Person: SAKALLI KANİ, AYŞE
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SAKALLI KANİ
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AYŞE
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Publication Open Access The impact of childhood trauma and daily life experiences on emotional and psychotic symptom intensity in psychosis: An experience sampling study(2022-11-01) SAKALLI KANİ, AYŞE; DOKUZ G., SAKALLI KANİ A., Uysal O., Kuscu M. K.Adverse childhood experiences create vulnerability to psychosis through biological and cognitive changes, and that may be observed as an increased emotional and psychotic response to daily life experiences in adulthood. This study aims to examine the effects of childhood maltreatment on psychotic patients\" daily stress and emotional and psychotic intensity related to various experiences throughout the day. Daily activities and events, and emotional and psychotic intensity of forty-one psychotic patients were assessed with the Experience Sam-pling Method. The Childhood Trauma Questionnaire (CTQ) was used to evaluate childhood adversities. Multi-level regression analyses showed that all trauma subtypes, except for sexual abuse, were associated with increased psychosis and event-stress. Emotional maltreatment was the most associated trauma type with high negative and low positive affect and increased daily stress. Patients reported the highest stress and negative affect related to internal experiences but the lowest stress related to recreational actions. Social activities were also associated with higher positive affect and lower stress and psychosis, with the high CTQ group having greater stress in those activities. Our study demonstrates the negative impact of childhood trauma, especially emotional maltreatment, on daily stress and emotional and psychotic intensity in psychotic patients via different daily experiences.Publication Open Access Does chronobiological preference affect the clinical appearance of obsessive-compulsive disorders(2023-01-01) SAKALLI KANİ, AYŞE; TOPÇUOĞLU, VOLKAN; SAYAR, MUSTAFA KEMAL; SAKALLI KANİ A., DURAL ŞENOĞUZ U., TOPÇUOĞLU V., Sayar K.Objective: There is a growing body of evidence support-ing the involvement of circadian rhythm abnormalities in the psychopathology of obsessive-compulsive disorder. However, the effects of chronotype preference on the clinical features of this disorder are elusive. The aim of this study is to investigate how chronobiological predis-positions of people with obsessive compulsive disorder affect obsessive compulsive disorder symptomatology, age of onset, course of the disease and accompanying comorbid conditions. Method: Within this cross-section-al study, 76 participants with mean age of 32.53, who have been under treatment with a diagnosis of obses-sive-compulsive disorder, were evaluated. Sociodemographic and clinical data form, Yale-Brown Obsessive Compulsive Scale, Morningness and Eveningness Questionnaire, Hamilton Depression Rating Scale, and Hamilton Anxiety Scale were applied to the participants. Results: 65.8% (n=50) of the participants consisted of women. Mean age of onset is 18.74 +/- 9.36 years. Most of the patients were reactive type (n=47, 61,8 %). Most common obsession type was contamina-tion (n=53, %69,74), the most common compulsion type was cleaning/washing (n=52, %68,42). There was no significant correlation between morningness and eveningness scale scores and obsession and compulsion types. No significant correlation was found between morningness and eveningness scale scores and OCD onset age. There was no significant difference between morningness and eveningness scale scores according to the OCD type of the patients and the presence of accom-panying clinical diagnoses. Discussion: Morningness or eveningness chronotype tendencies did not have a sig-nificant impact on the clinical appearance of OCD.Publication Metadata only Dream anxiety, chronotype and dipping pattern in hypertensive patients assessed with 24 h ambulatory blood pressure monitoring(SPRINGER JAPAN KK, 2016) SAKALLI KANİ, AYŞE; Kani, Ayse Sakalli; Sunbul, Murat; Kani, Haluk Tarik; Yanartas, Omer; Tezcan, Neslihan; Emul, MuratThe purpose of the present study was to investigate dream anxiety, impulsivity, and chronotypes in patients with dipper/non-dipper hypertension and to compare with healthy controls. Sixty-two patients diagnosed with hypertension and 33 healthy individuals were recruited in this study. A history of current psychiatric illness or psychotropic drug usage, significant cardiac, medical or neurological disease and pregnancy were the exclusion criterias for the study. All patients and healthy controls underwent 24-h ambulatory blood pressure monitoring. The Van Dream Anxiety Scale, Morningness-Eveningness Questionnaire, Spielberger State-Trait Anxiety Inventory, Beck Depression Inventory, Barratt Impulsivity Scale and Pittsburgh Sleep Quality Index were administered to all participants. There were two groups; patients with hypertension (dipper, n = 26 and non-dipper, n = 36) and healthy controls (n = 33). No differences between groups among gender (chi(2) = 4.42 and p = 0.110) and mean age (F = 0.239 and p = 0.795) were found. In patients with hypertension; dream anxiety, impulsivity, depression and trait anxiety scores were significantly higher than healthy controls. Sleep quality was poorer in patients with hypertension and there was no difference according to chronotype between patients and controls. There were no differences between dipper and non-dipper groups according to dream anxiety, sleep quality, impulsivity, state-trait anxiety, and depressive scores. In conclusion, dream anxiety is a previously unaddressed psychological entity that, in addition to anxiety, depression, impulsivity and poorer sleep quality, appears in hypertensive patients. Longitudinal studies with larger sample sizes would be valuable to elucidate the relationship between dream anxiety and hypertension patterns.Publication Open Access Neuropsychological and clinical correlations of optical coherence tomography findings in patients with schizophrenia(2023-10-01) SAKALLI KANİ, AYŞE; ŞAHİN ÇAM, CANSUN; AKKAYA TURHAN, SEMRA; TOKER, AYŞE EBRU; YILDIZ, MESUT; Sakallı Kani A., Şahin Çam C., Çelik E. B., Dural Şenoğuz U., Duran M., Akkaya Turhan S., Toker A. E., Yıldız M.Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters. Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters. Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior (ρ = – .422, p <.05). STROOP response duration positively correlated with right RNFL on average (ρ = .551, p <.05), left RNFL on average (ρ = .498, p <.05), right RNFL superior (ρ = .507, p <.05), left RNFL superior (ρ = .461, p <.05) and right RNFL temporal values (ρ = .434, p <.05). STROOP response error was also positively correlated with right RNFL temporal thickness (ρ = .430, p <.05). STROOP response duration was positively correlated with right GCL total (ρ = .646, p <.01), right GCL superior (ρ = .658, p <.01) and right GCL inferior (ρ = .596, p <.01) thickness. Conclusion: We did not find a significant relationship between reduced RNFL or GCL thickness and cognitive impairment. However, we had several positive correlations between cognitive task scores and RNFL and GCL thicknesses. Additionally, our study did not correlate symptom severity and clinical severity parameters with reduced RNFL or GCL thicknessPublication Open Access The role of affective temperaments and chronotype in pharmacotherapy response in patients with obsessive-compulsive disorder(TAYLOR & FRANCIS LTD, 2018-01-02) SAKALLI KANİ, AYŞE; Kani, Ayse Sakalli; Poyraz, Cana Aksoy; Poyraz, B. Cagri; Bayar, M. Reha; Akin, Ercan; Kose, SametBACKGROUND: Comorbid mood disorders affect the prognosis of obsessive-compulsive disorder (OCD) negatively. Affective temperaments are assumed to be subsyndromal symptoms and precursors of mood disorders, but its effects on OCD outcome still remain unclear. There is a body of evidence, which supports the association between circadian rhythm disturbances and mood disorders in the literature. In contrast, there is limited data concerning the effects of chronobiological differences among the patients with OCD and OCD comorbid mood disorders. The main objective of this present study was to examine the clinical effects of affective temperaments and chronotype differences in patients with OCD. METHODS: The study participants were 76 patients with OCD, who have been under treatment at least for 12 weeks, and 55 healthy controls. The participants were administered the Yale-Brown Obsessive Compulsive Scale, Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire, Morningness and Eveningness Questionnaire, Hamilton Depression Rating Scale, and Hamilton Anxiety Scale. RESULTS: OCD patients scored higher in depressive, cyclothymic, irritable, and anxious temperament scores compared to the healthy controls. There were significant differences between patients with remission and not remission in depressive, cyclothymic, irritable, and anxious temperaments. Eveningness chronotype was more frequent in OCD patients; however, the difference was not statistically significant. CONCLUSIONS: Understanding the effects of affective temperaments and chronotype differences on the outcome of patients with OCD might provide valuable insights in developing new treatment approaches especially in treatment-resistant OCD cases.Publication Open Access Evaluation of depression, anxiety, alexithymia, attachment, social support and somatization in functional dyspepsia(TAYLOR & FRANCIS LTD, 2019-01-02) SAKALLI KANİ, AYŞE; Kani, Haluk Tarik; Dural, Uzay; Kani, Ayse Sakalli; Yanartas, Omer; Kiziltas, Safak; Enc, Feruze Yilmaz; Atug, Ozlen; Deyneli, Oguzhan; Kuscu, Kemal; Imeryuz, NeseAIM: The psychiatric and psychosocial aetiology of Functional dyspepsia is not well known. In the present study, our aim is to determine the relative contributions of psychiatric predictors - i.e. depression, anxiety, somatization, alexithymia - in relation with socio-psychological factors, specifically their personal characteristics (i.e. emotional attachment) and perceived social support, in distinguishing FD from organic dyspepsia and healthy samples. MATERIAL AND METHODS: An estimated 30 functional dyspepsia, 29 organic dyspepsia patients who were admitted to our gastroenterology outpatient clinic and 27 healthy controls were enrolled to our study. Beck Depression Inventory, Toronto Alexithymia Scale, Adult Attachment Scale, State-Trait Anxiety Inventory, Multidimensional Scale of Perceived Social Support and somatization sub-scale of Symptom Checklist-90 were provided to all patients and healthy controls. All participants were examined by a gastroenterologist and a psychiatrist. RESULTS: Healthy controls were younger than organic dyspepsia group and women/men rate was lower in organic dyspepsia than other two groups. Depression score was higher in functional dyspepsia group than in healthy controls and functional dyspepsia group's attachment syle was more secure than that of the healthy control group. Somatization rate was seen higher in functional dyspepsia group with psychiatric examination. There was no significant difference seen in anxiety, alexithymia and social support between the three groups. DISCUSSION: Anxious-avoidant attachment profile as well as the higher propensity to have depressive and anxiety symptoms might be critical psychiatric and psychosocial factors underlying FD's aetiology. A multidisciplinary approach is needed in the follow up of functional dyspepsia patients. Psychological evaluation and treatment would increase the life quality of dyspepsia patients.Publication Metadata only The Effect of Dream Anxiety on Sleep Quality in Inflammatory Bowel Diseases(KARGER, 2020) SAKALLI KANİ, AYŞE; Kani, Haluk Tarik; Kani, Ayse Sakalli; Dural, Uzay; Basgoze, Emre; Aksu, Cagri; Kahraman, Merve Meric; Alahdab, Yesim Ozen; Atug, Ozlen; Kuscu, Kemal; Imeryuz, NeseIntroduction:Declining sleep quality is a well-known issue in inflammatory bowel disease (IBD), but dream characteristics of patients with IBD and their role in sleep quality are unknown. In this study, we aimed to examine whether and how patients with ulcerative colitis (UC) and Crohn's disease (CD) differ on sleep quality, sleepiness level, and dream anxiety (DA) level compared to healthy controls (HC), controlling for their depressive and anxious tendencies.Methods:Patients and HCs were enrolled prospectively into the study. The Van DA Scale, Pittsburg Sleep Quality Index, Epworth Sleepiness Scale, Beck Depression Index, and State-Trait Anxiety Inventories were used to assess DA, sleep quality, sleepiness, depression, and anxiety, respectively.Results:Patients with IBD had significantly lower depression (p= 0.004), state anxiety (p= 0.0001), trait anxiety (p= 0.004), and DA (p= 0.0001) than HCs. Although no statistically significant difference in sleep quality was found (p= 0.99), daytime sleepiness was more common in HCs than in IBD patients (p = 0.0001). No statistically significant difference was seen in depression, state anxiety, trait anxiety, DA, sleep quality, and daytime sleepiness between patients with CD and those with UC. No correlation was found between disease activity indices and psychological parameters.Conclusion:In contrast to previous studies, this study found lower anxiety and depression levels in patients with IBD than in HCs. Moreover, DA score was higher in HCs. For the first time, we revealed that DA may be one of the factors leading to sleep disturbance in patients with IBD.Publication Open Access Exploring the role of adult attachment, major depression and childhood trauma in arterial stiffness: A preliminary study(2023-08-01) SAKALLI KANİ, AYŞE; ÇİNÇİN, AHMET ALTUĞ; ÖZERCAN, AHMET; TOPÇUOĞLU, VOLKAN; SAYAR, MUSTAFA KEMAL; SAKALLI KANİ A., Çinçin A., ÖZERCAN A., Şenoğuz U. D., Örnek E., DOKUZ G., TOPÇUOĞLU V., Sayar K.Objective: Prior research indicates a noteworthy and intricate connection between depression and subclinical atherosclerosis. Nevertheless, the biological and psychological mechanisms that underlie this association are not yet fully understood. To address this gap, this exploratory study aimed to examine the relationship between active clinical depression and arterial stiffness (AS), with a particular focus on the potential mediating roles of attachment security and childhood trauma. Methods: In this cross-sectional study, we examined 38 patients with active major depression free of dyslipidemia, diabetes mellitus, hypertension, and obesity and 32 healthy controls. All participants underwent blood tests, psychometric assessments, and AS measurements using the Mobil-O-Graph arteriograph system. AS severity was evaluated using an augmentation index (AIx) normalized to 75 beats/min. Results: In the absence of defined clinical cardiovascular risk factors, there was no significant difference in AIx between individuals with depression and healthy controls (p = .75). Patients with longer intervals between depressive episodes had lower AIx (r = −0.44, p < .01). Insecure attachment and childhood trauma did not significantly associate with AIx in patients. Whereas insecure attachment was positively correlated with AIx only in healthy controls (r = 0.50, p = 01). Conclusions: Our analysis of established risk factors for atherosclerosis revealed that depression and childhood trauma had no significant relationship with AS. However, we did identify a novel finding: insecure attachment was significantly associated with AS severity in healthy adults without defined cardiovascular risk factors for the first time. To our knowledge, this is the first study to demonstrate this relationship.Publication Open Access Depression and anxiety have unique contributions to somatic complaints in depression, irritable bowel syndrome and inflammatory bowel diseases(TAYLOR & FRANCIS LTD, 2019-10-02) SAKALLI KANİ, AYŞE; Yanartas, Omer; Kani, Haluk Tarik; Kani, Ayse Sakalli; Akca, Zeynep Nur Demirok; Akca, Erdogdu; Ergun, Serhat; Tezcan, Neslihan; Atug, Ozlen; Imeryuz, Nese; Sayar, KemalOBJECTIVE: In this study we aim to investigate the effects of somatic and related symptoms (SARS), alexithymia, hypochondriasis, anxiety and depression on patients with major depressive disorder, irritable bowel syndrome, inflammatory bowel disease which are the representative diseases of brain gut axis (BGA). METHOD: Sex and age similar groups of participants with major depressive disorder (MDD) (n = 102), irritable bowel syndrome (IBS) (n = 51), inflammatory bowel diseases (IBDs) (n = 54), and control group (n = 67) were included into this study. Depression and IBS were diagnosed according to DSM-5 and ROME 4 criteria, respectively. IBDs were established according to endoscopic, histological, and radiographic investigations. In all participants, somatic and related symptoms were evaluated by self-report scales including Bradford Somatic Inventory (BSI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Whiteley Index (WI), The 20-item Toronto Alexithymia Scale (TAS-20), Somatosensory Amplification Scale (SAS). RESULTS: BSI, BDI, BAI, WI, TAS-20 and SAS scores were found to be highest in patients with MDD; scores of patients with IBS and IBDs were similar but higher than the control group. Gastrointestinal somatic symptoms including nausea, stomach burning, abdominal ache and stomach swelling were observed in more than half of the patients with MDD. The most common extra-intestinal somatic symptoms were, headache and neck pain and/or tension, and leg pain in IBS patients. However leg pain, weakness and lack of energy, and neck pain/tension were highest in IBDs patients. While the strongest correlation determined was between the BSI and anxiety scores in MDD (p<.001, r = .688) and IBS group; (p<.001, r = .51), in IBDs patients, BSI scores were more significantly correlated with depressive scores instead of anxiety (p<.001, r = .712 vs. r = .705, p<.001). CONCLUSION: Our study demonstrates that SARS are commonly observed in the representative diseases of BGA. Extra-intestinal somatic symptoms are common in IBS, and IBDs, and also gastrointestinal somatic symptoms are common in patients with MDD. Assessment of somatic and related symptoms is quite important in the context of BGA.