Person: HASDEMİR GÖKBOĞA, MÜNEVVER UFUK
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HASDEMİR GÖKBOĞA
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MÜNEVVER UFUK
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Publication Open Access Catalase-negative Staphylococcus aureus: a rare isolate of human infection(BLACKWELL SCIENCE LTD, 2000-12) HASDEMİR GÖKBOĞA, MÜNEVVER UFUK; Over, U; Tuc, Y; Soyletir, GPublication Metadata only Simple and reliable detection of slime production of Candida spp. directly from blood culture bottles: Comparison of visual tube method and transmission electron microscopy(SPRINGER, 2004) HASDEMİR GÖKBOĞA, MÜNEVVER UFUK; Cerikcioglu, N; Hasdemir, UO; San, T; Salik, E; Soyletir, GEarly detection of slime production may be useful for clinical decision because of its suggestive property for potential pathogenic capacity of a Candida strain especially in patients with a prosthetic device. In this study we aimed to compare the visual tube method (VTM) with transmission electron microscopy (TEM) in order to confirm the reliability of the former method. In order to demonstrate the reproducibility of the tube method and to determine the correct timing for the test, Candida isolates directly obtained from blood culture (DBC) bottles and their two subsequent subcultures were used. The results of this study showed that VTM is a simple and reliable method which can be used in every clinical mycology laboratory, provided that the test is applied on DBC isolates; as the ability of slime production is decreased or lost even after the first subculturing. We suggest that this simple method can be used and may have some contributions to the ongoing studies on the controversial issue concerning removal of biomaterials in candidemic patients.Publication Open Access The changing nature of aminoglycoside resistance mechanisms and prevalence of newly recognized resistance mechanisms in Turkey(BLACKWELL SCIENCE LTD, 2001-09) HASDEMİR GÖKBOĞA, MÜNEVVER UFUK; Over, U; Gur, D; Unal, S; Miller, GHObjective, To determine the most frequently. occurring individual and combined resistance mechanisms, in Gram-negative bacteria resistant to any of the clinically available aminoglycosides in Turkey, and to compare these mechanisms with those found in smaller, earlier studies. Methods Aminoglycoside resistance mechanisms in Gram-negative isolates, resistant to either gentamicin, tobramycin, netilmicin or amikacin collected in different regions of Turkey were evaluated both phenotypically and genotypically using 12 aminoglycosides, and up to 22 aminoglycoside resistance gene probes. Results Among 696 aminoglycoside-resistant Gram-negative bacteria, resistance rates were very high for gentamicin (94.5%), tobramycin (82.4%). netilmicin (53.6%), and amikacin (49.7%). Although isepamicin was the most active aminoglycoside, against Gram-negative bacteria, increased resistance (29.7%) was found and resistance rates were higher than those in most of the other countries surveyed in earlier studies. The most common aminoglycoside resistance mechanisms (AAC(3)-II (GTN), AAC(6)-I (TNA), and ANT(2)-I (GT)) in the earlier studies were also found in the present isolates of Klebsiella spp., Enterobacter spp. and Escherichia coli, with increased complexity. In addition to these old mechanisms, two new aminoglycoside resistance mechanisms, namely AAC(6)-III (TNAI) and AAC(6)-IV (GTNA), were also found at significant frequencies (11.9% and 26.9%, respectively) in these isolates of Enterobacteriaceae (n = 435). Among the isolates of Pseudomonas spp. (n = 150), in addition to the increased complexity of enzymatic resistance mechanisms (AAC(3)-I (16.6%), AAC(6')-II (29.3%), AAC(6)-III (19.3%), ANT(2)-I (40%)), permeability resistance seemed to be responsible for the high rates of resistance to, aminoglycosides. Conclusion The results of this. study indicated increased resistance to clinically available aminoglycosides, including isepamicin, even though it was, the most active, as a result of both the presence of new aminoglycoside resistance mechanisms and the increased, complexity of all mechanisms, including permeability resistance, particularly in Pseudomonas in Turkey.Publication Metadata only High prevalence of amebiasis in ulcerative colitis patients compared to Crohn’s disease;ten year follow-up results from a university hospital, Turkey(2006-03-24) DUMAN, DENİZ; İLKİ, ZEYNEP ARZU; HASDEMİR GÖKBOĞA, MÜNEVVER UFUK; Duman D., İlki Z. A., Hasdemir Gökboğa M. U., İmeryüz N., Tüzün N., Hamzaoğlu H.Publication Metadata only Comparative antimicrobial susceptibilities of ttreptococcus pneumoniae, and haemophilus influenzae in a university hospital in Turkey(2006-04-03) İLKİ, ZEYNEP ARZU; HASDEMİR GÖKBOĞA, MÜNEVVER UFUK; SÖYLEDİR, GÜNER; İlki Z. A., Sağıroğlu P., Elgörmüş N., Hasdemir Gökboğa M. U., Söyledir G.