Person: AYDEMİR, SEZGİN
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AYDEMİR
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SEZGİN
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Publication Metadata only Comparison of inhaled and intraperitoneal formaldehyde toxicity in rats and the evaluation of the effects of melatonin(ELSEVIER IRELAND LTD, 2016) BECEREN, AYFER; Aydemir, S.; Akgun, S. G.; Ozkan, N.; Yuksel, M.; Beceren, A.; Erdogan, N.; Omurtag, G. Z.Publication Metadata only The effect of carnitine against acrylamide-induced toxicity in rat lung and liver tissues(ELSEVIER IRELAND LTD, 2016) GÜÇLÜ, HÜLYA; Aydemir, S.; Guclu, H.; Ozkan, N.; Yuksel, M.; Erdogan, N.; Omurtag, G. Z.Publication Metadata only Evaluation of incision wound healing activity of Scorzonera veratrifolia in Wistar albino rats(ELSEVIER IRELAND LTD, 2017) BECEREN, AYFER; Gecim, Mert; Beceren, Ayfer; Aydemir, Sezgin; Sardas, SemraPublication Metadata only Antioxidant effects of UMCA (R) on acrylamide induced toxicity in rats(ELSEVIER IRELAND LTD, 2015) AYDEMİR, SEZGİN; Aydemir, S.; Sahin, H.; Ozkan, N.; Yuksel, M.; Erdogan, N.; Omurtag, G. Z.Publication Metadata only The wound healing effects of Nerium oleander extract against burn-induced oxidative injury(ELSEVIER IRELAND LTD, 2016) BECEREN, AYFER; Akgun, S. G.; Aydemir, S.; Ozkan, N.; Beceren, A.; Sardas, S.Publication Metadata only Antioxidant components of Viburnum opulus L. determined by on-line HPLC-UV-ABTS radical scavenging and LC-UV-ESI-MS methods(ELSEVIER SCI LTD, 2015) AYDEMİR, SEZGİN; Karacelik, Ayca Aktas; Kucuk, Murat; Iskefiyeli, Zeynep; Aydemir, Sezgin; De Smet, Seppe; Miserez, Bram; Sandra, PatrickAntioxidant activity of the juice and seed and skin extracts prepared with methanol, acetonitrile, and water of Viburnum opulus L. grown in Eastern Black Sea Region were studied with an on-line HPLC-ABTS method and off-line antioxidant methods, among which a linear positive correlation was observed. The fruit extracts were analysed with the HPLC-UV method optimised with 14 standard phenolics. Identification of the phenolic components in the juice was made using an HPLC-UV-ESI-MS method. Nineteen phenolic compounds in juice were identified by comparing the retention times and mass spectra with those of the standards and the phenolics reported in the literature. The major peaks in the juice belonged to coumaroyl-quinic acid, chlorogenic acid, procyanidin B2, and procyanidin trimer. Quite different antioxidant composition profiles were obtained from the extracts with the solvents of different polarities. The antioxidant activities of the seed extracts were higher than those of the skin extracts in general. (C) 2014 Elsevier Ltd. All rights reserved.Publication Metadata only Protective role of St. John's Wort on formaldehyde-induced lung tissue injury: Inhibiton of inflammation and oxidative stress mediated apoptosis(ELSEVIER IRELAND LTD, 2017) BECEREN, AYFER; Beceren, Ayfer; Aydemir, Sezgin; Ozakpinar, Ozlem Bingol; Sehirli, Ahmet Ozer; Omurtag, Gulden ZehraPublication Metadata only The role of St. John's Wort against formaldehyde toxicity induced by inhalation in rats(ELSEVIER IRELAND LTD, 2017) BECEREN, AYFER; Aydemir, Sezgin; Beceren, Ayfer; Gecim, Mert; Ozakpinar, Ozlem Bingol; Sehirli, Ahmet Ozer; Omurtag, Gulden ZehraPublication Open Access Evaluation of the wound healing potential of Aloe vera-based extract of Nerium oleander(KARE PUBL, 2017) YÜKSEL, MERAL; Akgun, Sevcan Gul; Aydemir, Sezgin; Ozkan, Naziye; Yuksel, Meral; Sardas, SemraOBJECTIVE: Nerium oleander (Apocynaceae) and Aloe vera (Liliaceae) are among the widely used herbal remedies for treating skin diseases and possess numerous activities such as antibacterial, antiviral, antifungal, and antioxidant. The aim of this study was to investigate the possible wound healing effect of Aloev era-based extract of the N. oleander leaf (NAE-8 (R)) based on its antioxidant, anti-inflammatory, and DNA repair capacity along with histological changes and to compare them with the traditional silver sulfadiazine treatment (SSD). METHODS: Twenty-four Wistar albino rats were randomly grouped as follows: i) control, ii) burn alone (burn), iii) burn with topical NAE-8 (R) (burn+ NAE-8 (R)) treatment, and iv) burn with topical 1% silver sulfadiazine (burn+ SSD) treatment. All groups received their related topical application twice a day for 14 consecutive days. Upon completion of the experimental protocol, trunk blood and skin tissues were collected for measuring malondialdehyde (MDA), glutathione (GSH), myeloperoxidase (MPO), tumor necrosis factor alpha (TNF-a), interleukin-1 beta (IL-1 beta), % DNA in the tail (% DNAT) levels along with histological examinations. RESULTS: Thermal injury-induced alterations in MDA, GSH, MPO, TNF-a, IL-1 beta, and % DNAT levels were significantly reversed by NAE-8 (R) treatment. These ameliorative effects were also supported by histological findings. CONCLUSION: Findings of the present study suggest that NAE-8 (R) is a promising remedy for treating skin burn injury.