to prevent I/R injury. In the present study, the effect of glutathione (GSH) preconditioning established by whey protein feeding on hepatocellular injury markers was assessed in a rat hepatic normothermic I/R injury model. The interaction between intracellular GSH content and heme oxygenase-1 (HO-1) enzyme expression was also determined in order to understand the level of upgrading of HO-1 system in a high GSH content environment after preconditioning.