Person: TEZCAN, SONGÜL
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TEZCAN
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SONGÜL
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Publication Metadata only Aprepitant in the Treatment of Subacute Sclerosing Panencephalitis: A Randomized, Double-Blind, Placebo-Controlled Study(ELSEVIER SCIENCE INC, 2020) ARMAN KANDIRMAZ, EMİNE; Oncel, Ibrahim; Sancar, Mesut; Konuskan, Bahadir; Arioz, Filiz; Tezcan, Songul; Arman-Kandirmaz, Emine; Parlak, Safak; Gumeler, Ekim; Anlar, BanuBackground: Aprepitant is a neurokinin-1 receptor antagonist approved for the treatment of chemotherapy-induced nausea. We aimed to investigate the safety and efficacy of aprepitant in patients with subacute sclerosing panencephalitis. Methods: A randomized, double-blind, placebo-controlled study was conducted in patients with subacute sclerosing panencephalitis assigned to receive two courses of aprepitant 250 mg/day orally or placebo for 15 days with an interval of two months between courses. Primary end points were safety and tolerability, and secondary end point was clinical improvement or stabilization assessed by subacute sclerosing panencephalitis scoring system. Electroencephalography (EEG), brain magnetic resonance imaging, and cerebrospinal fluid measles-specific immunoglobulin G index were evaluated before and after treatment. Results: Sixty-two patients with subacute sclerosing panencephalitis were allocated to aprepitant (n = 31, median age 18 years) or placebo (n = 31, median age 22 years) group. Fifteen patients left the study within the first six months and 12 patients left between six and 12 months. Aprepitant was well tolerated and treatment-associated adverse events were similar to those described in the treatment of nausea. Clinical status at six and 12 months' follow-up did not differ between aprepitant and placebo groups. Post-treatment EEG scores at 12 months were better in the aprepitant group (P = 0.015). Cerebral atrophy on magnetic resonance imaging increased in both groups, whereas measles-specific immunoglobulin G index decreased in the placebo group. Conclusions: In this first clinical trial of aprepitant treatment in patients with subacute sclerosing pan encephalitis, the drug was safe and well tolerated. No clinical effect was observed. A modest improvement in EEG findings might justify trials for longer periods because EEG changes can precede clinical findings in subacute sclerosing panencephalitis. (C) 2020 Elsevier Inc. All rights reserved.Publication Metadata only Knowledge, awareness, and attitudes of pharmacists about dermocosmetic products - adescriptive study(2023-11-02) TEZCAN, SONGÜL; BİLİCİ B., TEZCAN S., İLERİ Y., FARBOUİDİ A.Publication Metadata only The effect of pharmaceutical care practices on clinical competencies and professional preparednessof students(2023-06-04) TEZCAN, SONGÜL; YÜRÜK F. U., AY Z. Y., UÇAR YAMAN N., TEZCAN S., YÜKSEL H. G., MERCANOĞLU H. G.Publication Metadata only Factors affecting the career preference of pharmacystudents(2023-08-11) TEZCAN, SONGÜL; AY Z. Y., TEZCAN S., Akar M. C., KALE E.Diabetes is a global health concern. Pharmacists contribute to improving health outcomes by providing pharmaceutical care to patients with Diabetes Mellitus (DM). There are studies showing that pharmacy students need more knowledge in order to competently contribute to diabetes management. The aim of this study is to determine the level of diabetes knowledge of the undergraduate students of Health Sciences University Hamidiye Faculty of Pharmacy. A cross sectional study using online self-administered survey was conducted during 2 weeks among the 4th and 5th year pharmacy students. Sociodemographic characteristics of the students were collected. A structured questionnaire about the definition, causes and symptoms of diabetes (40 items) [1] were applied. The response options were “yes; no; or I do not know”. Each correct answer was scored as 1 point, incorrect or I don't know answers are scores as 0 point. The maximum possible score was 40. Diabetes Knowledge Scale scores and the correlation of the scores with students’ sociodemographic characteristics are main outcome measures. Of the 196 students 77% were female and 43.4% of them had diabetes family history. Forty-one percent of the participants stated that they were involved in the care of at least one diabetes patient. The mean knowledge score was found to be as 34.07 ± 4.13. The subscale scores were found to be as follows; diabetes general knowledge 7.04 ± 1.15 (8 items), diabetes risk factor 2.88 ± 0.37 (3 items), diabetes symptoms 2.70 ± 0.53 (3 items), diabetes diagnosis 3.46 ± 0.91 (4 items), diabetes treatment 7.64 ± 1.62 (10 items), diabetes complications 3.81 ± 0.58 (4 items), and diabetes diet and exercise 3.78 ± 1.19 (5 items), and diabetes control 2.76 ± 0.48 (3 items). The Cronbach's alpha value of the scale was found to be 0.767. Students were found to have adequate background knowledge regarding diabetes diagnosis, symptoms, and risk factors. However, knowledge deficits in areas such as diet in diabetes and treatment in gestational diabetes have been identified among participants.Publication Metadata only Therapeutic drug monitoring of aprepitant with liquid chromatography–massspectrometry(2023-10-31) TEZCAN, SONGÜL; ARMAN KANDIRMAZ, EMİNE; SANCAR, MESUT; TEZCAN S., Kunal G., ÖZDEMİR F., ARMAN KANDIRMAZ E., SANCAR M.Publication Metadata only Evaluation of diabetes knowledge of pharmacy students(2023-08-11) TEZCAN, SONGÜL; RABUŞ, ŞULE; AY Z. Y., TEZCAN S., APİKOĞLU Ş.Diabetes is a global health concern. Pharmacists contribute to improving health outcomes by providing pharmaceutical care to patients with Diabetes Mellitus (DM). There are studies showing that pharmacy students need more knowledge in order to competently contribute to diabetes management. The aim of this study is to determine the level of diabetes knowledge of the undergraduate students of Health Sciences University Hamidiye Faculty of Pharmacy. A cross sectional study using online self-administered survey was conducted during 2 weeks among the 4th and 5th year pharmacy students. Sociodemographic characteristics of the students were collected. A structured questionnaire about the definition, causes and symptoms of diabetes (40 items) [1] were applied. The response options were “yes; no; or I do not know”. Each correct answer was scored as 1 point, incorrect or I don't know answers are scores as 0 point. The maximum possible score was 40. Diabetes Knowledge Scale scores and the correlation of the scores with students’ sociodemographic characteristics are main outcome measures. Of the 196 students 77% were female and 43.4% of them had diabetes family history. Forty-one percent of the participants stated that they were involved in the care of at least one diabetes patient. The mean knowledge score was found to be as 34.07 ± 4.13. The subscale scores were found to be as follows; diabetes general knowledge 7.04 ± 1.15 (8 items), diabetes risk factor 2.88 ± 0.37 (3 items), diabetes symptoms 2.70 ± 0.53 (3 items), diabetes diagnosis 3.46 ± 0.91 (4 items), diabetes treatment 7.64 ± 1.62 (10 items), diabetes complications 3.81 ± 0.58 (4 items), and diabetes diet and exercise 3.78 ± 1.19 (5 items), and diabetes control 2.76 ± 0.48 (3 items). The Cronbach's alpha value of the scale was found to be 0.767. Students were found to have adequate background knowledge regarding diabetes diagnosis, symptoms, and risk factors. However, knowledge deficits in areas such as diet in diabetes and treatment in gestational diabetes have been identified among participants.Publication Metadata only Community Pharmacists' Knowledge on Cancer and Screening Methods(SAGE PUBLICATIONS LTD, 2022) TEZCAN, SONGÜL; Uygun, Aysen; Caliskan, Nazli Dilek; Tezcan, SongulBackground and Objective The aim of the study is to evaluate the knowledge of community pharmacists on cancer and screening methods. Setting and Method This study was a descriptive cross-sectional study and was conducted between January-June 2020 in Istanbul/Turkey. a structured questionnaire was applied to pharmacists as online. The questionnaire was prepared by the researchers and consisted of 49 questions; basic information about cancer (15 items), signs and symptoms (11 items), causes and risk factors (14 items), cancer screening methods (9 items). Results It was determined that the majority (>90%) of the pharmacists did not receive any education on cancer and/or cancer screening methods after graduation. The sufficient knowledge level of the pharmacists about cancer basics, signs and symptoms, and risk factors were found to be as 80%, 77%, and 67%, respectively. The internal consistency level of the questionnaire was calculated (Cronbach's alpha = 0.814). The item Every woman should perform breast self-examination and notify a health professional when there is a change in breast appearance or feeling, was answered correctly by 98% of the pharmacists. It was determined that 71% of the pharmacists gave the correct answer to the item Women aged 21-30 years should have a PAP smear every 3 years. Conclusion According to the results of the study, while the rate of sufficient knowledge level on cancer was found to be low, knowledge on cancer screening was found to be sufficient. We think that pharmacists should receive training on cancer and screening methods and to follow the guidelines closely.Publication Metadata only Determination of treatment satisfactıon and medication adherence of patients receıvıng antithrombotic therapy in a community setting(2022-12-02) TEZCAN, SONGÜL; Düzenli E., TEZCAN S., YÜRÜK F. U.Aim: Antithrombotic drugs are high-risk drugs and their side effects are the most important problems that negatively affect compliance with medication and treatment. The aim of our study is to evaluate medication compliance and treatment satisfaction in patients receiving anticoagulant and antithrombotic therapy in a community pharmacy. Methods: This study was cross-sectional, prospective, and consisted of patients receiving antithrombotic and anticoagulant therapy. It was conducted in a community pharmacy in Istanbul. The Medication Adherence Report Scale (MARS) and the Duke anticoagulant satisfaction scale (DASS) were administered face-to-face to the patients. SPSS 15.0 statistical program was used for the analysis. Results: The median age of the patients was 79 and 62% of them were female patients. The median duration of anticoagulant use of the patients was 3 years, and 40% of them were using clopidogrel. The patients' median MARS score was found to be 22 and the median DASS total score was 39. DASS total score and its subdimensions were found to be significantly positively correlated (p<0.001). Patients with low educational levels and patients using warfarin were found to have a higher DUKE total score (p<0.05). Conclusions: According to the results of our study, although the patients' medication adherence scores and treatment satisfaction were high, it was found to be lower in patients with low education and warfarin use. Therefore, considering these results, it may be important to provide drug information counseling services to patients receiving anticoagulant and antithrombotic treatment.Publication Metadata only Assessment of chemotherapy-related educational needs of colorectal cancer patients(2022-08-01) TEZCAN, SONGÜL; RABUŞ, ŞULE; TEZCAN S., Tanir G. I., Yilmaz H., Memis S., Yumuk P. F., APİKOĞLU Ş.Aim Aim of our study was to evaluate cancer patients\" knowledge about their chemotherapy regimens in order to assess educational needs of patients. Methods Study was conducted on 58 colorectal carcinoma patients who were treated in an outpatient chemotherapy unit. These patients had received a 2-page information pamphlet about their chemotherapy treatments before the commencement of treatment. During the first interview with patients, pharmacist collected demographic data and evaluated patients\" knowledge about their medications using a standardized questionnaire. Findings Mean age of the patients was 59.6 +/- 1.3 years; 65.5% were male. Majority (77.6%) of patients were graduates of primary school. Sixty-four percent of these had at least one comorbid disease. Median number of chemotherapy courses already received by patients was 4 (1-9). Fifty-nine percent reported that they did not receive any patient education and 43.1% reported that they did not receive any informative document. Twenty-nine percent of patients did not know what actions to take in case of nausea-vomiting; while 53.4% did not know how to react if their body temperature exceeded 38 degrees C and 25.9% had no idea about dietary necessities. About one-third of patients did not pay attention to oral care. Conclusion Our study showed that patients did not understand (or remember) the basic points about their chemotherapy sufficiently, but remembered the adverse effects they experienced occasionally. Pharmacists will have the chance to increase the level of knowledge of the patients receiving chemotherapy by providing patient education and follow-up.Publication Metadata only Applications of mass spectrometry in oncology: diagnosis to treatment(2023-05-15) TEZCAN, SONGÜL; TEZCAN S., ÖZDEMİR F.
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