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SAKALLI KANİ, AYŞE

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Author: TOPÇUOĞLU, VOLKAN × Subject: Clinical Medicine (MED) ×

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    PublicationOpen Access
    Does chronobiological preference affect the clinical appearance of obsessive-compulsive disorders
    (2023-01-01) SAKALLI KANİ, AYŞE; TOPÇUOĞLU, VOLKAN; SAYAR, MUSTAFA KEMAL; SAKALLI KANİ A., DURAL ŞENOĞUZ U., TOPÇUOĞLU V., Sayar K.
    Objective: There is a growing body of evidence support-ing the involvement of circadian rhythm abnormalities in the psychopathology of obsessive-compulsive disorder. However, the effects of chronotype preference on the clinical features of this disorder are elusive. The aim of this study is to investigate how chronobiological predis-positions of people with obsessive compulsive disorder affect obsessive compulsive disorder symptomatology, age of onset, course of the disease and accompanying comorbid conditions. Method: Within this cross-section-al study, 76 participants with mean age of 32.53, who have been under treatment with a diagnosis of obses-sive-compulsive disorder, were evaluated. Sociodemographic and clinical data form, Yale-Brown Obsessive Compulsive Scale, Morningness and Eveningness Questionnaire, Hamilton Depression Rating Scale, and Hamilton Anxiety Scale were applied to the participants. Results: 65.8% (n=50) of the participants consisted of women. Mean age of onset is 18.74 +/- 9.36 years. Most of the patients were reactive type (n=47, 61,8 %). Most common obsession type was contamina-tion (n=53, %69,74), the most common compulsion type was cleaning/washing (n=52, %68,42). There was no significant correlation between morningness and eveningness scale scores and obsession and compulsion types. No significant correlation was found between morningness and eveningness scale scores and OCD onset age. There was no significant difference between morningness and eveningness scale scores according to the OCD type of the patients and the presence of accom-panying clinical diagnoses. Discussion: Morningness or eveningness chronotype tendencies did not have a sig-nificant impact on the clinical appearance of OCD.
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    PublicationOpen Access
    Exploring the role of adult attachment, major depression and childhood trauma in arterial stiffness: A preliminary study
    (2023-08-01) SAKALLI KANİ, AYŞE; ÇİNÇİN, AHMET ALTUĞ; ÖZERCAN, AHMET; TOPÇUOĞLU, VOLKAN; SAYAR, MUSTAFA KEMAL; SAKALLI KANİ A., Çinçin A., ÖZERCAN A., Şenoğuz U. D., Örnek E., DOKUZ G., TOPÇUOĞLU V., Sayar K.
    Objective: Prior research indicates a noteworthy and intricate connection between depression and subclinical atherosclerosis. Nevertheless, the biological and psychological mechanisms that underlie this association are not yet fully understood. To address this gap, this exploratory study aimed to examine the relationship between active clinical depression and arterial stiffness (AS), with a particular focus on the potential mediating roles of attachment security and childhood trauma. Methods: In this cross-sectional study, we examined 38 patients with active major depression free of dyslipidemia, diabetes mellitus, hypertension, and obesity and 32 healthy controls. All participants underwent blood tests, psychometric assessments, and AS measurements using the Mobil-O-Graph arteriograph system. AS severity was evaluated using an augmentation index (AIx) normalized to 75 beats/min. Results: In the absence of defined clinical cardiovascular risk factors, there was no significant difference in AIx between individuals with depression and healthy controls (p = .75). Patients with longer intervals between depressive episodes had lower AIx (r = −0.44, p < .01). Insecure attachment and childhood trauma did not significantly associate with AIx in patients. Whereas insecure attachment was positively correlated with AIx only in healthy controls (r = 0.50, p = 01). Conclusions: Our analysis of established risk factors for atherosclerosis revealed that depression and childhood trauma had no significant relationship with AS. However, we did identify a novel finding: insecure attachment was significantly associated with AS severity in healthy adults without defined cardiovascular risk factors for the first time. To our knowledge, this is the first study to demonstrate this relationship.