Person: SAKALLI KANİ, AYŞE
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SAKALLI KANİ
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AYŞE
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Publication Metadata only The Effect of Dream Anxiety on Sleep Quality in Inflammatory Bowel Diseases(KARGER, 2020) SAKALLI KANİ, AYŞE; Kani, Haluk Tarik; Kani, Ayse Sakalli; Dural, Uzay; Basgoze, Emre; Aksu, Cagri; Kahraman, Merve Meric; Alahdab, Yesim Ozen; Atug, Ozlen; Kuscu, Kemal; Imeryuz, NeseIntroduction:Declining sleep quality is a well-known issue in inflammatory bowel disease (IBD), but dream characteristics of patients with IBD and their role in sleep quality are unknown. In this study, we aimed to examine whether and how patients with ulcerative colitis (UC) and Crohn's disease (CD) differ on sleep quality, sleepiness level, and dream anxiety (DA) level compared to healthy controls (HC), controlling for their depressive and anxious tendencies.Methods:Patients and HCs were enrolled prospectively into the study. The Van DA Scale, Pittsburg Sleep Quality Index, Epworth Sleepiness Scale, Beck Depression Index, and State-Trait Anxiety Inventories were used to assess DA, sleep quality, sleepiness, depression, and anxiety, respectively.Results:Patients with IBD had significantly lower depression (p= 0.004), state anxiety (p= 0.0001), trait anxiety (p= 0.004), and DA (p= 0.0001) than HCs. Although no statistically significant difference in sleep quality was found (p= 0.99), daytime sleepiness was more common in HCs than in IBD patients (p = 0.0001). No statistically significant difference was seen in depression, state anxiety, trait anxiety, DA, sleep quality, and daytime sleepiness between patients with CD and those with UC. No correlation was found between disease activity indices and psychological parameters.Conclusion:In contrast to previous studies, this study found lower anxiety and depression levels in patients with IBD than in HCs. Moreover, DA score was higher in HCs. For the first time, we revealed that DA may be one of the factors leading to sleep disturbance in patients with IBD.Publication Open Access Exploring the role of adult attachment, major depression and childhood trauma in arterial stiffness: A preliminary study(2023-08-01) SAKALLI KANİ, AYŞE; ÇİNÇİN, AHMET ALTUĞ; ÖZERCAN, AHMET; TOPÇUOĞLU, VOLKAN; SAYAR, MUSTAFA KEMAL; SAKALLI KANİ A., Çinçin A., ÖZERCAN A., Şenoğuz U. D., Örnek E., DOKUZ G., TOPÇUOĞLU V., Sayar K.Objective: Prior research indicates a noteworthy and intricate connection between depression and subclinical atherosclerosis. Nevertheless, the biological and psychological mechanisms that underlie this association are not yet fully understood. To address this gap, this exploratory study aimed to examine the relationship between active clinical depression and arterial stiffness (AS), with a particular focus on the potential mediating roles of attachment security and childhood trauma. Methods: In this cross-sectional study, we examined 38 patients with active major depression free of dyslipidemia, diabetes mellitus, hypertension, and obesity and 32 healthy controls. All participants underwent blood tests, psychometric assessments, and AS measurements using the Mobil-O-Graph arteriograph system. AS severity was evaluated using an augmentation index (AIx) normalized to 75 beats/min. Results: In the absence of defined clinical cardiovascular risk factors, there was no significant difference in AIx between individuals with depression and healthy controls (p = .75). Patients with longer intervals between depressive episodes had lower AIx (r = −0.44, p < .01). Insecure attachment and childhood trauma did not significantly associate with AIx in patients. Whereas insecure attachment was positively correlated with AIx only in healthy controls (r = 0.50, p = 01). Conclusions: Our analysis of established risk factors for atherosclerosis revealed that depression and childhood trauma had no significant relationship with AS. However, we did identify a novel finding: insecure attachment was significantly associated with AS severity in healthy adults without defined cardiovascular risk factors for the first time. To our knowledge, this is the first study to demonstrate this relationship.Publication Open Access Depression and anxiety have unique contributions to somatic complaints in depression, irritable bowel syndrome and inflammatory bowel diseases(TAYLOR & FRANCIS LTD, 2019-10-02) SAKALLI KANİ, AYŞE; Yanartas, Omer; Kani, Haluk Tarik; Kani, Ayse Sakalli; Akca, Zeynep Nur Demirok; Akca, Erdogdu; Ergun, Serhat; Tezcan, Neslihan; Atug, Ozlen; Imeryuz, Nese; Sayar, KemalOBJECTIVE: In this study we aim to investigate the effects of somatic and related symptoms (SARS), alexithymia, hypochondriasis, anxiety and depression on patients with major depressive disorder, irritable bowel syndrome, inflammatory bowel disease which are the representative diseases of brain gut axis (BGA). METHOD: Sex and age similar groups of participants with major depressive disorder (MDD) (n = 102), irritable bowel syndrome (IBS) (n = 51), inflammatory bowel diseases (IBDs) (n = 54), and control group (n = 67) were included into this study. Depression and IBS were diagnosed according to DSM-5 and ROME 4 criteria, respectively. IBDs were established according to endoscopic, histological, and radiographic investigations. In all participants, somatic and related symptoms were evaluated by self-report scales including Bradford Somatic Inventory (BSI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Whiteley Index (WI), The 20-item Toronto Alexithymia Scale (TAS-20), Somatosensory Amplification Scale (SAS). RESULTS: BSI, BDI, BAI, WI, TAS-20 and SAS scores were found to be highest in patients with MDD; scores of patients with IBS and IBDs were similar but higher than the control group. Gastrointestinal somatic symptoms including nausea, stomach burning, abdominal ache and stomach swelling were observed in more than half of the patients with MDD. The most common extra-intestinal somatic symptoms were, headache and neck pain and/or tension, and leg pain in IBS patients. However leg pain, weakness and lack of energy, and neck pain/tension were highest in IBDs patients. While the strongest correlation determined was between the BSI and anxiety scores in MDD (p<.001, r = .688) and IBS group; (p<.001, r = .51), in IBDs patients, BSI scores were more significantly correlated with depressive scores instead of anxiety (p<.001, r = .712 vs. r = .705, p<.001). CONCLUSION: Our study demonstrates that SARS are commonly observed in the representative diseases of BGA. Extra-intestinal somatic symptoms are common in IBS, and IBDs, and also gastrointestinal somatic symptoms are common in patients with MDD. Assessment of somatic and related symptoms is quite important in the context of BGA.