Person: BİLGİLİ, BELİZ
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BİLGİLİ
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BELİZ
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Publication Open Access MSC transplantation in eight severe covid-19 patients: can cytokine storm be reversed(2020-05-01) BİLGİLİ, BELİZ; Bilgili B.Background: In this clinical case report, we evaluated the clinical and the efficacy outcomes of Mesenchymal Stem Cells (MSCs) transplantation in eight severe COVID-19 patients with pneumonia Methods: MSCs were administered to eight severe/critically severe patients, unresponsive to treatment algorithms patients were also reviewed without MSC transplantation. Results: could not achieve clinical improvement and passed away. In all eight patients, compared to the baseline, there was a significant decrease in CRP (p=0.036), fibrinogen (p=0.012) and Hb (p=0.03) values on post treatment day 5. While there was an increase in lymphocyte count between baseline and post treatment, the change didn’t reach statistical significance (p=0.06). There was no statistically significant change in ferritin, neutrophil count, respiratory rate, oxygen saturation, troponin and platelet count (p>0.05) between baseline and post-treatment day 5. Conclusion: Four patients were discharged from the ICU after MSC transplantation. Although there was an immediate significant improvement in their prognostic markers, the other four patients remained in critically severe condition and passed away. In two severe patients, the recovery was faster after MSC transplantation than the other two critically severe recovered patients. This may indicate the potential benefit of MSC transplantation performed in an earlier clinical stage. Moreover, we can advise MSC transplantation when the poor prognostic markers (decrease in lymphocyte number, increase in fibrinogen and CRP) are observed in the severe COVID-19 patients, to overcome alveolar damage due to “cytokine storm.” This observation may introduce an algorithm for a supportive treatment with MSC transplantation for COVID-19 patients, which needs to be confirmed by broader randomized controlled trials.Publication Metadata only Yoğun bakım ünitesinde konvelesan plazma kullanımının covid-19 hastalarında mortalite üzerindeki etkisi(2022-03-17) GÜL, FETHİ; BİLGİLİ, BELİZ; CİNEL, İSMAİL HAKKI; Sabah M. S., Gül F., Bilgili B., Kaplan S. T., Oktay B. D., Cinel İ. H.Publication Metadata only Yoğun bakım ünitesinde kültür örnekleri nasıl, ne zaman ve hangi sıklıkla alınmalıdır? Doğru değerlendiriyor muyuz(Akademisyen Yayınevi Kitabevi, 2023-05-01) BİLGİLİ, BELİZ; Bilgili B., Yiğit A. C.; Ekinci, Osman; Tavukçu Özkan, Sedef; Pekok, Abdullah UmutPublication Open Access The impact of the analgesic agents administered in recipients of liver transplants on graft results(2022-01-01) BİLGİLİ, BELİZ; A S., Çabakli G T., Y K., Bilgili B., C Y., T U.Introduction and Objective The ischemia-reperfusion injury that occurs in both the donor and the recipient during liver transplantation and the hemodynamic changes that may occur in graft afterward significantly affect the graft, sometimes triggering graft failure by causing hepatocyte damage. It is known that inhalation anesthetics provide ischemic preconditioning that prevents ischemia-reperfusion injury, but their effect on graft dysfunction caused by post-reperfusion syndrome has not yet been clarified. Our study aimed to reveal the effects of desflurane and sevoflurane used during liver transplantation on graft survival. Material and Method This retrospective study was conducted following the ethics committee approval (protocol no: 09.2021.1004/03.09.2021) and included 60 donors and recipients of liver transplantation procedures performed between 2015 and 2021. The patients were divided into two groups depending on the agent administered for anesthesia maintenance after Anesth Crit Care 2022; 4 (1): 43-51 DOI: 10.26502/acc.037 Anesthesia and Critical Care 44 standard anesthesia induction: desflurane group (Group 1, n=30) and sevoflurane group (Group 2, n=30). Recorded patient data included age, gender, body mass index, smoking status, comorbidities, presence of renal disease, total liver volume, graft volume, remaining liver volume, total ischemic time, and duration of anesthesia and surgery, graft survival, hospital stay, diastolic blood pressure measured at the beginning and the end of the procedure, systolic blood pressure; and the values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), international normalized ratio (INR), albumin, total bilirubin, blood urea nitrogen, creatinine, platelet count, and hemoglobin at the postoperative 1, 7, and 30 days. Results Demographic data and length of hospital stay of the recipients were similar (p>0.05). Intraoperative urine output of the recipient patients in the desflurane group (Group 1: 1909.52 1269.90, Group 2: 918.75618.14), ALT level at postoperative 7th day, and total bilirubin value at the 6th month were found to be significantly higher compared to the sevoflurane group (p <0.01). Discussion and Conclusion Our study revealed that preconditioning with sevoflurane during liver transplantation may have greater positive effects on early hepatic and renal functions as compared to desflurane. However, we think that it is necessary tocarry out further prospective randomized studies.Publication Open Access Cytokine Adsorption in Critically Ill COVID-19 Patients, a Case-Control Study(2022-09-01) ABDULLAYEV, RUSLAN; BİLGİLİ, BELİZ; SEVEN, SEDA; CİNEL, İSMAİL HAKKI; GÜL, FETHİ; Abdullayev R., Gül F., Bilgili B., Seven S., Cinel I.Aim: New coronavirus disease (COVID-19) has become an international emergency. As many of the intensive care unit (ICU) patients with the disease also present multiple organ failure, blood purification techniques might be a good choice in their treatment. In this study we aimed to investigate the role of cytokine removal in COVID-19 patients managed in ICUs. Methods: For this case-control study we have investigated the role of the cytokine removal by means of two resin membranes (HA330 and Mediasorb) in COVID-19 patients managed in ICUs. Particularly, we investigated the overtime variation in clinical severity scores, laboratory variables, and effects on hospital and ICU stay and mortality. Results: Seventy-two patients have been evaluated, of which half constituted Cytokine Filtration (CF) Group, and other half the Case-Control (CC) Group. Mortality was 55.6% and 50% in CF and CC groups, respectively. In the CF Group, there was decrease in C-reactive protein (CRP) and fibrinogen levels measured at the end of cytokine adsorption; lymphocyte count and ratio were increased, whereas neutrophile ratio was decreased. There were no differences between the groups regarding other laboratory variables, SOFA scores and vasopressor uses. Conclusions: We have demonstrated decrease in CRP, fibrinogen and increase in lymphocyte count in the patients having cytokine adsorption, but there was no clinical reflection of these benefits, and no decrease in mortality as well. Even though there is physio-pathologic rationale to use cytokine adsorption techniques for immunomodulation in critically ill COVID-19 patients, it is early to make strong suggestions about their benefits.Publication Metadata only COVID-19 pnömonisine bağlı sitokin salınım sendromu gelişen hastalarda tocilizumabın etkinliğinin değerlendirilmesi(2022-03-17) BİLGİLİ, BELİZ; GÜL, FETHİ; CİNEL, İSMAİL HAKKI; Değirmencioğlu G., Bilgili B., Mardin E. E., Gül F., Cinel İ. H.Publication Metadata only Yoğun bakımda COVID-19 ile ilişkili ikincil enfeksiyonlar(2022-03-17) GÜL, FETHİ; CİNEL, İSMAİL HAKKI; BİLGİLİ, BELİZ; Mardin E. E., Gül F., Bilgili B., Oktay B. D., Değirmencioğlu G., Cinel İ. H.Publication Metadata only Makrofaj aktivasyon sendromu gelişen covıd-19 hastalarında tocilizumab ve hemoadsorbsiyon tedavilerinin etkinliklerinin karşılaştırılması(2022-03-17) GÜL, FETHİ; BİLGİLİ, BELİZ; Sabaz M. S., Gül F., Korkmaz G., Oktay B. D., Kordi R. G., Bilgili B., Kaplan S. T.