Person: ÇELİKEL, ÇİĞDEM
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ÇELİKEL
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ÇİĞDEM
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Publication Metadata only Comparison of different chronic hepatitis scores with respect to interobserver variability: A study of Turkish National Working Group of Hepato-pancreato-biliary Pathology(2007-08-01) ÇELİKEL, ÇİĞDEM; YILMAZ BARBET F., Akarca U. S., Akyol G., Celikel Ç., Erden E., Nart D., Sokmensuer C., Ozbay G.Publication Metadata only Effects of pentoxifylline on tnf-alpha production by peripheral blood mononuclear cells in patients with nonalcoholic steatohepatitis(2006-04-01) ÇELİKEL, ÇİĞDEM; Duman D. G., Ozdemir F., Birben E., Keskin O., Demiralp E., Celikel Ç., Kalayci O., Kalayci C.Publication Metadata only Is there a role for adipocytokines on the effect of anti-TNF treatment in an experimental model of colitis(2008-04-01) ÇELİKEL, ÇİĞDEM; Yapali S., Deniz M., EREN F., Imeryuz N., Celikel Ç., Ozkan N., Tahan V., Hamzaoglu H. O., Tozun N.Publication Open Access Stage IV Hodgkin's disease presenting with spinal epidural involvement and cauda equina compression as the initial manifestation: Case report(1997-10-01) ÇELİKEL, ÇİĞDEM; Toprak A., Kodalli N., Alpdogan T., Giral A., Celikel Ç., Gurmen N., Bayik M.Hodgkin\"s disease very rarely presents clinically, initially with a paraspinal mass, but this should be considered in the differential diagnosis. A patient presenting with back pain was diagnosed to have Stage IV Hodgkin\"s disease. MRI revealed an extradural and intraspinal soft tissue mass with bone infiltration. The importance of MRI in the early evaluation of a paraspinal mass and in determining the extent of the disease is emphasized.Publication Metadata only Does eradication of H-pylori reduce low dose aspirin induced gastroduodenal injury(1997-04-01) ÇELİKEL, ÇİĞDEM; Giral A., Ozdogan O., Celikel Ç., Ulusoy N., Tozun N., Kalayci C.Publication Metadata only Microalbuminuria in nondiabetic patients with nonalcoholic fatty liver disease: Association with liver fibrosis(2010-05-01) ÇELİKEL, ÇİĞDEM; YILMAZ Y., Alahdab Y. O., Yonal O., Kurt R., Kedrah A. E., Celikel Ç., Duman D., Ozdogan O., Imeryuz N., Avsar E., et al.Publication Open Access Evaluation of mucosal status in the follow-up of pediatric patients with celiac disease: the role of serology(2022-09-01) AY, NADİYE PINAR; ERTEM ŞAHİNOĞLU, DENİZ; ÇELİKEL, ÇİĞDEM; Sengul O. K., Akkelle B. S., Ay P., Volkan B., Tutar E., Celikel Ç., Ertem D.Recent guidelines suggest non-biopsy serology-based approach for the diagnosis of celiac disease; however, there is no evidence-based data regarding noninvasive follow-up of mucosal healing. The aim of this study is to investigate the efficacy of serology in reflecting mucosal status in the follow-up of pediatric patients with celiac disease. This is a validation study conducted at a university hospital. Patients who had biopsy proven celiac disease (Marsh III) at diagnosis, and had been followed-up for at least 12 months, were prospectively evaluated with duodenal biopsies. tTG-IgA and EMA tests were performed on the day of endoscopy. One hundred four patients with a mean age of 7.4 +/- 4.02 years were included in the study. The sensitivity and specificity of tTG-IgA were 85.2% and 61% respectively, with a high negative predictive value (NPV) of 92.2% but a very low positive predictive value (PPV) of 43.4%. We found that a cutoff value of 68.5 U/mL for tTG-IgA had a sensitivity, specificity of 85.2% and 85.7% respectively. The AUC was 0.891. The sensitivity and specificity of EMA was 77.8% and 87% respectively, with a high NPV of 91.8% but low PPV of 67.7%.Publication Metadata only Non-alcoholic fatty liver disease (NAFDL) - a retrospective study in paediatric liver biopsies(2019-09-01) OĞUZSOY, TUBA; ÇELİKEL, ÇİĞDEM; Oguzsoy T., Ozkan H. S., ÇELİKEL Ç.Publication Metadata only Flow cytometric DNA studies and AgNOR counts in patients with transitional cell carcinoma of the bladder(1995-01-01) ÇELİKEL, ÇİĞDEM; ÇELİKEL Ç., Dillioglugil O., Turkeri L., Basaran M., Yalciner A., Kullu S., Akdas A.Flow cytometry appears to be a promising diagnostic method which may influence the therapeutic approach to transitional cell carcinoma (TCC) of the bladder. The number of silver-stained nuclear organizer regions (AgNORs) seems to correlate with the growth fractions of the cells. In this study, we report the results of combined flow cytometric analysis and AgNOR in 37 patients with TCC of the bladder. A positive correlation was observed in the histological grade, stage and growth pattern in relation to the ploidy of tumors. There were statistically significant differences among the mean AgNOR counts of the different groups as defined by DNA content, histological grade, growth pattern and disease outcome. In different stage groups, the AgNOR counts were related both to recurrence and progression. It was concluded that AgNOR counts performed on routine formalin-fixed paraffin sections furnish significant kinetic information. According to our preliminary results AgNOR counts and the DNA content of the tumors should also be measured to decide on more aggressive treatment in some cases.Publication Open Access Prognostic significance of metastatic lymph node ratio in gastric cancer: a Western-center analysis(2023-08-01) UPRAK, TEVFİK KIVILCIM; AKIN, MUHAMMED İKBAL; ÇELİKEL, ÇİĞDEM; YEGEN, ŞEVKET CUMHUR; ERGENÇ, MUHAMMER; Ergenç M., Uprak T. K., Akın M. İ., Hekimoğlu E. E., Çelikel Ç., Yegen Ş. C.BackgroundTumor-node-metastasis (TNM) staging is the central gastric cancer (GC) staging system, but it has some disadvantages. However, the lymph node ratio (LNR) can be used regardless of the type of lymphadenectomy and is considered an important prognostic factor. This study aimed to evaluate the relationship between LNR and survival in patients who underwent curative GC surgery.MethodsAll patients who underwent radical gastric surgery between January 2014 and June 2022 were retrospectively evaluated. Clinicopathological features of tumors, TNM stage, and survival rates were analyzed. LNR was defined as the ratio between metastatic lymph nodes and total lymph nodes removed. The LNR groups were classified as follows: LNR0 = 0, 0.01 < LNR1 ≤ 0.1, 0.1 < LNR2 ≤ 0.25 and LNR3 > 0.25. Tumor characteristics and overall survival (OS) of the patients were compared between LNR groups.ResultsAfter exclusion, 333 patients were analyzed. The mean age was 62 ± 14years. According to the LNR classification, no difference was found between groups regarding age and sex. However, TNM stage III disease was significantly more common in LNR3 patients. Most patients (43.2%,n = 144) were in the LNR3 group. In terms of tumor characteristics (lymphatic, vascular, and perineural invasion), the LNR3 group had significantly poorer prognostic factors. The Cox regression model defined LNR3, TNM stage II—III disease, and advanced age as independent risk factors for survival. Patients with LNR3 demonstrated the lowest 5-year OS rate (35.7%) (estimated mean survival was 30 ± 1.9months) compared to LNR 0–1–2.ConclusionOur study showed that a high LNR was significantly associated with poor OS in patients who underwent curative gastrectomy. LNR can be used as an independent prognostic predictor in GC patients.
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