Person: EKREN, NAZMİ
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EKREN
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NAZMİ
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Publication Metadata only Fabrication and characterization of pla/sa/ha composite nanofiber by electrospinning for bone tissue engineering applications(2018-07-18) CESUR, SÜMEYYE; EKREN, NAZMİ; KILIÇ, OSMAN; OKTAR, FAİK NÜZHET; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; GÜNDÜZ, OĞUZHAN; Cesur S., Ekren N., Kılıç O., Oktar F. N., Bilğiç Alkaya D., Ayaz Seyhan S., Ege Z. R., Gündüz O.Publication Open Access A drug-eluting nanofibrous hyaluronic acid-keratin mat for diabetic wound dressing(2022-01-01) EKREN, NAZMİ; GÜNDÜZ, OĞUZHAN; Su S., Bedir T., KALKANDELEN C., Sasmazel H. T. , Basar A. O. , Chen J., EKREN N., GÜNDÜZ O.© 2022, Qatar University and Springer Nature Switzerland AG.Diabetes mellitus is a chronic metabolic disease associated with long-term multisystem complications, among which are non-healing diabetic foot ulcers (DFUs). Electrospinning is a sophisticated technique for the preparation of polymeric nanofibers impregnated with drugs for wound healing, burns, and diabetic ulcers. This study describes the fabrication and characterization of a novel drug-eluting dressing made of core–shell structured hyaluronic acid (HA)–keratin (KR)-polyethylene oxide (PEO) and polycaprolactone (PCL) nanofibers to treat diabetic wounds. The core–shell nanofibers produced by the emulsion electrospinning technique provide loading of metformin hydrochloride (MH), HA, and KR in the core of nanofibers, which in return improves the sustained long term release of the drug and prolongs the bioactivity. Morphological and chemical properties of the fibers were examined by SEM, FTIR, and XRD studies. It was observed that the fibers which contain HA and KR showed thin fiber structure, greater swelling capacity, fast degradation and increased cumulative drug release amount than neat emulsion fibers due to the hydrophilic nature of HA and KR. MH showed a sustained release from all fiber samples over 20 days and followed the first-order and Higuchi model kinetics and Fickian diffusion mechanism according to kinetic analysis results. In vitro cell culture studies showed that the developed mats exhibited enhanced biocompatibility performance with HA and KR incorporation. The results show that HA and KR-based emulsion electrospun fiber mats are potentially useful new nanofiber-based biomaterials in their use as drug carriers to treat diabetic wounds.Publication Open Access Marine-derived bioceramics for orthopedic, reconstructive and dental surgery applications(2022-11-01) OKTAR, FAİK NÜZHET; ÜNAL YILDIRIM, SEMRA; GÜNDÜZ, OĞUZHAN; EKREN, NAZMİ; ALTAN, ERAY; OKTAR F. N. , Unal S., GÜNDÜZ O., Ben Nissan B., Macha I. J. , Akyol S., Duta L., EKREN N., ALTAN E., YETMEZ M.Bioceramics are a fast-growing materials group, which are widely used in orthopedics, maxillofacial, dental, and reconstructive surgeries. They are produced using raw materials either from synthetic or natural sources. As naturally originated resources, the bones of sheep and cows are used after converting to calcium phosphates. Human-originated sources in the past were obtained from human cadaver bones, however now-a-days this has been discontinued. On the other hand, the \"golden standard\" in the reconstruction surgery has been using patients own bones, -i.e., autogenous bones, which heal better than other alternatives. Besides natural products, synthetic materials are produced from a range of inorganic raw and natural materials based on marine sources, such as corals, and other marine-derived materials (i.e., seashells, nacre). These are used to produce bioceramics and hence implants, devices, and bone grafts. Although during the last four decades a number of excellent books and book chapters have been published, no comprehensive review has been yet reported to cover the available marine materials and to indicate the related work and corresponding references to allow for both medical and ceramic scientists to access directly and open new avenues for further research on marine structures and their applications in orthopedic, maxillofacial, and reconstructive surgery areas. Hence, this review covers the general marine structures, their locations and availability in different countries and, current research on production methods of these unique structures that are difficult to fabricate synthetically. The authors are confident that this comprehensive review will be an excellent source not only for the ceramists, but also for the medical scientists.Publication Metadata only Fabrication and characterization of hazelnut shellpowder with reinforced polymer compositenanofibers(2018-09-14) KARTAL, İLYAS; OKTAR, FAİK NÜZHET; EKREN, NAZMİ; İNAN, AHMET TALAT; GÜNDÜZ, OĞUZHAN; CESUR, SÜMEYYE; Şengör İ., Cesur S., Kartal İ., Oktar F. N., Ekren N., İnan A. T., Gündüz O.Publication Metadata only Advances in 3D hydrogel matrix and their role in neural tissue engineeringg(CRC, New York , 2023-09-01) CESUR, SÜMEYYE; EKREN, NAZMİ; GÜNDÜZ, OĞUZHAN; Cesur S., Bedir T., Ekren N., Gündüz O., Üstündağ C. B.Publication Metadata only Production of the go-doped pla-based nanofibers and investigation of their electrical properties(2018-07-18) TERZİ, ÜMİT KEMALETTİN; KORKMAZ, HAYRİYE; EKREN, NAZMİ; GÜNDÜZ, OĞUZHAN; CESUR, SÜMEYYE; Özen S., Aydoğdu M. O., Ege Z. R., Cesur S., Terzi Ü. K., Korkmaz H., Ekren N., Gündüz O.Publication Metadata only Polylactic acid/Sodyum Alginate/Orange Oyster Shell based nanofiber composite design(2018-11-08) UZUN, MUHAMMET; EKREN, NAZMİ; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; CESUR, SÜMEYYE; Uzun M., Cesur S., Ekren N., Oktar F. N., Gündüz O.