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EKREN, NAZMİ

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EKREN

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NAZMİ

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Subject: Agricultural Sciences ×

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Now showing 1 - 2 of 2
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    PublicationOpen Access
    A drug-eluting nanofibrous hyaluronic acid-keratin mat for diabetic wound dressing
    (2022-01-01) EKREN, NAZMİ; GÜNDÜZ, OĞUZHAN; Su S., Bedir T., KALKANDELEN C., Sasmazel H. T. , Basar A. O. , Chen J., EKREN N., GÜNDÜZ O.
    © 2022, Qatar University and Springer Nature Switzerland AG.Diabetes mellitus is a chronic metabolic disease associated with long-term multisystem complications, among which are non-healing diabetic foot ulcers (DFUs). Electrospinning is a sophisticated technique for the preparation of polymeric nanofibers impregnated with drugs for wound healing, burns, and diabetic ulcers. This study describes the fabrication and characterization of a novel drug-eluting dressing made of core–shell structured hyaluronic acid (HA)–keratin (KR)-polyethylene oxide (PEO) and polycaprolactone (PCL) nanofibers to treat diabetic wounds. The core–shell nanofibers produced by the emulsion electrospinning technique provide loading of metformin hydrochloride (MH), HA, and KR in the core of nanofibers, which in return improves the sustained long term release of the drug and prolongs the bioactivity. Morphological and chemical properties of the fibers were examined by SEM, FTIR, and XRD studies. It was observed that the fibers which contain HA and KR showed thin fiber structure, greater swelling capacity, fast degradation and increased cumulative drug release amount than neat emulsion fibers due to the hydrophilic nature of HA and KR. MH showed a sustained release from all fiber samples over 20 days and followed the first-order and Higuchi model kinetics and Fickian diffusion mechanism according to kinetic analysis results. In vitro cell culture studies showed that the developed mats exhibited enhanced biocompatibility performance with HA and KR incorporation. The results show that HA and KR-based emulsion electrospun fiber mats are potentially useful new nanofiber-based biomaterials in their use as drug carriers to treat diabetic wounds.
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    PublicationOpen Access
    A Hydrophobic antireflective and antidust coating with $\text{SiO}_2$ and $\text{TiO}_2$ nanoparticles using a new 3-D printing method for photovoltaic panels
    (2022-07-01) EKREN, NAZMİ; SAĞLAM, ŞAFAK; Ekren N., Sarkin A. S., Sağlam Ş.
    The main outdoor factors that reduce the efficiency of the photovoltaic (PV) panel are the reflection and refraction of light, dirt, dust, and organic waste accumulating on the panel surface. In this article, an antireflection, self-cleaning coating was applied on the PV panel cover glass with a new method. With the coating, the surface has been given a hydrophobic feature. As a coating method, a 3-D printer has not been seen in the literature and used as a new method. The electrospinning method has also been tried as an alternative method. Solutions in different combinations were developed using polylactic acid or polymethylmethacrylate polymer, chloroform ($\text{CHCl}_3$) as a solvent, and silicon dioxide ($\text{SiO}_2$) and titanium dioxide ($\text{TiO}_2$) nanoparticles as primary materials in a modified 3-D printer for bioprinting. Five PV panels were obtained by applying different 3-D parameters from three solutions, which have the best results. Coating thicknesses are in the range of 3.12-8.47 mu m. Coated and uncoated PV panels were tested in outdoor conditions for ten-day periods. The power outputs of the PV panels were measured, and their ten-day average efficiency was presented. According to the results, the highest efficiency increase is 8.7%. The highest light transmittance is 88.2% at 550 nm. In addition, hydrophobic properties were observed on all surfaces and the water contact angle was measured as 96.18 degrees.