Person: KURU, LEYLA
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KURU
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LEYLA
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Publication Metadata only Evaluation of gingival crevicular fluid transforming growth factor-1 level after treatment of intrabony periodontal defects with enamel matrix derivatives and autogenous bone graft: A randomized controlled clinical trial(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016) YARAT, AYŞEN; Agrali, O. B.; Kuru, B. E.; Yarat, A.; Kuru, L.Aim: The present study aimed to evaluate the effects of enamel matrix derivatives (EMD) either alone or combined with autogenous bone graft (ABG) applied to intrabony defects in chronic periodontitis patients on clinical/radiographic parameters and gingival crevicular fluid (GCF) transforming growth factor-1 (TGF-1) level and to compare with open flap debridement (OFD). Materials and Methods: A total of 30 deep intrabony defects in 12 patients were randomly treated with EMD + ABG (combination group), EMD alone (EMD group), or OFD (control group). Clinical parameters, including plaque index, gingival index, bleeding on probing, probing depth, relative attachment level, and recession were recorded at baseline and 6 months postsurgery. Intrabony defect fill percentage was calculated on the standardized radiographs. TGF-1 level was evaluated in GCF just before surgery and 7, 14, 30, 90, 180 days after surgery using enzyme-linked immunosorbent assay. Results: All treatment procedures led to significant improvements at 6 months (P 0.01). Gain in attachment level (P 0.01) and radiographic defect fill (P 0.05) of the combination and EMD groups were found to be significantly higher than those of the control group, while the use of EMD either with ABG or alone was observed to produce significantly less recession than the OFD (P 0.05). Conclusion: The findings suggest no clinical and radiographic differences between the combination and EMD groups whereas GCF TGF-1 level demonstrates an increase during the healing phase and is positively affected from EMD.Publication Metadata only Do Platform Switching Together with Subcrestal Placement have a Benefit on Marginal Bone Levels Around Dental Implants?(AVES PRESS LTD, 2018) KURU, LEYLA; Agrali, Omer Birkan; Elemek, Eser; Dincer, Janberd; Kigili, Ahmet; Cilingir, Altug; Kuru, Leyla; Almas, KhalidObjective: The aim of this retrospective study was to assess the marginal bone levels around platform-switched dental implants placed subcrestally in partially or totally edentulous patients who had been treated in a private practice. Methods: A total of 200 implants placed in 64 patients, with a mean follow-up time of 5.3 +/- 1.7 years, were included in the study. Implants were placed 0.5 mm subcrestally via one-or two-stage surgical approach. Data regarding the distribution and diameter of the implants, the type of the prosthetic restoration, and marginal bone levels were assessed by one calibrated examiner. Results: Overall, the mean marginal bone loss was found to be 0.82 +/- 1.6 mm, and 66% of the implants (n=81) showed no bone loss, whereas 28% (n=35) showed bone loss >1mm, and 20% (n=25) showed bone loss >2mm. Out of 18 implants in use for 1-3 years, 14 of them showed no bone loss. Among implants that were in function for 3-5 years, 25% (n=15) showed bone loss >1mm, and 12% (n=7) showed bone loss >2mm. In this study, the majority of the implants were in use for more than 5 years (n=122). Out of them, 66% (n=81) showed no bone loss, whereas 28% (n=35) showed bone loss >1 mm, and 20% (n=25) showed bone loss >2mm. Conclusion: Within the limits of this retrospective study, one can say that slight amount of marginal bone loss is observed around the platform-switched implants placed subcrestally in a long-term follow-up. However, further studies are needed to confirm this finding.Publication Metadata only Peri-implant Tissues and Diseases(MARMARA UNIV, INST HEALTH SCIENCES, 2017) YILDIRIM, HATİCE SELİN; Elemek, Eser; Agrali, Omer Birkan; Yildirim, Hatice Selin; Kuru, LeylaPeri-implant diseases occur due to imbalance between host response and biofilm after successful osseointegration of an implant with the bone. Among peri-implant diseases, peri-implant mucositis is used to describe the presence of inflammation only within the mucosa, whereas peri-implantitis is characterized by loss of supporting bone in addition to the inflammation within the mucosa. For the diagnosis of peri-implant diseases, probing depth, bleeding on probing, and suppuration are clinically assessed. Additionally, supporting bone levels are radiographically evaluated. Smoking, lack of oral hygiene, history of periodontal disease, diabetes mellitus, cardiovascular diseases, and implant surface characteristics are the known risk factors for the development of peri-implant diseases. For the treatment of peri-implant mucositis, antimicrobial treatment is performed together with mechanical debridement. However, these treatment approaches are not sufficient for peri-implantitis cases. For the treatment of peri-implantitis, resective and/or regenerative surgical interventions are used in addition to mechanical debridement. It is crucial to improve the knowledge among dentists about the prevention and progression of peri-implant diseases. On the other hand, patients should be advised regular dental visits and to maintain the highest level of oral hygiene.Publication Metadata only The gingival crevicular fluid levels of growth factors in patients with amlodipine-induced gingival overgrowth: A pilot study(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2020) YILDIRIM, HATİCE SELİN; Kose, K. N.; Yilmaz, S.; Noyan, U.; Kuru, B.; Yildirim, H. S.; Agrali, O. B.; Ozener, H. O.; Kuru, L.Background: Amlodipine, calcium channel blocker (CCB), is used in the management of cardiovascular diseases which causes gingival overgrowth (GO). The growth factors may have a role in the pathogenesis of amlodipine-induced GO. Objectives: This pilot study aimed to investigate the growth factors including transforming growth factor-b1 (TGF-b1), platelet-derived growth factor-BB (PDGF-BB), and basic fibroblast growth factor (bFGF) in gingival crevicular fluid (GCF) of patients with amlodipine-induced GO and compare with of healthy subjects. Methods: GCF samples were collected from 56 sites presenting GO (GO + group) and from 38 sites not presenting GO (GO- group) of 5 patients using amlodipine for more than one year, and from 45 sites (control group) of 5 healthy subjects. The levels of TGF-b1, PDGF-BB, and bFGF were determined by using ELISA kits. Results: The mean concentration of TGF-b1 in GCF samples of GO + group (9.50 +/- 7.30 ng/ml) was higher than both GO- group (2.07 +/- 0.50 ng/ml) and control group (2.74 +/- 1.01 ng/ml) (P = 0.014). No significant difference was found among the groups in the GCF levels of PDGF-BB (P = 0.767). bFGF was detected in only 33% of the sites from patients. Conclusion: These preliminary results suggest that TGF-b1 may play a crucial role in the pathogenesis of amlodipine-induced GO.Publication Metadata only Extra- and Intraoral Clinical Findings of Recessive Dystrophic Epidermolysis Bullosa: A Case Report(AVES PRESS LTD, 2016) NAMDAR PEKİNER, FİLİZ MEDİHA; Meseli, Suleyman Emre; Agrali, Omer Birkan; Pekiner, Filiz Namdar; Kuru, LeylaEpidermolysis bullosa (EB) is a heterogeneous group of inherited blistering mucocutaneous disorders that have a specific defect in the attachment mechanisms of the epithelial cells, either to each other or to the underlying connective tissue. Recessive dystrophic type EB (Hallopeau-Siemens syndrome) represents repeated episodes of cutaneous breakdown, which heal with scarring, resulting in the fusion of the fingers into a mitten-like deformity. The vesicle/bulla can be intraorally observed and the depth of the buccal vestibule may decrease because of scarring. In this case report, the intra-/extraoral findings of a 25-year-old male patient, who was diagnosed with recessive dystrophic type EB immediately after birth, are presented. Extraoral examination revealed mitten-like hands and feet because of scar tissue formations on the hands and feet. Similarly, during intraoral examination, scar tissue formations were observed that had caused denuded mouth opening and limited tongue functions. In addition, periodontal problems and dental caries were observed because of limited plaque control. This case report emphasizes the importance of knowledge regarding patients with EB and presents some intraoral findings.Publication Metadata only Rat kalvaryal defektlerinde D3 vitamininin yönlendirilmiş kemik rejenerasyonu üzerine etkisinin değerlendirilmesi(2022-11-06) AĞRALI, ÖMER BİRKAN; YILDIRIM, HATİCE SELİN; KURU, LEYLA; ÖZTÜRK ÖZENER, HAFİZE; HANCILAR G. N., AĞRALI Ö. B., GÜNGÖRMEK H. S., DEMİRCİ DELİPINAR S., KURU L., ÖZTÜRK ÖZENER H.Amaç: Bu çalışmada oral yolla verilen D3 vitamininin ratlarda yönlendirilmiş kemik rejenerasyonuna etkisinin histolojik olarak değerlendirilmesi amaçlandı. Gereç-Yöntem: Çalışma 12 adet erişkin erkek SpragueDawley cinsi rat üzerinde gerçekleştirildi. Tüm ratların kalvaryal kemiklerinde 5 mm çapında oluşturulan defektlere sığır kaynaklı kemik grefti (BioOss®) ile birlikte kolajen esaslı rezorbe olabilen membran (BioGide®) uygulandı. Cerrahi sonrası ratlar rastgele iki gruba ayrıldı; birinci gruba (Kontrol Grubu) distile su, ikinci gruba (Test Grubu) ise 2 µg /kg D3 vitamini günde 1 kez olmak üzere gavajla 8 hafta boyunca verildi. 8 haftanın sonunda ratlar sakrifiye edildi. Hematoksilen-Eozin ile boyanan örnekler histolojik olarak incelendi. ImageJ yazılım programı kullanılarak yeni kemik, rezidüel greft ve fibröz doku alanları hesaplandı. Verilerin istatistiksel analizleri GraphPad Prism programında değerlendirildi. İstatistiksel anlamlılık p<0,05 olarak kabul edildi. Bulgular: Yeni kemik alan yüzdesinin test grubunda (%43,75) kontrol grubundan (%28,35) istatistiksel olarak anlamlı yüksek olduğu tespit edildi (p<0,05). Rezidüel greft alanı, test grubunda 0,56 ±0,21 mm2 iken kontrol grubunda 0,89±0,17 mm2 olarak saptandı (p<0,05). Fibröz doku alanının, test grubu (1,00±0,27 mm2) ile kontrol grubunda (1,10±0,23 mm2) benzer olduğu gözlendi (p>0,05). Sonuç: Bu çalışmanın sonuçları, yönlendirilmiş kemik rejenerasyonunu takiben oral yolla kullanılan D3 vitamininin ratların kritik boyuttaki kalvaryal defektlerinde yeni kemik dokusu oluşumunu artırdığını göstermiştir.