Person: GÜLHAN, REZZAN
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
GÜLHAN
First Name
REZZAN
Name
21 results
Search Results
Now showing 1 - 10 of 21
Publication Open Access COLCHICINE USE DURING PREGNANCY: CASE REPORTS(BMJ PUBLISHING GROUP, 2019-06) KARAALP, ATİLA; Duman, Nesrin Caglayan; Karabacak, Murat; Oglu, Medine Gulcebi Idriz; Inanc, Nevsun; Asik, Zehra Nur Turgan; Atagunduz, Pamir; Ozkula, Songul; Gulhan, Rezzan; Goren, Zafer; Onat, Filiz; Direskeneli, Haner; Karaalp, AtilaPublication Metadata only Plasma lamotrigine levels of patients with polymorphic UGT1A4 enzymes(2010-06-27) GÜLÇEBİ İDRİZ OĞLU, MEDİNE; GÖREN, MEHMET ZAFER; GÜLHAN, REZZAN; ONAT, FİLİZ; GÜLÇEBİ İDRİZ OĞLU M., ÖZKAYNAKÇI A., GÖREN M. Z. , ÖZKARA Ç., GÜLHAN R., ONAT F.Publication Metadata only The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy(ELSEVIER, 2011) ONAT, FİLİZ; Gulcebi, Medine Idrizoglu; Ozkaynakci, Aydan; Goren, Mehmet Zafer; Aker, Rezzan Gulhan; Ozkara, Cigdem; Onat, Filiz YilmazLamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects. High performance liquid chromatography (HPLC) was used to measure serum concentrations of LTG. The P24T and L48V polymorphisms of the UGT1A4 enzyme were analyzed with a matrix assisted laser desorption-time of flight (MALDI-TOF) mass spectrometry method. The frequencies of the heterozygous alleles for L48V or P24T polymorphisms were 22.4% and 3.8%, respectively. L48V polymorphism was found to decrease the serum concentration of LTG in patients on monotherapy or polytherapy. The LTG levels of non smoking monotherapy patients were 52% lower for the L48V polymorphism than for wild type alleles. Also the LTG levels were significantly lower for non smoking or smoking polymorphic alleles than for normal. The high frequency of the L48V polymorphism detected in the Turkish population indicates that LTG dose adjustments in patients with the UGT1A4 L48V polymorphic enzyme should be taken into account. (c) 2011 Elsevier B.V. All rights reserved.Publication Metadata only The neuroprotective effect of regular swimming exercise programme on the dopaminergic neurons localized in the striatum of Parkinsonian rat models(2016-09-05) BORACI, HATİCE; KİRAZLI, ÖZLEM; GÜLHAN, REZZAN; YILDIZ, SERCAN DOĞUKAN; ŞEHİRLİ, ÜMİT SÜLEYMAN; BORACI H., KİRAZLI Ö., GÜLHAN R., YILDIZ S. D., ŞEHİRLİ Ü. S.Publication Open Access Counterfeit products containing medical active ingredients İlaç etkin maddesi İçeren sahte ürünler(2013-01-01) GÜLHAN, REZZAN; Küçükibrahimoǧlu E. E., Durmaz Z. A., Berber N., Ersoy C., Ince H., Kaymakçioǧlu B., Aşirdizer M., GÜLHAN R.Objective: Counterfeit and illegal drug trafficking is a worldwide problem. The most important substances of this trade include phosphodiesterase 5 enzyme inhibitors (PD5EI) which are used for the treatment of penil erection dysfunction, and weight loss products. These products are generally manufactured at clandestine laboratories and marketed under inappropriate conditions. The aim of this study was to examine these types of products, which have been seized by the judicial authorities in Turkey and to draw attention on the subject. Material and Methods: Products, non-alcoholic beverages and pharmaceutical compounds in the form of capsule, tablet or cream containing unlabeled sibutramine, PD5EI, and also products which were sold with these compounds seized by legal authorities and sent to the Council of Forensic Medicine for analysis between July-December 2011 were examined in this study. Results: The analysis of seized products revealed that 9 (69.2%) pharmaceutical compounds contained sildenafil, 3 (23.1%) contained local anesthetics, 1 (7.7%) contained sibutramine and beverages contained thiosildenafil. All of the products were counterfeit and they did not have a licence of production from legal authorities in Turkey or other countries, or import permission on their packages. Conclusion: Especially, PD5Is or weight loss products containing sibutramine which are widely marketed all over the world are also sold by illegal ways in our country, and because of inappropriate manufacturing and transport conditions, they cause a serious threat to public health. © 2013 by Türkiye Klinikleri.Publication Metadata only p353 Evalution of antiepileptic drug use in the pregnant patients with epilepsy in a university hospital in Istanbul(2014-07-03) GÜLÇEBİ İDRİZ OĞLU, MEDİNE; GÜLHAN, REZZAN; KARAALP, ATİLA; GÖREN, MEHMET ZAFER; ONAT, FİLİZ; GÜLÇEBİ İDRİZ OĞLU M., Küçükibrahimoğlu E., JAFAROVA DEMİRKAPU M., GÜLHAN R., KARAALP A., GÖREN M. Z., ONAT F.Publication Metadata only Frequency and type of synthetic cannabinoids analyzed in the council of forensic medicine istanbul narcotic department Turkey(2011-09-25) GÜLHAN, REZZAN; GÜRDAL F., KORKUT Ş., GÖÇER Y., KÜÇÜKİBRAHİMOĞLU E. E., GÜLHAN R., AŞIRDİZER M.Objectives: In recent years, synthetic cannabinoids are frequently observed in seized materials all over the world. These new generation designer drugs, also known as “Spice” or “Legal Highs,” can easily be obtained via the internet and are in sold mixed with herbal substances. In this study, we aimed to evaluate the type and detection frequency of synthetic cannabinoids sent to be analyzed in our laboratory over a 10-month period between August 2010 and April 2011. Materials and methods: Herbal materials sent by judicial authorities to The Council of Forensic Medicine-Istanbul Narcotic Department between August 2010 and April 2011, were analyzed in the study. All materials were analyzed by physical examination, thin layer chromatography and GC-MS (Agilent 6890GC/5973MS inert, with 30m HP-5MS column). Results: A total of 1171 herbal substances were analyzed during the 10-month investigation period and 1156 of them (98.7%) contained synthetic cannabinoids. We found both JWH-018 and JWH-081 in 760 (65.7%) samples out of 1156; JWH-018 alone in 382 (33%); CP47,497 (C8) in 5 (0.4%); both CP47,497 (C8) and JWH-018 in 7 (0.6%) samples; JWH-250 alone in 2 (0.2%) samples. Samples material had different package names such as “Bonzai Aromatic Potpori” (n=755), “Bonzai” (n=313), “Heaven” (n=14), “Aromatic Incense,” (n=6), “Yukatan Fire” (n=7), “Tribal Warrior Ultimate” (n=5), “Jamaican Gold” (n=43) and “Jamaican Sprit” (n=5). All Bonzai packages (n=313) contained JWH-018 while 2 samples contained JWH-250. JWH-018 along with JWH-081 was detected in “Bonzai Aromatic Potpori” (n=755) and in “Jamaican Spirit” (n=5). All “Yukatan Fire” packages contained JWH-018 with CP47,497 (C8). “Tribal Warrior Ultimate” packages had CP47,497(C8) (n=5). The rest of packages with different names had JWH-018. Conclusions: JWH-018 was the most frequent type of synthetic cannabinoids (detected in 98.7% of 1156 samples). “Bonzai” and “Bonzai Aromatic Potpori” were the most common product name amongst the herbal products sent to our laboratory (n=1068). Although some of these synthetic cannabinoid compounds are banned by law, there is not an “analogue or derivative” clause established in Turkey yet. The increase use of different derivatives, lack of analytical data and reference standards for analysis, lack of information on metabolism and metabolites for toxicological analysis in human subjects are important problems that need to be solved.Publication Metadata only Review of detection frequency and type of synthetic cannabinoids in herbal compounds analyzed by Istanbul Narcotic Department of the Council of Forensic Medicine, Turkey(ELSEVIER SCI LTD, 2013) GÜLHAN, REZZAN; Gurdal, Fatma; Asirdizer, Mahmut; Aker, Rezzan Gulhan; Korkut, Senol; Gocer, Yasemin; Kucukibrahimoglu, E. Esra; Ince, C. HalukIn recent years, synthetic cannabinoids have been frequently observed in seized materials all over the world. This new generation of designer drugs, mixed with herbal substances, is also known as Herbal Highs or Legal Highs. There are many articles about the history, type and pharmaco-chemical properties of synthetic cannabinoids in the literature; however the number of articles about the frequency of their detection is limited. In this study, we evaluated the type and detection frequency of synthetic cannabinoids in Istanbul and its surrounding area. The reports of the Council of Forensic Medicine-Istanbul Narcotic Department were retrospectively reviewed for the presence of synthetic cannabinoids in herbal compounds sent by the judicial authorities between August 01, 2010 and March 31, 2012. Among 1200 herbal compounds, 1179 of them (98.3%) contained synthetic cannabinoids. Twenty-one samples (1.7%) had other psychoactive substances. The analysis of 1179 samples showed that JWH-018 was present in 1172 (99.4%) of the samples. JWH-081 was found in 777 samples (65.9%) together with JWH-018. Samples had different package names. Bonzai Aromatic Potpourri (n = 755; 64.0%) and Bonzai Plant Growth Regulator (n = 316; 26.8%) were the most common product names amongst the herbal products in this study. It is clear from the present study and previous studies that brand name of synthetic cannabinoids that dominate the market exhibit regional differences as to the type and detection frequency of synthetic cannabinoids and the content of herbal highs packages. The number and diversity of synthetic cannabinoid compounds have increased dramatically in the drug market in recent years. New, different, potent derivatives appear on the market, almost every clay and this presents important problems that need to be solved by scientists and judicial authorities working to prevent their harm. These problems include the limited knowledge about their frequency, the lack of analytical data and reference standards for analysis of these new derivates, the lack of information on their toxic effects, and information about the metabolism and metabolites for toxicological analysis in human subjects. (c) 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.Publication Metadata only A review of suspected cases of driving under the influence of drugs (DUID) involved in traffic accidents in Istanbul (Turkey)(ELSEVIER SCI LTD, 2013) GÜLHAN, REZZAN; Acar, Fatih; Asirdizer, Mahmut; Aker, Rezzan Gulhan; Kucukibrahimbglu, E. Esra; Ates, Ismail; Erol, Yeter; Sahin, AysegulNowadays traffic accidents, which have high mortality and morbidity, are an important public health problem. The association between the use of alcohol and/or drugs by drivers and the increased risk of traffic accidents with a high risk of death and injury has been well described in the literature. This study aimed to review the incidence of cases of driving under the influence of drugs (DUID) among all cases of driving under the influence (DUI) of alcohol and/or other drugs involved in traffic accidents and to evaluate the type of the psychoactive drugs (with or without alcohol) detected in blood samples in Istanbul and its surrounding area. This study is the first investigation on the subject of DUID cases in Turkey. The reports of the Istanbul Toxicology Department of the Council of Forensic Medicine (Turkey) on suspected DUID cases involved in traffic accidents between 1 July 2010 and 30 June 2011 were retrospectively reviewed for alcohol and/or drug use. Alcohol analysis was requested in 4274 suspected DUI cases, whereas drug along with alcohol analysis was requested in only 91. The rate of suspected DUID cases (n = 91) among the suspected DUI cases (n = 4274) was only 2.1% and in this study, we evaluated only the DUID cases in detail. Alcohol was present in 44% of suspected DUID cases. Psychoactive drugs were present in 15.4% of cases. The incidence among 46 confirmed DUID cases was found to be 17.4% for cannabis, 8.7% for benzodiazepines, 4.3% for barbiturates, 4.3% for antidepressants, 2.2% for cocaine and 2.2% for amphetamines. Although there is a zero-tolerance approach for DUID in the Turkish regulations, it is not well recognised and not inspected by police and legal authorities who are responsible for taking measures in traffic accidents and for routine traffic controls in Turkey. It is concluded that psychoactive drugs should be checked as well as alcohol in all traffic accident cases and roadside controls. (c) 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.Publication Metadata only Changes in intracellular protein expression in cortex., thalamus and hippocampus in a genetic rat model of absence epilepsy(PERGAMON-ELSEVIER SCIENCE LTD, 2011) OGAN, AYŞE; Danis, Ozkan; Demir, Serap; Gunel, Aslihan; Aker, Rezzan Gulhan; Gulcebi, Medine; Onat, Filiz; Ogan, AyseEpilepsy is a chronic disorder characterized by repeated seizures resulting from abnormal activation of neurons in the brain. Although mutations in genes related to Na+, K+, Ca2+ channels have been defined, few studies show intracellular protein changes. We have used proteomics to investigate the expression of soluble proteins in a genetic rat model of absence epilepsy Genetic Absence Epilepsy Rats from Strasbourg (GAERS). The advantage of this technique is its high throughput quantitative and qualitative detection of all proteins with their post-translational modifications at a given time. The parietal cortex and thalamus, which are the regions responsible for the generation of absence seizures, and the hippocampus, which is not involved in this activity, were dissected from GAERS and from non-epileptic control rat brains. Proteins from each tissue sample were isolated and separated by two-dimensional gel electrophoresis. Spots that showed significantly different levels of expression between controls and GAERS were identified by nano LC-ESI-MS/MS. Identified proteins were: ATP synthase subunit delta and the 14-3-3 zeta isoform in parietal cortex; myelin basic protein and macrophage migration inhibitory factor in thalamus; and macrophage migration inhibitory factor and 0-beta 2 globulin in hippocampus. All protein expressions were up-regulated in GAERS except 0-beta globulin. These soluble proteins are related to energy generation, signal transduction, inflammatory processes and membrane conductance. These results indicate that not only membrane proteins but also cytoplasmic proteins may take place in the pathophysiology and can be therapeutic targets in absence epilepsy. (C) 2011 Elsevier Inc. All rights reserved.
- «
- 1 (current)
- 2
- 3
- »